Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials

Alex S. Willoughby, Gui Shuang Ying, Cynthia A. Toth, Maureen G. Maguire, Russell E. Burns, Juan E. Grunwald, Ebenezer Daniel, Glenn J. Jaffe, David F. Williams, Sara Beardsley, Steven Bennett, Herbert Cantrill, Carmen Chan-Tram, Holly Cheshier, Kathyrn Damato, John Davies, Sundeep Dev, Julianne Enloe, Gennaro Follano, Peggy Gilbert & 842 others Jill Johnson, Tori Jones, Lisa Mayleben, Robert Mittra, Martha Moos, Ryan Neist, Neal Oestreich, Polly Quiram, Robert Ramsay, Edwin Ryan, Stephanie Schindeldecker, John Snater, Trenise Steele, Dwight Selders, Jessica Tonsfeldt, Shelly Valardi, Gary Edd Fish, Hank A. Aguado, Sally Arceneaux, Jean Arnwine, Kim Bell, Tina Bell, Bob Boleman, Patricia Bradley, David Callanan, Lori Coors, Jodi Creighton, Timothy Crew, Kimberly Cummings, Christopher Dock, Karen Duignan, Dwain Fuller, Keith Gray, Betsy Hendrix, Nicholas Hesse, Diana Jaramillo, Bradley Jost, Sandy Lash, Laura Lonsdale, Michael Mackens, Karin Mutz, Michael Potts, Brenda Sanchez, William Snyder, Wayne Solley, Carrie Tarter, Robert Wang, Patrick Williams, Stephen L. Perkins, Nicholas Anderson, Ann Arnold, Paul Blais, Joseph Googe, Tina T. Higdon, Cecile Hunt, Mary Johnson, James Miller, Misty Moore, Charity K. Morris, Christopher Morris, Sarah Oelrich, Kristina Oliver, Vicky Seitz, Jerry Whetstone, Bernard H. Doft, Jay Bedel, Robert Bergren, Ann Borthwick, Paul Conrad, Amanda Fec, Christina Fulwylie, Willia Ingram, Shawnique Latham, Gina Lester, Judy Liu, Louis Lobes, Nicole M. Lucko, Holly Mechling, Lori Merlotti, Keith McBroom, Karl Olsen, Danielle Puskas, Pamela Rath, Maria Schmucker, Lynn Schueckler, Christina Schultz, Heather Shultz, David Steinberg, Avni Vyas, Kim Whale, Kimberly Yeckel, David H. Orth, Linda S. Arredondo, Susan Brown, Barbara J. Ciscato, Joseph M. Civantos, Celeste Figliulo, Sohail Hasan, Belinda Kosinski, Dan Muir, Kiersten Nelson, Kirk Packo, John S. Pollack, Kourous Rezaei, Gina Shelton, Shannya Townsend-Patrick, Marian Walsh, H. Richard McDonald, Nina Ansari, Amanda Bye, Arthur D. Fu, Sean Grout, Chad Indermill, Robert N. Johnson, J. Michael Jumper, Silvia Linares, Brandon J. Lujan, Ames Munden, Meredith Persons, Rosa Rodriguez, Jennifer M. Rose, Brandi Teske, Yesmin Urias, Stephen Young, Richard F. Dreyer, Howard Daniel, Michele Connaughton, Irvin Handelman, Stephen Hobbs, Christine Hoerner, Dawn Hudson, Marcia Kopfer, Michael Lee, Craig Lemley, Joe Logan, Colin Ma, Christophe Mallet, Amanda Milliron, Mark Peters, Harry Wohlsein, Joel A. Pearlman, Margo Andrews, Melissa Bartlett, Nanette Carlson, Emily Cox, Robert Equi, Marta Gonzalez, Sophia Griffin, Fran Hogue, Lance Kennedy, Lana Kryuchkov, Carmen Lopez, Danny Lopez, Bertha Luevano, Erin McKenna, Arun Patel, Brian Reed, Nyla Secor, Iris R. Sison, Tony Tsai, Nina Varghis, Brooke Waller, Robert Wendel, Reina Yebra, Daniel B. Roth, Jane Deinzer, Howard Fine, Flory Green, Stuart Green, Bruce Keyser, Steven Leff, Amy Leviton, Amy Martir, Kristin Mosenthine, Starr Muscle, Linda Okoren, Sandy Parker, Jonathan Prenner, Nancy Price, Deana Rogers, Linda Rosas, Alex Schlosser, Loretta Studenko, Thea Tantum, Harold Wheatley, Michael T. Trese, Thomas Aaberg, Denis Bezaire, Craig Bridges, Doug Bryant, Antonio Capone, Michelle Coleman, Christina Consolo, Cindy Cook, Candice Dulong, Bruce Garretson, Tracy Grooten, Julie Hammersley, Tarek Hassan, Heather Jessick, Nanette Jones, Crystal Kinsman, Jennifer Krumlauf, Sandy Lewis, Heather Locke, Alan Margherio, Debra Markus, Tanya Marsh, Serena Neal, Amy Noffke, Kean Oh, Clarence Pence, Lisa Preston, Paul Raphaelian, Virginia R. Regan, Peter Roberts, Alan Ruby, Ramin Sarrafizadeh, Marissa Scherf, Sarita Scott, Scott Sneed, Lisa Staples, Brad Terry, Matthew T. Trese, Joan Videtich, George Williams, Mary Zajechowski, Daniel P. Joseph, Kevin Blinder, Lynda Boyd, Sarah Buckley, Meaghan Crow, Amanda Dinatale, Nicholas Engelbrecht, Bridget Forke, Dana Gabel, Gilbert Grand, Jennifer Grillion-Cerone, Nancy Holekamp, Charlotte Kelly, Ginny Nobel, Kelly Pepple, Matt Raeber, P. Kumar Rao, Tammy Ressel, Steven Schremp, Merrilee Sgorlon, Shantia Shears, Matthew Thomas, Cathy Timma, Annette Vaughn, Carolyn Walters, Rhonda Weeks, Jarrod Wehmeier, Tim Wright, Daniel M. Berinstein, Aida Ayyad, Mohammed K. Barazi, Erica Bickhart, Tracey Brady, Lisa Byank, Alysia Cronise, Vanessa Denny, Courtney Dunn, Michael Flory, Robert Frantz, Richard A. Garfinkel, William Gilbert, Michael M. Lai, Alexander Melamud, Janine Newgen, Shamekia Newton, Debbie Oliver, Michael Osman, Reginald Sanders, Manfred Von Fricken, Pravin Dugel, Sandra Arenas, Gabe Balea, Dayna Bartoli, John Bucci, Jennifer A. Cornelius, Scheleen Dickens, Don Doherty, Heather Dunlap, David Goldenberg, Karim Jamal, Norma Jimenez, Nicole Kavanagh, Derek Kunimoto, John Martin, Jessica Miner, Sarah Mobley, Donald Park, Edward Quinlan, Jack Sipperley, Carol Slagle, Danielle Smith, Miguelina Yafchak, Rohana Yager, Christina J. Flaxel, Steven Bailey, Peter Francis, Chris Howell, Thomas Hwang, Shirley Ira, Michael Klein, Andreas Lauer, Teresa Liesegang, Ann Lundquist, Sarah Nolte, Susan K. Nolte, Scott Pickell, Susan Pope, Joseph Rossi, Mitchell Schain, Peter Steinkamp, Maureen D. Toomey, Debora Vahrenwald, Kelly West, Baker Hubbard, Stacey Andelman, Chris Bergstrom, Judy Brower, Blaine Cribbs, Linda Curtis, Jannah Dobbs, Lindreth Dubois, Jessica Gaultney, Deborah Gibbs, Debora Jordan, Donna Leef, Daniel F. Martin, Robert Myles, Timothy Olsen, Bryan Schwent, Sunil Srivastava, Rhonda Waldron, Andrew N. Antoszyk, Uma Balasubramaniam, Danielle Brooks, Justin Brown, David Browning, Loraine Clark, Sarah Ennis, Susannah Held, Jennifer V. Helms, Jenna Herby, Angie Karow, Pearl Leotaud, Caterina Massimino, Donna McClain, Michael McOwen, Jennifer Mindel, Candace Pereira, Rachel Pierce, Michele Powers, Angela Price, Jason Rohrer, Jason Sanders, Robert L. Avery, Kelly Avery, Jessica Basefsky, Liz Beckner, Alessandro Castellarin, Stephen Couvillion, Jack Giust, Matthew Giust, Maan Nasir, Dante Pieramici, Melvin Rabena, Sarah Risard, Robert See, Jerry Smith, Lisha Wan, Sophie J. Bakri, Nakhleh Abu-Yaghi, Andrew Barkmeier, Karin Berg, Jean Burrington, Albert Edwards, Shannon Goddard, Shannon Howard, Raymond Iezzi, Denise Lewison, Thomas Link, Colin A. McCannel, Joan Overend, John Pach, Margaret Ruszczyk, Ryan Shultz, Cindy Stephan, Diane Vogen, Reagan H. Bradford, Vanessa Bergman, Russ Burris, Amanda Butt, Beth Daniels, Connie Dwiggins, Stephen Fransen, Tiffany Guerrero, Darin Haivala, Amy Harris, Sonny Icks, Ronald Kingsley, Lena Redden, Rob Richmond, Brittany Ross, Kammerin White, Misty Youngberg, Trexler M. Topping, Sandy Chong, Mary Ciotti, Tina Cleary, Emily Corey, Dennis Donovan, Albert Frederick, Lesley Freese, Margaret Graham, Natalya Gud, Taneika Howard, Mike Jones, Michael Morley, Katie Moses, Jen Stone, Robin Ty, Torsten Wiegand, Lindsey Williams, Beth Winder, Carl C. Awh, Michelle Amonette, Everton Arrindell, Dena Beck, Brandon Busbee, Amy Dilback, Sara Downs, Allison Guidry, Gary Gutow, Jackey Hardin, Sarah Hines, Emily Hutchins, Kim Lacivita, Ashley Lester, Larry Malott, Maryann McCain, Jayme Miracle, Kenneth Moffat, Lacy Palazzotta, Kelly Robinson, Peter Sonkin, Alecia Travis, Roy Trent Wallace, Kelly J. Winters, Julia Wray, April E. Harris, Mari Bunnell, Katrina Crooks, Rebecca Fitzgerald, Cameron Javid, Corin Kew, Erica Kill, Patricia Kline, Janet Kreienkamp, Maricruz Martinez, Roy Ann Moore, Egbert Saavedra, Luanne Taylor, Mark Walsh, Larry Wilson, Thomas A. Ciulla, Ellen Coyle, Tonya Harrington, Charlotte Harris, Cindi Hood, Ingrid Kerr, Raj Maturi, Dawn Moore, Stephanie Morrow, Jennifer Savage, Bethany Sink, Tom Steele, Neelam Thukral, Janet