Submicron decafluorobutane phase-change contrast agents generated by microbubble condensation

Paul S. Sheeran, Samantha Luois, Terry O Matsunaga, Paul A. Dayton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Microbubbles (MBs) on the order of 1 - 5 microns have the ability to circulate in the vascular space with sufficient scattering ability to be used as ultrasound contrast and molecular imaging agents. However, for the purposes of extravascular ultrasound imaging, MBs are too large to pass through the endothelial gap junctions of leaky tumor vasculature. Bubbles on the order of 100s of nanometers may extravasate, but would be too small to elicit sufficient backscatter. Previously, we developed stabilized micron-sized decafluorobutane (DFB, bp = -1.1°C) droplets via extrusion at low temperatures for acoustic droplet activation that required less activation energy than similarly sized droplets of higher boiling-point perfluorocarbons. We have extended this by developing a unique method of producing sub-micron sized DFB droplets (200 - 300 nm) that will be sufficiently stable to diffuse through endothelial gap junctions, yet labile enough to undergo ADV at relatively low acoustic intensities. This method utilizes a simple yet novel technique involving compression of pre-formed DFB MBs at reduced temperatures. The simplicity of the method shows promise for future extension to molecular imaging as well as gene/drug delivery.

Original languageEnglish (US)
Title of host publicationIEEE International Ultrasonics Symposium, IUS
Pages636-639
Number of pages4
DOIs
StatePublished - 2011
Event2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States
Duration: Oct 18 2011Oct 21 2011

Other

Other2011 IEEE International Ultrasonics Symposium, IUS 2011
CountryUnited States
CityOrlando, FL
Period10/18/1110/21/11

Fingerprint

condensation
acoustics
genes
boiling
delivery
drugs
bubbles
tumors
activation
activation energy
scattering
temperature

Keywords

  • condensation
  • contrast agent
  • perfluorocarbon droplet
  • ultrasound
  • vaporization

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Sheeran, P. S., Luois, S., Matsunaga, T. O., & Dayton, P. A. (2011). Submicron decafluorobutane phase-change contrast agents generated by microbubble condensation. In IEEE International Ultrasonics Symposium, IUS (pp. 636-639). [6293281] https://doi.org/10.1109/ULTSYM.2011.0154

Submicron decafluorobutane phase-change contrast agents generated by microbubble condensation. / Sheeran, Paul S.; Luois, Samantha; Matsunaga, Terry O; Dayton, Paul A.

IEEE International Ultrasonics Symposium, IUS. 2011. p. 636-639 6293281.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sheeran, PS, Luois, S, Matsunaga, TO & Dayton, PA 2011, Submicron decafluorobutane phase-change contrast agents generated by microbubble condensation. in IEEE International Ultrasonics Symposium, IUS., 6293281, pp. 636-639, 2011 IEEE International Ultrasonics Symposium, IUS 2011, Orlando, FL, United States, 10/18/11. https://doi.org/10.1109/ULTSYM.2011.0154
Sheeran PS, Luois S, Matsunaga TO, Dayton PA. Submicron decafluorobutane phase-change contrast agents generated by microbubble condensation. In IEEE International Ultrasonics Symposium, IUS. 2011. p. 636-639. 6293281 https://doi.org/10.1109/ULTSYM.2011.0154
Sheeran, Paul S. ; Luois, Samantha ; Matsunaga, Terry O ; Dayton, Paul A. / Submicron decafluorobutane phase-change contrast agents generated by microbubble condensation. IEEE International Ultrasonics Symposium, IUS. 2011. pp. 636-639
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