Abstract
Previously we have shown that subchronic intraperitoneal (i.p.) administration of haloperidol decreases the degradation of [Met5]enkephalin by regional brain slices (Waters et al., 1995, J. Pharmacol. Exp. Ther. 274, 783). In the present study, subchronic (7-day i.p.) administration of haloperidol (1 mg/kg) decreased the accumulation of aminopeptidase-derived fragments Tyr and Gly-Gly-Phe-Met on cortical and striatal slices. The accumulation of Tyr-Gly-Gly, however, was not altered by haloperidol treatment on slices from either region. Further, aminopeptidase N activity was decreased in P2 membranes isolated from either the cortex or striatum of haloperidol-treated animals. These data suggest that the haloperidol-induced decrease in [Met5]enkephalin metabolism results, at least in part, from a reduction in the activity of aminopeptidase N.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 47-51 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 297 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Feb 15 1996 |
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Keywords
- Aminopeptidase N
- Enkephalin
- Haloperidol
- Neuroleptic
- Neuropeptide
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Subchronic haloperidol administration decreases aminopeptidase N activity and [Met5]enkephalin metabolism in rat striatum and cortex. / Konkoy, Christopher S.; Waters, Stephen M.; Davis, Thomas P.
In: European Journal of Pharmacology, Vol. 297, No. 1-2, 15.02.1996, p. 47-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Subchronic haloperidol administration decreases aminopeptidase N activity and [Met5]enkephalin metabolism in rat striatum and cortex
AU - Konkoy, Christopher S.
AU - Waters, Stephen M.
AU - Davis, Thomas P
PY - 1996/2/15
Y1 - 1996/2/15
N2 - Previously we have shown that subchronic intraperitoneal (i.p.) administration of haloperidol decreases the degradation of [Met5]enkephalin by regional brain slices (Waters et al., 1995, J. Pharmacol. Exp. Ther. 274, 783). In the present study, subchronic (7-day i.p.) administration of haloperidol (1 mg/kg) decreased the accumulation of aminopeptidase-derived fragments Tyr and Gly-Gly-Phe-Met on cortical and striatal slices. The accumulation of Tyr-Gly-Gly, however, was not altered by haloperidol treatment on slices from either region. Further, aminopeptidase N activity was decreased in P2 membranes isolated from either the cortex or striatum of haloperidol-treated animals. These data suggest that the haloperidol-induced decrease in [Met5]enkephalin metabolism results, at least in part, from a reduction in the activity of aminopeptidase N.
AB - Previously we have shown that subchronic intraperitoneal (i.p.) administration of haloperidol decreases the degradation of [Met5]enkephalin by regional brain slices (Waters et al., 1995, J. Pharmacol. Exp. Ther. 274, 783). In the present study, subchronic (7-day i.p.) administration of haloperidol (1 mg/kg) decreased the accumulation of aminopeptidase-derived fragments Tyr and Gly-Gly-Phe-Met on cortical and striatal slices. The accumulation of Tyr-Gly-Gly, however, was not altered by haloperidol treatment on slices from either region. Further, aminopeptidase N activity was decreased in P2 membranes isolated from either the cortex or striatum of haloperidol-treated animals. These data suggest that the haloperidol-induced decrease in [Met5]enkephalin metabolism results, at least in part, from a reduction in the activity of aminopeptidase N.
KW - Aminopeptidase N
KW - Enkephalin
KW - Haloperidol
KW - Neuroleptic
KW - Neuropeptide
UR - http://www.scopus.com/inward/record.url?scp=0030043285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030043285&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(95)00827-6
DO - 10.1016/0014-2999(95)00827-6
M3 - Article
C2 - 8851165
AN - SCOPUS:0030043285
VL - 297
SP - 47
EP - 51
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1-2
ER -