Wilburn, Joseph P. Walker, Jennifer Banks, Debbie Ciampaglia, Danielle Dyshanowitz, Jennifer Frederick, A. Tom Ghuman, Richard Grodin, Cheryl Kiesel, Eileen Knips, Jonathan McCue, Maria Ortiz, Crystal Peters, Paul Raskauskas, Etienne Schoeman, Ashish Sharma, Glenn Wing, Rebecca Youngblood, Suresh R. Chandra, Michael Altaweel, Barbara Blodi, Kathryn Burke, Kristine A. Dietzman, Justin Gottlieb, Gene Knutson, Denise Krolnik, T. Michael Nork, Shelly Olson, John Peterson, Sandra Reed, Barbara Soderling, Guy Somers, Thomas Stevens, Angela Wealti, Srilaxmi Bearelly, Brenda Branchaud, Joyce W. Bryant, Sara Crowell, Sharon Fekrat, Merritt Gammage, Cheala Harrison, Sarah Jones, Noreen McClain, Brooks McCuen, Prithvi Mruthyunjaya, Jeanne Queen, Neeru Sarin, Cindy Skalak, Marriner Skelly, Ivan Suner, Ronnie Tomany, Lauren Welch, Susanna S. Park, Allison Cassidy, Karishma Chandra, Idalew Good, Katrina Imson, Sashi Kaur, Helen Metzler, Lawrence Morse, Ellen Redenbo, Marisa Salvador, David Telander, Mark Thomas, Cindy Wallace, Charles C. Barr, Amanda Battcher, Michelle Bottorff, Mary Chasteen, Kelly Clark, Diane Denning, Debra Schoen, Amy Schultz, Evie Tempel, Lisa Wheeler, Greg K. Whittington, Thomas W. Stone, Todd Blevins, Michelle Buck, Lynn Cruz, Wanda Heath, Diana Holcomb, Rick Isernhagen, Terri Kidd, John Kitchens, Cathy Sears, Ed Slade, Jeanne Van Arsdall, Brenda Vanhoose, Jenny Wolfe, William Wood, John Zilis, Carol Crooks, Larry Disney, Mimi Liu, Stephen Petty, Sandra Sall, James C. Folk, Tracy Aly, Abby Brotherton, Douglas Critser, Connie J. Hinz, Stefani Karakas, Valerie Kirschner, Cheyanne Lester, Cindy Montague, Stephen Russell, Heather Stockman, Barbara Taylor, Randy Verdick, Jean Walshire, John T. Thompson, Barbara Connell, Maryanth Constantine, John L. Davis, Gwen Holsapple, Lisa Hunter, C. Nicki Lenane, Robin Mitchell, Leslie Russel, Raymond Sjaarda, David M. Brown, Matthew Benz, Llewellyn Burns, Jolene G. Carranza, Richard Fish, Debra Goates, Shayla Hay, Theresa Jeffers, Eric Kegley, Dallas Kubecka, Stacy McGilvra, Beau Richter, Veronica Sneed, Cary Stoever, Isabell Tellez, Tien Wong, Ivana Kim, Christopher Andreoli, Leslie Barresi, Sarah Brett, Charlene Callahan, Karen Capaccioli, William Carli, Matthew Coppola, Nicholas Emmanuel, Claudia Evans, Anna Fagan, Marcia Grillo, John Head, Troy Kieser, Elaine Lee, Ursula Lord, Edward Miretsky, Kate Palitsch, Todd Petrin, Liz Reader, Svetlana Reznichenko, Mary Robertson, Justin Smith, Demetrios Vavvas, John Wells, Cassie Cahill, W. Lloyd Clark, Kayla Henry, David Johnson, Peggy Miller, Ladetrick Oliver, Robbin Spivey, Tiffany Swinford, Mallie Taylor, Michael Lambert, Kris Chase, Debbie Fredrickson, Joseph Khawly, Valerie Lazarte, Donald Lowd, Pam Miller, Arthur Willis, Philip J. Ferrone, Miguel Almonte, Rachel Arnott, Ingrid Aviles, Sheri Carbon, Michael Chitjian, Kristen Damore, Christin Elliott, David Fastenberg, Barry Golub, Kenneth Graham, Annmarie Lavorna, Laura Murphy, Amanda Palomo, Christina Puglisi, David Rhee, Juan Romero, Brett Rosenblatt, Glenda Salcedo, Marianne Schlameuss, Eric Shakin, Vasanti Sookhai, Richard Kaiser, Elizabeth Affel, Gary Brown, Christina Centinaro, Deborah Fine, Mitchell Fineman, Michele Formoso, Sunir Garg, Lisa Grande, Carolyn Herbert, Allen Ho, Jason Hsu, Maryann Jay, Lisa Lavetsky, Elaine Liebenbaum, Joseph Maguire, Julia Monsonego, Lucia O'Connor, Lisa Pierce, Carl Regillo, Maria Rosario, Marc Spirn, James Vander, Jennifer Walsh, Frederick H. Davidorf, Amanda Barnett, Susie Chang, John B Christoforidis, Joy Elliott, Heather Justice, Alan Letson, Kathryne McKinney, Jeri Perry, Jill A. Salerno, Scott Savage, Stephen Shelley, Lawrence J. Singerman, Joseph Coney, John Dubois, Kimberly Dubois, Gregg Greanoff, Dianne Himmelman, Mary Ilc, Elizabeth McNamara, Michael Novak, Scott Pendergast, Susan Rath, Sheila Smith-Brewer, Vivian Tanner, Diane E. Weiss, Hernando Zegarra, Lawrence Halperin, Patricia Aramayo, Mandeep Dhalla, Brian Fernandez, Cindy Fernandez, Jaclyn Lopez, Monica Lopez, Jamie Mariano, Kellie Murphy, Clifford Sherley, Rita Veksler, Firas Rahhal, Razmig Babikian, David Boyer, Sepideh Hami, Jeff Kessinger, Janet Kurokouchi, Saba Mukarram, Sarah Pachman, Eric Protacio, Julio Sierra, Homayoun Tabandeh, Adam Zamboni, Michael Elman, Jennifer Belz, Tammy Butcher, Theresa Cain, Teresa Coffey, Dena Firestone, Nancy Gore, Pamela Singletary, Peter Sotirakos, Joann Starr, Travis A. Meredith, Cassandra J. Barnhart, Debra Cantrell, Ronalyn Esquejo-Leon, Odette Houghton, Harpreet Kaur, Fatoumatta Ndure, Ronald Glatzer, Leonard Joffe, Reid Schindler, Stuart L. Fine, Marilyn Katz, Mary Brightwell-Arnold, Ruchira Glaser, Judith Hall, Sandra Harkins, Jiayan Huang, Alexander Khvatov, Kathy McWilliams, Ellen Peskin, Maxwell Pistilli, Susan Ryan, Allison Schnader, Jennifer Afrani-Sakyi, Brannon Balsley, Linda S. Bennett, Adam Brooks, Adrienne Brower-Lingsch, Lori Bruce, Dee Busian, John Choong, Lindsey Cloaninger, Francis Char DeCroos, Emily Dubois, Mays El-Dairi, Sarah Gach, Katelyn Hall, Terry Hawks, Chengchenh Huang, Cindy Heydary, Alexander Ho, Shashi Kini, Michelle McCall, Daaimah Muhammad, Jayne Nicholson, Pamela Rieves, Kelly Shields, Adam Specker, Sandra Stinnett, Sujatha Subramaniam, Patrick Tenbrink, Aaron Towe, Kimberly Welch, Natasha Williams, Katrina Winter, Ellen Young, Judith Alexander, Elisabeth Flannagan, E. Revell Martin, Candace Parker, Krista Sepielli, Tom Shannon, Claressa Whearry, Maryann Redford, Marcia R. Kopfer, Frederick L. Ferris, Joan Dupont, Lawrence M. Friedman, Susan B. Bressler, David L. Demets, Martin Friedlander, Mark W. Johnson, Anne Lindblad, Douglas W. Losordo, Franklin G. Miller

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Purpose To evaluate the association of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA), and scar in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Design Prospective cohort study within a randomized clinical trial. Participants The 1185 CATT participants. Methods Masked readers graded scar and GA on fundus photography and fluorescein angiography and graded SHRM on time-domain and spectral-domain (SD) optical coherence tomography (OCT) throughout 104 weeks. Measurements of SHRM height and width in the fovea, within the center 1 mm2, or outside the center 1mm2 were obtained on SD OCT images at 56 (n = 76) and 104 (n = 66) weeks. Main Outcome Measures Presence of SHRM, as well as location and size, and associations with VA, scar, and GA. Results Among CATT participants, the percentage with SHRM at enrollment was 77%, decreasing to 68% at 4 weeks after treatment and to 54% at 104 weeks. At 104 weeks, scar was present more often in eyes with persistent SHRM than in eyes with SHRM that resolved (64% vs. 31%; P <0.0001). Among eyes with detailed evaluation of SHRM at weeks 56 (n = 76) and 104 (n = 66), mean VA letter score was 73.5 (standard error [SE], 2.8), 73.1 (SE, 3.4), 65.3 (SE, 3.5), and 63.9 (SE, 3.7) when SHRM was absent, present outside the central 1 mm2, present within the central 1 mm2 but not the foveal center, or present at the foveal center (P = 0.02), respectively. When SHRM was present, the median maximum height under the fovea, within the central 1 mm2 including the fovea and anywhere within the scan, was 86 μm, 120 μm, and 122 μm, respectively. Visual acuity was decreased with greater SHRM height and width (P <0.05). Conclusions In eyes with neovascular age-related macular degeneration (AMD), SHRM is common and often persists after anti-vascular endothelial growth factor treatment. At 2 years, eyes with scar were more likely to have SHRM than other eyes. Greater SHRM dimensions were associated with worse VA. In eyes with neovascular AMD, SHRM is an important morphologic biomarker.

