Subchronic haloperidol administration decreases aminopeptidase N activity and [Met5]enkephalin metabolism in rat striatum and cortex

Christopher S. Konkoy, Stephen M. Waters, Thomas P. Davis

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Previously we have shown that subchronic intraperitoneal (i.p.) administration of haloperidol decreases the degradation of [Met5]enkephalin by regional brain slices (Waters et al., 1995, J. Pharmacol. Exp. Ther. 274, 783). In the present study, subchronic (7-day i.p.) administration of haloperidol (1 mg/kg) decreased the accumulation of aminopeptidase-derived fragments Tyr and Gly-Gly-Phe-Met on cortical and striatal slices. The accumulation of Tyr-Gly-Gly, however, was not altered by haloperidol treatment on slices from either region. Further, aminopeptidase N activity was decreased in P2 membranes isolated from either the cortex or striatum of haloperidol-treated animals. These data suggest that the haloperidol-induced decrease in [Met5]enkephalin metabolism results, at least in part, from a reduction in the activity of aminopeptidase N.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalEuropean Journal of Pharmacology
Volume297
Issue number1-2
DOIs
StatePublished - Feb 15 1996

Keywords

  • Aminopeptidase N
  • Enkephalin
  • Haloperidol
  • Neuroleptic
  • Neuropeptide

ASJC Scopus subject areas

  • Pharmacology

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