Study quiescence heterogeneity by coupling single-cell measurements and computer modeling

Jungeun Sarah Kwon, Xia Wang, Guang Yao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Single-cell measurements combined with mathematical modeling and computer simulations are powerful tools for understanding and exploring dynamical behaviors of gene networks and cellular functions that they control. Here, we describe experimental and computational methods to study cellular quiescence and its heterogeneity at the single-cell level.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages287-299
Number of pages13
Volume1686
DOIs
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
Volume1686
ISSN (Print)1064-3745

Keywords

  • Cell cycle
  • Click-iT EdU assay
  • Deterministic simulation
  • DNA content
  • Fluorescent protein reporter
  • Heterogeneity
  • Ordinary differential equation (ODE)
  • Quiescence
  • Stochastic simulation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Kwon, J. S., Wang, X., & Yao, G. (2018). Study quiescence heterogeneity by coupling single-cell measurements and computer modeling. In Methods in Molecular Biology (Vol. 1686, pp. 287-299). (Methods in Molecular Biology; Vol. 1686). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-7371-2_20