Original languageEnglish (US)
Pages (from-to)1846-1853
Number of pages8
JournalOphthalmology
Volume122
Issue number9
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

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Macular Degeneration
Geographic Atrophy
Visual Acuity
Cicatrix
Optical Coherence Tomography
Fluorescein Angiography
Photography
Vascular Endothelial Growth Factor A
Cohort Studies
Randomized Controlled Trials
Biomarkers
Outcome Assessment (Health Care)
Prospective Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Willoughby, A. S., Ying, G. S., Toth, C. A., Maguire, M. G., Burns, R. E., Grunwald, J. E., ... Miller, F. G. (2015). Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials. Ophthalmology, 122(9), 1846-1853. https://doi.org/10.1016/j.ophtha.2015.05.042

Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials. / Willoughby, Alex S.; Ying, Gui Shuang; Toth, Cynthia A.; Maguire, Maureen G.; Burns, Russell E.; Grunwald, Juan E.; Daniel, Ebenezer; Jaffe, Glenn J.; Williams, David F.; Beardsley, Sara; Bennett, Steven; Cantrill, Herbert; Chan-Tram, Carmen; Cheshier, Holly; Damato, Kathyrn; Davies, John; Dev, Sundeep; Enloe, Julianne; Follano, Gennaro; Gilbert, Peggy; Johnson, Jill; Jones, Tori; Mayleben, Lisa; Mittra, Robert; Moos, Martha; Neist, Ryan; Oestreich, Neal; Quiram, Polly; Ramsay, Robert; Ryan, Edwin; Schindeldecker, Stephanie; Snater, John; Steele, Trenise; Selders, Dwight; Tonsfeldt, Jessica; Valardi, Shelly; Fish, Gary Edd; Aguado, Hank A.; Arceneaux, Sally; Arnwine, Jean; Bell, Kim; Bell, Tina; Boleman, Bob; Bradley, Patricia; Callanan, David; Coors, Lori; Creighton, Jodi; Crew, Timothy; Cummings, Kimberly; Dock, Christopher; Duignan, Karen; Fuller, Dwain; Gray, Keith; Hendrix, Betsy; Hesse, Nicholas; Jaramillo, Diana; Jost, Bradley; Lash, Sandy; Lonsdale, Laura; Mackens, Michael; Mutz, Karin; Potts, Michael; Sanchez, Brenda; Snyder, William; Solley, Wayne; Tarter, Carrie; Wang, Robert; Williams, Patrick; Perkins, Stephen L.; Anderson, Nicholas; Arnold, Ann; Blais, Paul; Googe, Joseph; Higdon, Tina T.; Hunt, Cecile; Johnson, Mary; Miller, James; Moore, Misty; Morris, Charity K.; Morris, Christopher; Oelrich, Sarah; Oliver, Kristina; Seitz, Vicky; Whetstone, Jerry; Doft, Bernard H.; Bedel, Jay; Bergren, Robert; Borthwick, Ann; Conrad, Paul; Fec, Amanda; Fulwylie, Christina; Ingram, Willia; Latham, Shawnique; Lester, Gina; Liu, Judy; Lobes, Louis; Lucko, Nicole M.; Mechling, Holly; Merlotti, Lori; McBroom, Keith; Olsen, Karl; Puskas, Danielle; Rath, Pamela; Schmucker, Maria; Schueckler, Lynn; Schultz, Christina; Shultz, Heather; Steinberg, David; Vyas, Avni; Whale, Kim; Yeckel, Kimberly; Orth, David H.; Arredondo, Linda S.; Brown, Susan; Ciscato, Barbara J.; Civantos, Joseph M.; Figliulo, Celeste; Hasan, Sohail; Kosinski, Belinda; Muir, Dan; Nelson, Kiersten; Packo, Kirk; Pollack, John S.; Rezaei, Kourous; Shelton, Gina; Townsend-Patrick, Shannya; Walsh, Marian; Richard McDonald, H.; Ansari, Nina; Bye, Amanda; Fu, Arthur D.; Grout, Sean; Indermill, Chad; Johnson, Robert N.; Michael Jumper, J.; Linares, Silvia; Lujan, Brandon J.; Munden, Ames; Persons, Meredith; Rodriguez, Rosa; Rose, Jennifer M.; Teske, Brandi; Urias, Yesmin; Young, Stephen; Dreyer, Richard F.; Daniel, Howard; Connaughton, Michele; Handelman, Irvin; Hobbs, Stephen; Hoerner, Christine; Hudson, Dawn; Kopfer, Marcia; Lee, Michael; Lemley, Craig; Logan, Joe; Ma, Colin; Mallet, Christophe; Milliron, Amanda; Peters, Mark; Wohlsein, Harry; Pearlman, Joel A.; Andrews, Margo; Bartlett, Melissa; Carlson, Nanette; Cox, Emily; Equi, Robert; Gonzalez, Marta; Griffin, Sophia; Hogue, Fran; Kennedy, Lance; Kryuchkov, Lana; Lopez, Carmen; Lopez, Danny; Luevano, Bertha; McKenna, Erin; Patel, Arun; Reed, Brian; Secor, Nyla; Sison, Iris R.; Tsai, Tony; Varghis, Nina; Waller, Brooke; Wendel, Robert; Yebra, Reina; Roth, Daniel B.; Deinzer, Jane; Fine, Howard; Green, Flory; Green, Stuart; Keyser, Bruce; Leff, Steven; Leviton, Amy; Martir, Amy; Mosenthine, Kristin; Muscle, Starr; Okoren, Linda; Parker, Sandy; Prenner, Jonathan; Price, Nancy; Rogers, Deana; Rosas, Linda; Schlosser, Alex; Studenko, Loretta; Tantum, Thea; Wheatley, Harold; Trese, Michael T.; Aaberg, Thomas; Bezaire, Denis; Bridges, Craig; Bryant, Doug; Capone, Antonio; Coleman, Michelle; Consolo, Christina; Cook, Cindy; Dulong, Candice; Garretson, Bruce; Grooten, Tracy; Hammersley, Julie; Hassan, Tarek; Jessick, Heather; Jones, Nanette; Kinsman, Crystal; Krumlauf, Jennifer; Lewis, Sandy; Locke, Heather; Margherio, Alan; Markus, Debra; Marsh, Tanya; Neal, Serena; Noffke, Amy; Oh, Kean; Pence, Clarence; Preston, Lisa; Raphaelian, Paul; Regan, Virginia R.; Roberts, Peter; Ruby, Alan; Sarrafizadeh, Ramin; Scherf, Marissa; Scott, Sarita; Sneed, Scott; Staples, Lisa; Terry, Brad; Trese, Matthew T.; Videtich, Joan; Williams, George; Zajechowski, Mary; Joseph, Daniel P.; Blinder, Kevin; Boyd, Lynda; Buckley, Sarah; Crow, Meaghan; Dinatale, Amanda; Engelbrecht, Nicholas; Forke, Bridget; Gabel, Dana; Grand, Gilbert; Grillion-Cerone, Jennifer; Holekamp, Nancy; Kelly, Charlotte; Nobel, Ginny; Pepple, Kelly; Raeber, Matt; Kumar Rao, P.; Ressel, Tammy; Schremp, Steven; Sgorlon, Merrilee; Shears, Shantia; Thomas, Matthew; Timma, Cathy; Vaughn, Annette; Walters, Carolyn; Weeks, Rhonda; Wehmeier, Jarrod; Wright, Tim; Berinstein, Daniel M.; Ayyad, Aida; Barazi, Mohammed K.; Bickhart, Erica; Brady, Tracey; Byank, Lisa; Cronise, Alysia; Denny, Vanessa; Dunn, Courtney; Flory, Michael; Frantz, Robert; Garfinkel, Richard A.; Gilbert, William; Lai, Michael M.; Melamud, Alexander; Newgen, Janine; Newton, Shamekia; Oliver, Debbie; Osman, Michael; Sanders, Reginald; Von Fricken, Manfred; Dugel, Pravin; Arenas, Sandra; Balea, Gabe; Bartoli, Dayna; Bucci, John; Cornelius, Jennifer A.; Dickens, Scheleen; Doherty, Don; Dunlap, Heather; Goldenberg, David; Jamal, Karim; Jimenez, Norma; Kavanagh, Nicole; Kunimoto, Derek; Martin, John; Miner, Jessica; Mobley, Sarah; Park, Donald; Quinlan, Edward; Sipperley, Jack; Slagle, Carol; Smith, Danielle; Yafchak, Miguelina; Yager, Rohana; Flaxel, Christina J.; Bailey, Steven; Francis, Peter; Howell, Chris; Hwang, Thomas; Ira, Shirley; Klein, Michael; Lauer, Andreas; Liesegang, Teresa; Lundquist, Ann; Nolte, Sarah; Nolte, Susan K.; Pickell, Scott; Pope, Susan; Rossi, Joseph; Schain, Mitchell; Steinkamp, Peter; Toomey, Maureen D.; Vahrenwald, Debora; West, Kelly; Hubbard, Baker; Andelman, Stacey; Bergstrom, Chris; Brower, Judy; Cribbs, Blaine; Curtis, Linda; Dobbs, Jannah; Dubois, Lindreth; Gaultney, Jessica; Gibbs, Deborah; Jordan, Debora; Leef, Donna; Martin, Daniel F.; Myles, Robert; Olsen, Timothy; Schwent, Bryan; Srivastava, Sunil; Waldron, Rhonda; Antoszyk, Andrew N.; Balasubramaniam, Uma; Brooks, Danielle; Brown, Justin; Browning, David; Clark, Loraine; Ennis, Sarah; Held, Susannah; Helms, Jennifer V.; Herby, Jenna; Karow, Angie; Leotaud, Pearl; Massimino, Caterina; McClain, Donna; McOwen, Michael; Mindel, Jennifer; Pereira, Candace; Pierce, Rachel; Powers, Michele; Price, Angela; Rohrer, Jason; Sanders, Jason; Avery, Robert L.; Avery, Kelly; Basefsky, Jessica; Beckner, Liz; Castellarin, Alessandro; Couvillion, Stephen; Giust, Jack; Giust, Matthew; Nasir, Maan; Pieramici, Dante; Rabena, Melvin; Risard, Sarah; See, Robert; Smith, Jerry; Wan, Lisha; Bakri, Sophie J.; Abu-Yaghi, Nakhleh; Barkmeier, Andrew; Berg, Karin; Burrington, Jean; Edwards, Albert; Goddard, Shannon; Howard, Shannon; Iezzi, Raymond; Lewison, Denise; Link, Thomas; McCannel, Colin