Subcellular trafficking of the papillomavirus genome during initial infection: The remarkable abilities of minor capsid protein l2

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Since 2012, our understanding of human papillomavirus (HPV) subcellular trafficking has undergone a drastic paradigm shift. Work from multiple laboratories has revealed that HPV has evolved a unique means to deliver its viral genome (vDNA) to the cell nucleus, relying on myriad host cell proteins and processes. The major breakthrough finding from these recent endeavors has been the realization of L2-dependent utilization of cellular sorting factors for the retrograde transport of vDNA away from degradative endo/lysosomal compartments to the Golgi, prior to mitosis-dependent nuclear accumulation of L2/vDNA. An overview of current models of HPV entry, subcellular trafficking, and the role of L2 during initial infection is provided below, highlighting unresolved questions and gaps in knowledge.

Original languageEnglish (US)
Article number370
JournalViruses
Volume9
Issue number12
DOIs
StatePublished - Dec 1 2017

Fingerprint

Capsid Proteins
Genome
Infection
Viral Genome
Cell Nucleus
Mitosis
Proteins

Keywords

  • Fusion peptide
  • Gamma secretase
  • HPV16
  • Human papillomavirus
  • L2
  • Membrane penetration
  • Mitosis
  • Retromer
  • Subcellular trafficking
  • Toxin
  • Translocation
  • Transmembrane domain

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

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abstract = "Since 2012, our understanding of human papillomavirus (HPV) subcellular trafficking has undergone a drastic paradigm shift. Work from multiple laboratories has revealed that HPV has evolved a unique means to deliver its viral genome (vDNA) to the cell nucleus, relying on myriad host cell proteins and processes. The major breakthrough finding from these recent endeavors has been the realization of L2-dependent utilization of cellular sorting factors for the retrograde transport of vDNA away from degradative endo/lysosomal compartments to the Golgi, prior to mitosis-dependent nuclear accumulation of L2/vDNA. An overview of current models of HPV entry, subcellular trafficking, and the role of L2 during initial infection is provided below, highlighting unresolved questions and gaps in knowledge.",
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