Study quiescence heterogeneity by coupling single-cell measurements and computer modeling

Jungeun Sarah Kwon, Xia Wang, Guang Yao

Research output: ResearchChapter

Abstract

Single-cell measurements combined with mathematical modeling and computer simulations are powerful tools for understanding and exploring dynamical behaviors of gene networks and cellular functions that they control. Here, we describe experimental and computational methods to study cellular quiescence and its heterogeneity at the single-cell level.

LanguageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages287-299
Number of pages13
Volume1686
DOIs
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
Volume1686
ISSN (Print)1064-3745

Fingerprint

Gene Regulatory Networks
Computer Simulation

Keywords

  • Cell cycle
  • Click-iT EdU assay
  • Deterministic simulation
  • DNA content
  • Fluorescent protein reporter
  • Heterogeneity
  • Ordinary differential equation (ODE)
  • Quiescence
  • Stochastic simulation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Kwon, J. S., Wang, X., & Yao, G. (2018). Study quiescence heterogeneity by coupling single-cell measurements and computer modeling. In Methods in Molecular Biology (Vol. 1686, pp. 287-299). (Methods in Molecular Biology; Vol. 1686). Humana Press Inc.. DOI: 10.1007/978-1-4939-7371-2_20

Study quiescence heterogeneity by coupling single-cell measurements and computer modeling. / Kwon, Jungeun Sarah; Wang, Xia; Yao, Guang.

Methods in Molecular Biology. Vol. 1686 Humana Press Inc., 2018. p. 287-299 (Methods in Molecular Biology; Vol. 1686).

Research output: ResearchChapter

Kwon, JS, Wang, X & Yao, G 2018, Study quiescence heterogeneity by coupling single-cell measurements and computer modeling. in Methods in Molecular Biology. vol. 1686, Methods in Molecular Biology, vol. 1686, Humana Press Inc., pp. 287-299. DOI: 10.1007/978-1-4939-7371-2_20
Kwon JS, Wang X, Yao G. Study quiescence heterogeneity by coupling single-cell measurements and computer modeling. In Methods in Molecular Biology. Vol. 1686. Humana Press Inc.2018. p. 287-299. (Methods in Molecular Biology). Available from, DOI: 10.1007/978-1-4939-7371-2_20
Kwon, Jungeun Sarah ; Wang, Xia ; Yao, Guang. / Study quiescence heterogeneity by coupling single-cell measurements and computer modeling. Methods in Molecular Biology. Vol. 1686 Humana Press Inc., 2018. pp. 287-299 (Methods in Molecular Biology).
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