A.; Overend, Joan; Pach, John; Ruszczyk, Margaret; Shultz, Ryan; Stephan, Cindy; Vogen, Diane; Bradford, Reagan H.; Bergman, Vanessa; Burris, Russ; Butt, Amanda; Daniels, Beth; Dwiggins, Connie; Fransen, Stephen; Guerrero, Tiffany; Haivala, Darin; Harris, Amy; Icks, Sonny; Kingsley, Ronald; Redden, Lena; Richmond, Rob; Ross, Brittany; White, Kammerin; Youngberg, Misty; Topping, Trexler M.; Chong, Sandy; Ciotti, Mary; Cleary, Tina; Corey, Emily; Donovan, Dennis; Frederick, Albert; Freese, Lesley; Graham, Margaret; Gud, Natalya; Howard, Taneika; Jones, Mike; Morley, Michael; Moses, Katie; Stone, Jen; Ty, Robin; Wiegand, Torsten; Williams, Lindsey; Winder, Beth; Awh, Carl C.; Amonette, Michelle; Arrindell, Everton; Beck, Dena; Busbee, Brandon; Dilback, Amy; Downs, Sara; Guidry, Allison; Gutow, Gary; Hardin, Jackey; Hines, Sarah; Hutchins, Emily; Lacivita, Kim; Lester, Ashley; Malott, Larry; McCain, Maryann; Miracle, Jayme; Moffat, Kenneth; Palazzotta, Lacy; Robinson, Kelly; Sonkin, Peter; Travis, Alecia; Wallace, Roy Trent; Winters, Kelly J.; Wray, Julia; Harris, April E.; Bunnell, Mari; Crooks, Katrina; Fitzgerald, Rebecca; Javid, Cameron; Kew, Corin; Kill, Erica; Kline, Patricia; Kreienkamp, Janet; Martinez, Maricruz; Ann Moore, Roy; Saavedra, Egbert; Taylor, Luanne; Walsh, Mark; Wilson, Larry; Ciulla, Thomas A.; Coyle, Ellen; Harrington, Tonya; Harris, Charlotte; Hood, Cindi; Kerr, Ingrid; Maturi, Raj; Moore, Dawn; Morrow, Stephanie; Savage, Jennifer; Sink, Bethany; Steele, Tom; Thukral, Neelam; Wilburn, Janet; Walker, Joseph P.; Banks, Jennifer; Ciampaglia, Debbie; Dyshanowitz, Danielle; Frederick, Jennifer; Tom Ghuman, A.; Grodin, Richard; Kiesel, Cheryl; Knips, Eileen; McCue, Jonathan; Ortiz, Maria; Peters, Crystal; Raskauskas, Paul; Schoeman, Etienne; Sharma, Ashish; Wing, Glenn; Youngblood, Rebecca; Chandra, Suresh R.; Altaweel, Michael; Blodi, Barbara; Burke, Kathryn; Dietzman, Kristine A.; Gottlieb, Justin; Knutson, Gene; Krolnik, Denise; Michael Nork, T.; Olson, Shelly; Peterson, John; Reed, Sandra; Soderling, Barbara; Somers, Guy; Stevens, Thomas; Wealti, Angela; Bearelly, Srilaxmi; Branchaud, Brenda; Bryant, Joyce W.; Crowell, Sara; Fekrat, Sharon; Gammage, Merritt; Harrison, Cheala; Jones, Sarah; McClain, Noreen; McCuen, Brooks; Mruthyunjaya, Prithvi; Queen, Jeanne; Sarin, Neeru; Skalak, Cindy; Skelly, Marriner; Suner, Ivan; Tomany, Ronnie; Welch, Lauren; Park, Susanna S.; Cassidy, Allison; Chandra, Karishma; Good, Idalew; Imson, Katrina; Kaur, Sashi; Metzler, Helen; Morse, Lawrence; Redenbo, Ellen; Salvador, Marisa; Telander, David; Thomas, Mark; Wallace, Cindy; Barr, Charles C.; Battcher, Amanda; Bottorff, Michelle; Chasteen, Mary; Clark, Kelly; Denning, Diane; Schoen, Debra; Schultz, Amy; Tempel, Evie; Wheeler, Lisa; Whittington, Greg K.; Stone, Thomas W.; Blevins, Todd; Buck, Michelle; Cruz, Lynn; Heath, Wanda; Holcomb, Diana; Isernhagen, Rick; Kidd, Terri; Kitchens, John; Sears, Cathy; Slade, Ed; Van Arsdall, Jeanne; Vanhoose, Brenda; Wolfe, Jenny; Wood, William; Zilis, John; Crooks, Carol; Disney, Larry; Liu, Mimi; Petty, Stephen; Sall, Sandra; Folk, James C.; Aly, Tracy; Brotherton, Abby; Critser, Douglas; Hinz, Connie J.; Karakas, Stefani; Kirschner, Valerie; Lester, Cheyanne; Montague, Cindy; Russell, Stephen; Stockman, Heather; Taylor, Barbara; Verdick, Randy; Walshire, Jean; Thompson, John T.; Connell, Barbara; Constantine, Maryanth; Davis, John L.; Holsapple, Gwen; Hunter, Lisa; Lenane, C. Nicki; Mitchell, Robin; Russel, Leslie; Sjaarda, Raymond; Brown, David M.; Benz, Matthew; Burns, Llewellyn; Carranza, Jolene G.; Fish, Richard; Goates, Debra; Hay, Shayla; Jeffers, Theresa; Kegley, Eric; Kubecka, Dallas; McGilvra, Stacy; Richter, Beau; Sneed, Veronica; Stoever, Cary; Tellez, Isabell; Wong, Tien; Kim, Ivana; Andreoli, Christopher; Barresi, Leslie; Brett, Sarah; Callahan, Charlene; Capaccioli, Karen; Carli, William; Coppola, Matthew; Emmanuel, Nicholas; Evans, Claudia; Fagan, Anna; Grillo, Marcia; Head, John; Kieser, Troy; Lee, Elaine; Lord, Ursula; Miretsky, Edward; Palitsch, Kate; Petrin, Todd; Reader, Liz; Reznichenko, Svetlana; Robertson, Mary; Smith, Justin; Vavvas, Demetrios; Wells, John; Cahill, Cassie; Lloyd Clark, W.; Henry, Kayla; Johnson, David; Miller, Peggy; Oliver, Ladetrick; Spivey, Robbin; Swinford, Tiffany; Taylor, Mallie; Lambert, Michael; Chase, Kris; Fredrickson, Debbie; Khawly, Joseph; Lazarte, Valerie; Lowd, Donald; Miller, Pam; Willis, Arthur; Ferrone, Philip J.; Almonte, Miguel; Arnott, Rachel; Aviles, Ingrid; Carbon, Sheri; Chitjian, Michael; Damore, Kristen; Elliott, Christin; Fastenberg, David; Golub, Barry; Graham, Kenneth; Lavorna, Annmarie; Murphy, Laura; Palomo, Amanda; Puglisi, Christina; Rhee, David; Romero, Juan; Rosenblatt, Brett; Salcedo, Glenda; Schlameuss, Marianne; Shakin, Eric; Sookhai, Vasanti; Kaiser, Richard; Affel, Elizabeth; Brown, Gary; Centinaro, Christina; Fine, Deborah; Fineman, Mitchell; Formoso, Michele; Garg, Sunir; Grande, Lisa; Herbert, Carolyn; Ho, Allen; Hsu, Jason; Jay, Maryann; Lavetsky, Lisa; Liebenbaum, Elaine; Maguire, Joseph; Monsonego, Julia; O'Connor, Lucia; Pierce, Lisa; Regillo, Carl; Rosario, Maria; Spirn, Marc; Vander, James; Walsh, Jennifer; Davidorf, Frederick H.; Barnett, Amanda; Chang, Susie; Christoforidis, John B; Elliott, Joy; Justice, Heather; Letson, Alan; McKinney, Kathryne; Perry, Jeri; Salerno, Jill A.; Savage, Scott; Shelley, Stephen; Singerman, Lawrence J.; Coney, Joseph; Dubois, John; Dubois, Kimberly; Greanoff, Gregg; Himmelman, Dianne; Ilc, Mary; McNamara, Elizabeth; Novak, Michael; Pendergast, Scott; Rath, Susan; Smith-Brewer, Sheila; Tanner, Vivian; Weiss, Diane E.; Zegarra, Hernando; Halperin, Lawrence; Aramayo, Patricia; Dhalla, Mandeep; Fernandez, Brian; Fernandez, Cindy; Lopez, Jaclyn; Lopez, Monica; Mariano, Jamie; Murphy, Kellie; Sherley, Clifford; Veksler, Rita; Rahhal, Firas; Babikian, Razmig; Boyer, David; Hami, Sepideh; Kessinger, Jeff; Kurokouchi, Janet; Mukarram, Saba; Pachman, Sarah; Protacio, Eric; Sierra, Julio; Tabandeh, Homayoun; Zamboni, Adam; Elman, Michael; Belz, Jennifer; Butcher, Tammy; Cain, Theresa; Coffey, Teresa; Firestone, Dena; Gore, Nancy; Singletary, Pamela; Sotirakos, Peter; Starr, Joann; Meredith, Travis A.; Barnhart, Cassandra J.; Cantrell, Debra; Esquejo-Leon, Ronalyn; Houghton, Odette; Kaur, Harpreet; Ndure, Fatoumatta; Glatzer, Ronald; Joffe, Leonard; Schindler, Reid; Fine, Stuart L.; Katz, Marilyn; Brightwell-Arnold, Mary; Glaser, Ruchira; Hall, Judith; Harkins, Sandra; Huang, Jiayan; Khvatov, Alexander; McWilliams, Kathy; Peskin, Ellen; Pistilli, Maxwell; Ryan, Susan; Schnader, Allison; Afrani-Sakyi, Jennifer; Balsley, Brannon; Bennett, Linda S.; Brooks, Adam; Brower-Lingsch, Adrienne; Bruce, Lori; Busian, Dee; Choong, John; Cloaninger, Lindsey; DeCroos, Francis Char; Dubois, Emily; El-Dairi, Mays; Gach, Sarah; Hall, Katelyn; Hawks, Terry; Huang, Chengchenh; Heydary, Cindy; Ho, Alexander; Kini, Shashi; McCall, Michelle; Muhammad, Daaimah; Nicholson, Jayne; Rieves, Pamela; Shields, Kelly; Specker, Adam; Stinnett, Sandra; Subramaniam, Sujatha; Tenbrink, Patrick; Towe, Aaron; Welch, Kimberly; Williams, Natasha; Winter, Katrina; Young, Ellen; Alexander, Judith; Flannagan, Elisabeth; Martin, E. Revell; Parker, Candace; Sepielli, Krista; Shannon, Tom; Whearry, Claressa; Redford, Maryann; Kopfer, Marcia R.; Ferris, Frederick L.; Dupont, Joan; Friedman, Lawrence M.; Bressler, Susan B.; Demets, David L.; Friedlander, Martin; Johnson, Mark W.; Lindblad, Anne; Losordo, Douglas W.; Miller, Franklin G.

In: Ophthalmology, Vol. 122, No. 9, 01.09.2015, p. 1846-1853.

Research output: Contribution to journalArticle

Willoughby, AS, Ying, GS, Toth, CA, Maguire, MG, Burns, RE, Grunwald, JE, Daniel, E, Jaffe, GJ, Williams, DF, Beardsley, S, Bennett, S, Cantrill, H, Chan-Tram, C, Cheshier, H, Damato, K, Davies, J, Dev, S, Enloe, J, Follano, G, Gilbert, P, Johnson, J, Jones, T, Mayleben, L, Mittra, R, Moos, M, Neist, R, Oestreich, N, Quiram, P, Ramsay, R, Ryan, E, Schindeldecker, S, Snater, J, Steele, T, Selders, D, Tonsfeldt, J, Valardi, S, Fish, GE, Aguado, HA, Arceneaux, S, Arnwine, J, Bell, K, Bell, T, Boleman, B, Bradley, P, Callanan, D, Coors, L, Creighton, J, Crew, T, Cummings, K, Dock, C, Duignan, K, Fuller, D, Gray, K, Hendrix, B, Hesse, N, Jaramillo, D, Jost, B, Lash, S, Lonsdale, L, Mackens, M, Mutz, K, Potts, M, Sanchez, B, Snyder, W, Solley, W, Tarter, C, Wang, R, Williams, P, Perkins, SL, Anderson, N, Arnold, A, Blais, P, Googe, J, Higdon, TT, Hunt, C, Johnson, M, Miller, J, Moore, M, Morris, CK, Morris, C, Oelrich, S, Oliver, K, Seitz, V, Whetstone, J, Doft, BH, Bedel, J, Bergren, R, Borthwick, A, Conrad, P, Fec, A, Fulwylie, C, Ingram, W, Latham, S, Lester, G, Liu, J, Lobes, L, Lucko, NM, Mechling, H, Merlotti, L, McBroom, K, Olsen, K, Puskas, D, Rath, P, Schmucker, M, Schueckler, L, Schultz, C, Shultz, H, Steinberg, D, Vyas, A, Whale, K, Yeckel, K, Orth, DH, Arredondo, LS, Brown, S, Ciscato, BJ, Civantos, JM, Figliulo, C, Hasan, S, Kosinski, B, Muir, D, Nelson, K, Packo, K, Pollack, JS, Rezaei, K, Shelton, G, Townsend-Patrick, S, Walsh, M, Richard McDonald, H, Ansari, N, Bye, A, Fu, AD, Grout, S, Indermill, C, Johnson, RN, Michael Jumper, J, Linares, S, Lujan, BJ, Munden, A, Persons, M, Rodriguez, R, Rose, JM, Teske, B, Urias, Y, Young, S, Dreyer, RF, Daniel, H, Connaughton, M, Handelman, I, Hobbs, S, Hoerner, C, Hudson, D, Kopfer, M, Lee, M, Lemley, C, Logan, J, Ma, C, Mallet, C, Milliron, A, Peters, M, Wohlsein, H, Pearlman, JA, Andrews, M, Bartlett, M, Carlson, N, Cox, E, Equi, R, Gonzalez, M, Griffin, S, Hogue, F, Kennedy, L, Kryuchkov, L, Lopez, C, Lopez, D, Luevano, B, McKenna, E, Patel, A, Reed, B, Secor, N, Sison, IR, Tsai, T, Varghis, N, Waller, B, Wendel, R, Yebra, R, Roth, DB, Deinzer, J, Fine, H, Green, F, Green, S, Keyser, B, Leff, S, Leviton, A, Martir, A, Mosenthine, K, Muscle, S, Okoren, L, Parker, S, Prenner, J, Price, N, Rogers, D, Rosas, L, Schlosser, A, Studenko, L, Tantum, T, Wheatley, H, Trese, MT, Aaberg, T, Bezaire, D, Bridges, C, Bryant, D, Capone, A, Coleman, M, Consolo, C, Cook, C, Dulong, C, Garretson, B, Grooten, T, Hammersley, J, Hassan, T, Jessick, H, Jones, N, Kinsman, C, Krumlauf, J, Lewis, S, Locke, H, Margherio, A, Markus, D, Marsh, T, Neal, S, Noffke, A, Oh, K, Pence, C, Preston, L, Raphaelian, P, Regan, VR, Roberts, P, Ruby, A, Sarrafizadeh, R, Scherf, M, Scott, S, Sneed, S, Staples, L, Terry, B, Trese, MT, Videtich, J, Williams, G, Zajechowski, M, Joseph, DP, Blinder, K, Boyd, L, Buckley, S, Crow, M, Dinatale, A, Engelbrecht, N, Forke, B, Gabel, D, Grand, G, Grillion-Cerone, J, Holekamp, N, Kelly, C, Nobel, G, Pepple, K, Raeber, M, Kumar Rao, P, Ressel, T, Schremp, S, Sgorlon, M, Shears, S, Thomas, M, Timma, C, Vaughn, A, Walters, C, Weeks, R, Wehmeier, J, Wright, T, Berinstein, DM, Ayyad, A, Barazi, MK, Bickhart, E, Brady, T, Byank, L, Cronise, A, Denny, V, Dunn, C, Flory, M, Frantz, R, Garfinkel, RA, Gilbert, W, Lai, MM, Melamud, A, Newgen, J, Newton, S, Oliver, D, Osman, M, Sanders, R, Von Fricken, M, Dugel, P, Arenas, S, Balea, G, Bartoli, D, Bucci, J, Cornelius, JA, Dickens, S, Doherty, D, Dunlap, H, Goldenberg, D, Jamal, K, Jimenez, N, Kavanagh, N, Kunimoto, D, Martin, J, Miner, J, Mobley, S, Park, D, Quinlan, E, Sipperley, J, Slagle, C, Smith, D, Yafchak, M, Yager, R, Flaxel, CJ, Bailey, S, Francis, P, Howell, C, Hwang, T, Ira, S, Klein, M, Lauer, A, Liesegang, T, Lundquist, A, Nolte, S, Nolte, SK, Pickell, S, Pope, S, Rossi, J, Schain, M, Steinkamp, P, Toomey, MD, Vahrenwald, D, West, K, Hubbard, B, Andelman, S, Bergstrom, C, Brower, J, Cribbs, B, Curtis, L, Dobbs, J, Dubois, L, Gaultney, J, Gibbs, D, Jordan, D, Leef, D, Martin, DF, Myles, R, Olsen, T, Schwent, B, Srivastava, S, Waldron, R, Antoszyk, AN, Balasubramaniam, U, Brooks, D, Brown, J, Browning, D, Clark, L, Ennis, S, Held, S, Helms, JV, Herby, J, Karow, A, Leotaud, P, Massimino, C, McClain, D, McOwen, M, Mindel, J, Pereira, C, Pierce, R, Powers, M, Price, A, Rohrer, J, Sanders, J, Avery, RL, Avery, K, Basefsky, J, Beckner, L, Castellarin, A, Couvillion, S, Giust, J, Giust, M, Nasir, M, Pieramici, D, Rabena, M, Risard, S, See, R, Smith, J, Wan, L, Bakri, SJ, Abu-Yaghi, N, Barkmeier, A, Berg, K, Burrington, J, Edwards, A, Goddard, S, Howard, S, Iezzi, R, Lewison, D, Link, T, McCannel, CA, Overend, J, Pach, J, Ruszczyk, M, Shultz, R, Stephan, C, Vogen, D, Bradford, RH, Bergman, V, Burris, R, Butt, A, Daniels, B, Dwiggins, C, Fransen, S, Guerrero, T, Haivala, D, Harris, A, Icks, S, Kingsley, R, Redden, L, Richmond, R, Ross, B, White, K, Youngberg, M, Topping, TM, Chong, S, Ciotti, M, Cleary, T, Corey, E, Donovan, D, Frederick, A, Freese, L, Graham, M, Gud, N, Howard, T, Jones, M, Morley, M, Moses, K, Stone, J, Ty, R, Wiegand, T, Williams, L, Winder, B, Awh, CC, Amonette, M, Arrindell, E, Beck, D, Busbee, B, Dilback, A, Downs, S, Guidry, A, Gutow, G, Hardin, J, Hines, S, Hutchins, E, Lacivita, K, Lester, A, Malott, L, McCain, M, Miracle, J, Moffat, K, Palazzotta, L, Robinson, K, Sonkin, P, Travis, A, Wallace, RT, Winters, KJ, Wray, J, Harris, AE, Bunnell, M, Crooks, K, Fitzgerald, R, Javid, C, Kew, C, Kill, E, Kline, P, Kreienkamp, J, Martinez, M, Ann Moore, R, Saavedra, E, Taylor, L, Walsh, M, Wilson, L, Ciulla, TA, Coyle, E, Harrington, T, Harris, C, Hood, C, Kerr, I, Maturi, R, Moore, D, Morrow, S, Savage, J, Sink, B, Steele, T, Thukral, N, Wilburn, J, Walker, JP, Banks, J, Ciampaglia, D, Dyshanowitz, D, Frederick, J, Tom Ghuman, A, Grodin, R, Kiesel, C, Knips, E, McCue, J, Ortiz, M, Peters, C, Raskauskas, P, Schoeman, E, Sharma, A, Wing, G, Youngblood, R, Chandra, SR, Altaweel, M, Blodi, B, Burke, K, Dietzman, KA, Gottlieb, J, Knutson, G, Krolnik, D, Michael Nork, T, Olson, S, Peterson, J, Reed, S, Soderling, B, Somers, G, Stevens, T, Wealti, A, Bearelly, S, Branchaud, B, Bryant, JW, Crowell, S, Fekrat, S, Gammage, M, Harrison, C, Jones, S, McClain, N, McCuen, B, Mruthyunjaya, P, Queen, J, Sarin, N, Skalak, C, Skelly, M, Suner, I, Tomany, R, Welch, L, Park, SS, Cassidy, A, Chandra, K, Good, I, Imson, K, Kaur, S, Metzler, H, Morse, L, Redenbo, E, Salvador, M, Telander, D, Thomas, M, Wallace, C, Barr, CC, Battcher, A, Bottorff, M, Chasteen, M, Clark, K, Denning, D, Schoen, D, Schultz, A, Tempel, E, Wheeler, L, Whittington, GK, Stone, TW, Blevins, T, Buck, M, Cruz, L, Heath, W, Holcomb, D, Isernhagen, R, Kidd, T, Kitchens, J, Sears, C, Slade, E, Van Arsdall, J, Vanhoose, B, Wolfe, J, Wood, W, Zilis, J, Crooks, C, Disney, L, Liu, M, Petty, S, Sall, S, Folk, JC, Aly, T, Brotherton, A, Critser, D, Hinz, CJ, Karakas, S, Kirschner, V, Lester, C, Montague, C, Russell, S, Stockman, H, Taylor, B, Verdick, R, Walshire, J, Thompson, JT, Connell, B, Constantine, M, Davis, JL, Holsapple, G, Hunter, L, Lenane, CN, Mitchell, R, Russel, L, Sjaarda, R, Brown, DM, Benz, M, Burns, L, Carranza, JG, Fish, R, Goates, D, Hay, S, Jeffers, T, Kegley, E, Kubecka, D, McGilvra, S, Richter, B, Sneed, V, Stoever, C, Tellez, I, Wong, T, Kim, I, Andreoli, C, Barresi, L, Brett, S, Callahan, C, Capaccioli, K, Carli, W, Coppola, M, Emmanuel, N, Evans, C, Fagan, A, Grillo, M, Head, J, Kieser, T, Lee, E, Lord, U, Miretsky, E, Palitsch, K, Petrin, T, Reader, L, Reznichenko, S, Robertson, M, Smith, J, Vavvas, D, Wells, J, Cahill, C, Lloyd Clark, W, Henry, K, Johnson, D, Miller, P, Oliver, L, Spivey, R, Swinford, T, Taylor, M, Lambert, M, Chase, K, Fredrickson, D, Khawly, J, Lazarte, V, Lowd, D, Miller, P, Willis, A, Ferrone, PJ, Almonte, M, Arnott, R, Aviles, I, Carbon, S, Chitjian, M, Damore, K, Elliott, C, Fastenberg, D, Golub, B, Graham, K, Lavorna, A, Murphy, L, Palomo, A, Puglisi, C, Rhee, D, Romero, J, Rosenblatt, B, Salcedo, G, Schlameuss, M, Shakin, E, Sookhai, V, Kaiser, R, Affel, E, Brown, G, Centinaro, C, Fine, D, Fineman, M, Formoso, M, Garg, S, Grande, L, Herbert, C, Ho, A, Hsu, J, Jay, M, Lavetsky, L, Liebenbaum, E, Maguire, J, Monsonego, J, O'Connor, L, Pierce, L, Regillo, C, Rosario, M, Spirn, M, Vander, J, Walsh, J, Davidorf, FH, Barnett, A, Chang, S, Christoforidis, JB, Elliott, J, Justice, H, Letson, A, McKinney, K, Perry, J, Salerno, JA, Savage, S, Shelley, S, Singerman, LJ, Coney, J, Dubois, J, Dubois, K, Greanoff, G, Himmelman, D, Ilc, M, McNamara, E, Novak, M, Pendergast, S, Rath, S, Smith-Brewer, S, Tanner, V, Weiss, DE, Zegarra, H, Halperin, L, Aramayo, P, Dhalla, M, Fernandez, B, Fernandez, C, Lopez, J, Lopez, M, Mariano, J, Murphy, K, Sherley, C, Veksler, R, Rahhal, F, Babikian, R, Boyer, D, Hami, S, Kessinger, J, Kurokouchi, J, Mukarram, S, Pachman, S, Protacio, E, Sierra, J, Tabandeh, H, Zamboni, A, Elman, M, Belz, J, Butcher, T, Cain, T, Coffey, T, Firestone, D, Gore, N, Singletary, P, Sotirakos, P, Starr, J, Meredith, TA, Barnhart, CJ, Cantrell, D, Esquejo-Leon, R, Houghton, O, Kaur, H, Ndure, F, Glatzer, R, Joffe, L, Schindler, R, Fine, SL, Katz, M, Brightwell-Arnold, M, Glaser, R, Hall, J, Harkins, S, Huang, J, Khvatov, A, McWilliams, K, Peskin, E, Pistilli, M, Ryan, S, Schnader, A, Afrani-Sakyi, J, Balsley, B, Bennett, LS, Brooks, A, Brower-Lingsch, A, Bruce, L, Busian, D, Choong, J, Cloaninger, L, DeCroos, FC, Dubois, E, El-Dairi, M, Gach, S, Hall, K, Hawks, T, Huang, C, Heydary, C, Ho, A, Kini, S, McCall, M, Muhammad, D, Nicholson, J, Rieves, P, Shields, K, Specker, A, Stinnett, S, Subramaniam, S, Tenbrink, P, Towe, A, Welch, K, Williams, N, Winter, K, Young, E, Alexander, J, Flannagan, E, Martin, ER, Parker, C, Sepielli, K, Shannon, T, Whearry, C, Redford, M, Kopfer, MR, Ferris, FL, Dupont, J, Friedman, LM, Bressler, SB, Demets, DL, Friedlander, M, Johnson, MW, Lindblad, A, Losordo, DW & Miller, FG 2015, 'Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials', Ophthalmology, vol. 122, no. 9, pp. 1846-1853. https://doi.org/10.1016/j.ophtha.2015.05.042
Willoughby, Alex S. ; Ying, Gui Shuang ; Toth, Cynthia A. ; Maguire, Maureen G. ; Burns, Russell E. ; Grunwald, Juan E. ; Daniel, Ebenezer ; Jaffe, Glenn J. ; Williams, David F. ; Beardsley, Sara ; Bennett, Steven ; Cantrill, Herbert ; Chan-Tram, Carmen ; Cheshier, Holly ; Damato, Kathyrn ; Davies, John ; Dev, Sundeep ; Enloe, Julianne ; Follano, Gennaro ; Gilbert, Peggy ; Johnson, Jill ; Jones, Tori ; Mayleben, Lisa ; Mittra, Robert ; Moos, Martha ; Neist, Ryan ; Oestreich, Neal ; Quiram, Polly ; Ramsay, Robert ; Ryan, Edwin ; Schindeldecker, Stephanie ; Snater, John ; Steele, Trenise ; Selders, Dwight ; Tonsfeldt, Jessica ; Valardi, Shelly ; Fish, Gary Edd ; Aguado, Hank A. ; Arceneaux, Sally ; Arnwine, Jean ; Bell, Kim ; Bell, Tina ; Boleman, Bob ; Bradley, Patricia ; Callanan, David ; Coors, Lori ; Creighton, Jodi ; Crew, Timothy ; Cummings, Kimberly ; Dock, Christopher ; Duignan, Karen ; Fuller, Dwain ; Gray, Keith ; Hendrix, Betsy ; Hesse, Nicholas ; Jaramillo, Diana ; Jost, Bradley ; Lash, Sandy ; Lonsdale, Laura ; Mackens, Michael ; Mutz, Karin ; Potts, Michael ; Sanchez, Brenda ; Snyder, William ; Solley, Wayne ; Tarter, Carrie ; Wang, Robert ; Williams, Patrick ; Perkins, Stephen L. ; Anderson, Nicholas ; Arnold, Ann ; Blais, Paul ; Googe, Joseph ; Higdon, Tina T. ; Hunt, Cecile ; Johnson, Mary ; Miller, James ; Moore, Misty ; Morris, Charity K. ; Morris, Christopher ; Oelrich, Sarah ; Oliver, Kristina ; Seitz, Vicky ; Whetstone, Jerry ; Doft, Bernard H. ; Bedel, Jay ; Bergren, Robert ; Borthwick, Ann ; Conrad, Paul ; Fec, Amanda ; Fulwylie, Christina ; Ingram, Willia ; Latham, Shawnique ; Lester, Gina ; Liu, Judy ; Lobes, Louis ; Lucko, Nicole M. ; Mechling, Holly ; Merlotti, Lori ; McBroom, Keith ; Olsen, Karl ; Puskas, Danielle ; Rath, Pamela ; Schmucker, Maria ; Schueckler, Lynn ; Schultz, Christina ; Shultz, Heather ; Steinberg, David ; Vyas, Avni ; Whale, Kim ; Yeckel, Kimberly ; Orth, David H. ; Arredondo, Linda S. ; Brown, Susan ; Ciscato, Barbara J. ; Civantos, Joseph M. ; Figliulo, Celeste ; Hasan, Sohail ; Kosinski, Belinda ; Muir, Dan ; Nelson, Kiersten ; Packo, Kirk ; Pollack, John S. ; Rezaei, Kourous ; Shelton, Gina ; Townsend-Patrick, Shannya ; Walsh, Marian ; Richard McDonald, H. ; Ansari, Nina ; Bye, Amanda ; Fu, Arthur D. ; Grout, Sean ; Indermill, Chad ; Johnson, Robert N. ; Michael Jumper, J. ; Linares, Silvia ; Lujan, Brandon J. ; Munden, Ames ; Persons, Meredith ; Rodriguez, Rosa ; Rose, Jennifer M. ; Teske, Brandi ; Urias, Yesmin ; Young, Stephen ; Dreyer, Richard F. ; Daniel, Howard ; Connaughton, Michele ; Handelman, Irvin ; Hobbs, Stephen ; Hoerner, Christine ; Hudson, Dawn ; Kopfer, Marcia ; Lee, Michael ; Lemley, Craig ; Logan, Joe ; Ma, Colin ; Mallet, Christophe ; Milliron, Amanda ; Peters, Mark ; Wohlsein, Harry ; Pearlman, Joel A. ; Andrews, Margo ; Bartlett, Melissa ; Carlson, Nanette ; Cox, Emily ; Equi, Robert ; Gonzalez, Marta ; Griffin, Sophia ; Hogue, Fran ; Kennedy, Lance ; Kryuchkov, Lana ; Lopez, Carmen ; Lopez, Danny ; Luevano, Bertha ; McKenna, Erin ; Patel, Arun ; Reed, Brian ; Secor, Nyla ; Sison, Iris R. ; Tsai, Tony ; Varghis, Nina ; Waller, Brooke ; Wendel, Robert ; Yebra, Reina ; Roth, Daniel B. ; Deinzer, Jane ; Fine, Howard ; Green, Flory ; Green, Stuart ; Keyser, Bruce ; Leff, Steven ; Leviton, Amy ; Martir, Amy ; Mosenthine, Kristin ; Muscle, Starr ; Okoren, Linda ; Parker, Sandy ; Prenner, Jonathan ; Price, Nancy ; Rogers, Deana ; Rosas, Linda ; Schlosser, Alex ; Studenko, Loretta ; Tantum, Thea ; Wheatley, Harold ; Trese, Michael T. ; Aaberg, Thomas ; Bezaire, Denis ; Bridges, Craig ; Bryant, Doug ; Capone, Antonio ; Coleman, Michelle ; Consolo, Christina ; Cook, Cindy ; Dulong, Candice ; Garretson, Bruce ; Grooten, Tracy ; Hammersley, Julie ; Hassan, Tarek ; Jessick, Heather ; Jones, Nanette ; Kinsman, Crystal ; Krumlauf, Jennifer ; Lewis, Sandy ; Locke, Heather ; Margherio, Alan ; Markus, Debra ; Marsh, Tanya ; Neal, Serena ; Noffke, Amy ; Oh, Kean ; Pence, Clarence ; Preston, Lisa ; Raphaelian, Paul ; Regan, Virginia R. ; Roberts, Peter ; Ruby, Alan ; Sarrafizadeh, Ramin ; Scherf, Marissa ; Scott, Sarita ; Sneed, Scott ; Staples, Lisa ; Terry, Brad ; Trese, Matthew T. ; Videtich, Joan ; Williams, George ; Zajechowski, Mary ; Joseph, Daniel P. ; Blinder, Kevin ; Boyd, Lynda ; Buckley, Sarah ; Crow, Meaghan ; Dinatale, Amanda ; Engelbrecht, Nicholas ; Forke, Bridget ; Gabel, Dana ; Grand, Gilbert ; Grillion-Cerone, Jennifer ; Holekamp, Nancy ; Kelly, Charlotte ; Nobel, Ginny ; Pepple, Kelly ; Raeber, Matt ; Kumar Rao, P. ; Ressel, Tammy ; Schremp, Steven ; Sgorlon, Merrilee ; Shears, Shantia ; Thomas, Matthew ; Timma, Cathy ; Vaughn, Annette ; Walters, Carolyn ; Weeks, Rhonda ; Wehmeier, Jarrod ; Wright, Tim ; Berinstein, Daniel M. ; Ayyad, Aida ; Barazi, Mohammed K. ; Bickhart, Erica ; Brady, Tracey ; Byank, Lisa ; Cronise, Alysia ; Denny, Vanessa ; Dunn, Courtney ; Flory, Michael ; Frantz, Robert ; Garfinkel, Richard A. ; Gilbert, William ; Lai, Michael M. ; Melamud, Alexander ; Newgen, Janine ; Newton, Shamekia ; Oliver, Debbie ; Osman, Michael ; Sanders, Reginald ; Von Fricken, Manfred ; Dugel, Pravin ; Arenas, Sandra ; Balea, Gabe ; Bartoli, Dayna ; Bucci, John ; Cornelius, Jennifer A. ; Dickens, Scheleen ; Doherty, Don ; Dunlap, Heather ; Goldenberg, David ; Jamal, Karim ; Jimenez, Norma ; Kavanagh, Nicole ; Kunimoto, Derek ; Martin, John ; Miner, Jessica ; Mobley, Sarah ; Park, Donald ; Quinlan, Edward ; Sipperley, Jack ; Slagle, Carol ; Smith, Danielle ; Yafchak, Miguelina ; Yager, Rohana ; Flaxel, Christina J. ; Bailey, Steven ; Francis, Peter ; Howell, Chris ; Hwang, Thomas ; Ira, Shirley ; Klein, Michael ; Lauer, Andreas ; Liesegang, Teresa ; Lundquist, Ann ; Nolte, Sarah ; Nolte, Susan K. ; Pickell, Scott ; Pope, Susan ; Rossi, Joseph ; Schain, Mitchell ; Steinkamp, Peter ; Toomey, Maureen D. ; Vahrenwald, Debora ; West, Kelly ; Hubbard, Baker ; Andelman, Stacey ; Bergstrom, Chris ; Brower, Judy ; Cribbs, Blaine ; Curtis, Linda ; Dobbs, Jannah ; Dubois, Lindreth ; Gaultney, Jessica ; Gibbs, Deborah ; Jordan, Debora ; Leef, Donna ; Martin, Daniel F. ; Myles, Robert ; Olsen, Timothy ; Schwent, Bryan ; Srivastava, Sunil ; Waldron, Rhonda ; Antoszyk, Andrew N. ; Balasubramaniam, Uma ; Brooks, Danielle ; Brown, Justin ; Browning, David ; Clark, Loraine ; Ennis, Sarah ; Held, Susannah ; Helms, Jennifer V. ; Herby, Jenna ; Karow, Angie ; Leotaud, Pearl ; Massimino, Caterina ; McClain, Donna ; McOwen, Michael ; Mindel, Jennifer ; Pereira, Candace ; Pierce, Rachel ; Powers, Michele ; Price, Angela ; Rohrer, Jason ; Sanders, Jason ; Avery, Robert L. ; Avery, Kelly ; Basefsky, Jessica ; Beckner, Liz ; Castellarin, Alessandro ; Couvillion, Stephen ; Giust, Jack ; Giust, Matthew ; Nasir, Maan ; Pieramici, Dante ; Rabena, Melvin ; Risard, Sarah ; See, Robert ; Smith, Jerry ; Wan, Lisha ; Bakri, Sophie J. ; Abu-Yaghi, Nakhleh ; Barkmeier, Andrew ; Berg, Karin ; Burrington, Jean ; Edwards, Albert ; Goddard, Shannon ; Howard, Shannon ; Iezzi, Raymond ; Lewison, Denise ; Link, Thomas ; McCannel, Colin A. ; Overend, Joan ; Pach, John ; Ruszczyk, Margaret ; Shultz, Ryan ; Stephan, Cindy ; Vogen, Diane ; Bradford, Reagan H. ; Bergman, Vanessa ; Burris, Russ ; Butt, Amanda ; Daniels, Beth ; Dwiggins, Connie ; Fransen, Stephen ; Guerrero, Tiffany ; Haivala, Darin ; Harris, Amy ; Icks, Sonny ; Kingsley, Ronald ; Redden, Lena ; Richmond, Rob ; Ross, Brittany ; White, Kammerin ; Youngberg, Misty ; Topping, Trexler M. ; Chong, Sandy ; Ciotti, Mary ; Cleary, Tina ; Corey, Emily ; Donovan, Dennis ; Frederick, Albert ; Freese, Lesley ; Graham, Margaret ; Gud, Natalya ; Howard, Taneika ; Jones, Mike ; Morley, Michael ; Moses, Katie ; Stone, Jen ; Ty, Robin ; Wiegand, Torsten ; Williams, Lindsey ; Winder, Beth ; Awh, Carl C. ; Amonette, Michelle ; Arrindell, Everton ; Beck, Dena ; Busbee, Brandon ; Dilback, Amy ; Downs, Sara ; Guidry, Allison ; Gutow, Gary ; Hardin, Jackey ; Hines, Sarah ; Hutchins, Emily ; Lacivita, Kim ; Lester, Ashley ; Malott, Larry ; McCain, Maryann ; Miracle, Jayme ; Moffat, Kenneth ; Palazzotta, Lacy ; Robinson, Kelly ; Sonkin, Peter ; Travis, Alecia ; Wallace, Roy Trent ; Winters, Kelly J. ; Wray, Julia ; Harris, April E. ; Bunnell, Mari ; Crooks, Katrina ; Fitzgerald, Rebecca ; Javid, Cameron ; Kew, Corin ; Kill, Erica ; Kline, Patricia ; Kreienkamp, Janet ; Martinez, Maricruz ; Ann Moore, Roy ; Saavedra, Egbert ; Taylor, Luanne ; Walsh, Mark ; Wilson, Larry ; Ciulla, Thomas A. ; Coyle, Ellen ; Harrington, Tonya ; Harris, Charlotte ; Hood, Cindi ; Kerr, Ingrid ; Maturi, Raj ; Moore, Dawn ; Morrow, Stephanie ; Savage, Jennifer ; Sink, Bethany ; Steele, Tom ; Thukral, Neelam ; Wilburn, Janet ; Walker, Joseph P. ; Banks, Jennifer ; Ciampaglia, Debbie ; Dyshanowitz, Danielle ; Frederick, Jennifer ; Tom Ghuman, A. ; Grodin, Richard ; Kiesel, Cheryl ; Knips, Eileen ; McCue, Jonathan ; Ortiz, Maria ; Peters, Crystal ; Raskauskas, Paul ; Schoeman, Etienne ; Sharma, Ashish ; Wing, Glenn ; Youngblood, Rebecca ; Chandra, Suresh R. ; Altaweel, Michael ; Blodi, Barbara ; Burke, Kathryn ; Dietzman, Kristine A. ; Gottlieb, Justin ; Knutson, Gene ; Krolnik, Denise ; Michael Nork, T. ; Olson, Shelly ; Peterson, John ; Reed, Sandra ; Soderling, Barbara ; Somers, Guy ; Stevens, Thomas ; Wealti, Angela ; Bearelly, Srilaxmi ; Branchaud, Brenda ; Bryant, Joyce W. ; Crowell, Sara ; Fekrat, Sharon ; Gammage, Merritt ; Harrison, Cheala ; Jones, Sarah ; McClain, Noreen ; McCuen, Brooks ; Mruthyunjaya, Prithvi ; Queen, Jeanne ; Sarin, Neeru ; Skalak, Cindy ; Skelly, Marriner ; Suner, Ivan ; Tomany, Ronnie ; Welch, Lauren ; Park, Susanna S. ; Cassidy, Allison ; Chandra, Karishma ; Good, Idalew ; Imson, Katrina ; Kaur, Sashi ; Metzler, Helen ; Morse, Lawrence ; Redenbo, Ellen ; Salvador, Marisa ; Telander, David ; Thomas, Mark ; Wallace, Cindy ; Barr, Charles C. ; Battcher, Amanda ; Bottorff, Michelle ; Chasteen, Mary ; Clark, Kelly ; Denning, Diane ; Schoen, Debra ; Schultz, Amy ; Tempel, Evie ; Wheeler, Lisa ; Whittington, Greg K. ; Stone, Thomas W. ; Blevins, Todd ; Buck, Michelle ; Cruz, Lynn ; Heath, Wanda ; Holcomb, Diana ; Isernhagen, Rick ; Kidd, Terri ; Kitchens, John ; Sears, Cathy ; Slade, Ed ; Van Arsdall, Jeanne ; Vanhoose, Brenda ; Wolfe, Jenny ; Wood, William ; Zilis, John ; Crooks, Carol ; Disney, Larry ; Liu, Mimi ; Petty, Stephen ; Sall, Sandra ; Folk, James C. ; Aly, Tracy ; Brotherton, Abby ; Critser, Douglas ; Hinz, Connie J. ; Karakas, Stefani ; Kirschner, Valerie ; Lester, Cheyanne ; Montague, Cindy ; Russell, Stephen ; Stockman, Heather ; Taylor, Barbara ; Verdick, Randy ; Walshire, Jean ; Thompson, John T. ; Connell, Barbara ; Constantine, Maryanth ; Davis, John L. ; Holsapple, Gwen ; Hunter, Lisa ; Lenane, C. Nicki ; Mitchell, Robin ; Russel, Leslie ; Sjaarda, Raymond ; Brown, David M. ; Benz, Matthew ; Burns, Llewellyn ; Carranza, Jolene G. ; Fish, Richard ; Goates, Debra ; Hay, Shayla ; Jeffers, Theresa ; Kegley, Eric ; Kubecka, Dallas ; McGilvra, Stacy ; Richter, Beau ; Sneed, Veronica ; Stoever, Cary ; Tellez, Isabell ; Wong, Tien ; Kim, Ivana ; Andreoli, Christopher ; Barresi, Leslie ; Brett, Sarah ; Callahan, Charlene ; Capaccioli, Karen ; Carli, William ; Coppola, Matthew ; Emmanuel, Nicholas ; Evans, Claudia ; Fagan, Anna ; Grillo, Marcia ; Head, John ; Kieser, Troy ; Lee, Elaine ; Lord, Ursula ; Miretsky, Edward ; Palitsch, Kate ; Petrin, Todd ; Reader, Liz ; Reznichenko, Svetlana ; Robertson, Mary ; Smith, Justin ; Vavvas, Demetrios ; Wells, John ; Cahill, Cassie ; Lloyd Clark, W. ; Henry, Kayla ; Johnson, David ; Miller, Peggy ; Oliver, Ladetrick ; Spivey, Robbin ; Swinford, Tiffany ; Taylor, Mallie ; Lambert, Michael ; Chase, Kris ; Fredrickson, Debbie ; Khawly, Joseph ; Lazarte, Valerie ; Lowd, Donald ; Miller, Pam ; Willis, Arthur ; Ferrone, Philip J. ; Almonte, Miguel ; Arnott, Rachel ; Aviles, Ingrid ; Carbon, Sheri ; Chitjian, Michael ; Damore, Kristen ; Elliott, Christin ; Fastenberg, David ; Golub, Barry ; Graham, Kenneth ; Lavorna, Annmarie ; Murphy, Laura ; Palomo, Amanda ; Puglisi, Christina ; Rhee, David ; Romero, Juan ; Rosenblatt, Brett ; Salcedo, Glenda ; Schlameuss, Marianne ; Shakin, Eric ; Sookhai, Vasanti ; Kaiser, Richard ; Affel, Elizabeth ; Brown, Gary ; Centinaro, Christina ; Fine, Deborah ; Fineman, Mitchell ; Formoso, Michele ; Garg, Sunir ; Grande, Lisa ; Herbert, Carolyn ; Ho, Allen ; Hsu, Jason ; Jay, Maryann ; Lavetsky, Lisa ; Liebenbaum, Elaine ; Maguire, Joseph ; Monsonego, Julia ; O'Connor, Lucia ; Pierce, Lisa ; Regillo, Carl ; Rosario, Maria ; Spirn, Marc ; Vander, James ; Walsh, Jennifer ; Davidorf, Frederick H. ; Barnett, Amanda ; Chang, Susie ; Christoforidis, John B ; Elliott, Joy ; Justice, Heather ; Letson, Alan ; McKinney, Kathryne ; Perry, Jeri ; Salerno, Jill A. ; Savage, Scott ; Shelley, Stephen ; Singerman, Lawrence J. ; Coney, Joseph ; Dubois, John ; Dubois, Kimberly ; Greanoff, Gregg ; Himmelman, Dianne ; Ilc, Mary ; McNamara, Elizabeth ; Novak, Michael ; Pendergast, Scott ; Rath, Susan ; Smith-Brewer, Sheila ; Tanner, Vivian ; Weiss, Diane E. ; Zegarra, Hernando ; Halperin, Lawrence ; Aramayo, Patricia ; Dhalla, Mandeep ; Fernandez, Brian ; Fernandez, Cindy ; Lopez, Jaclyn ; Lopez, Monica ; Mariano, Jamie ; Murphy, Kellie ; Sherley, Clifford ; Veksler, Rita ; Rahhal, Firas ; Babikian, Razmig ; Boyer, David ; Hami, Sepideh ; Kessinger, Jeff ; Kurokouchi, Janet ; Mukarram, Saba ; Pachman, Sarah ; Protacio, Eric ; Sierra, Julio ; Tabandeh, Homayoun ; Zamboni, Adam ; Elman, Michael ; Belz, Jennifer ; Butcher, Tammy ; Cain, Theresa ; Coffey, Teresa ; Firestone, Dena ; Gore, Nancy ; Singletary, Pamela ; Sotirakos, Peter ; Starr, Joann ; Meredith, Travis A. ; Barnhart, Cassandra J. ; Cantrell, Debra ; Esquejo-Leon, Ronalyn ; Houghton, Odette ; Kaur, Harpreet ; Ndure, Fatoumatta ; Glatzer, Ronald ; Joffe, Leonard ; Schindler, Reid ; Fine, Stuart L. ; Katz, Marilyn ; Brightwell-Arnold, Mary ; Glaser, Ruchira ; Hall, Judith ; Harkins, Sandra ; Huang, Jiayan ; Khvatov, Alexander ; McWilliams, Kathy ; Peskin, Ellen ; Pistilli, Maxwell ; Ryan, Susan ; Schnader, Allison ; Afrani-Sakyi, Jennifer ; Balsley, Brannon ; Bennett, Linda S. ; Brooks, Adam ; Brower-Lingsch, Adrienne ; Bruce, Lori ; Busian, Dee ; Choong, John ; Cloaninger, Lindsey ; DeCroos, Francis Char ; Dubois, Emily ; El-Dairi, Mays ; Gach, Sarah ; Hall, Katelyn ; Hawks, Terry ; Huang, Chengchenh ; Heydary, Cindy ; Ho, Alexander ; Kini, Shashi ; McCall, Michelle ; Muhammad, Daaimah ; Nicholson, Jayne ; Rieves, Pamela ; Shields, Kelly ; Specker, Adam ; Stinnett, Sandra ; Subramaniam, Sujatha ; Tenbrink, Patrick ; Towe, Aaron ; Welch, Kimberly ; Williams, Natasha ; Winter, Katrina ; Young, Ellen ; Alexander, Judith ; Flannagan, Elisabeth ; Martin, E. Revell ; Parker, Candace ; Sepielli, Krista ; Shannon, Tom ; Whearry, Claressa ; Redford, Maryann ; Kopfer, Marcia R. ; Ferris, Frederick L. ; Dupont, Joan ; Friedman, Lawrence M. ; Bressler, Susan B. ; Demets, David L. ; Friedlander, Martin ; Johnson, Mark W. ; Lindblad, Anne ; Losordo, Douglas W. ; Miller, Franklin G. / Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials. In: Ophthalmology. 2015 ; Vol. 122, No. 9. pp. 1846-1853.
@article{76a2c0fa225544a18257536c2c054f8a,
title = "Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials",
abstract = "Purpose To evaluate the association of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA), and scar in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Design Prospective cohort study within a randomized clinical trial. Participants The 1185 CATT participants. Methods Masked readers graded scar and GA on fundus photography and fluorescein angiography and graded SHRM on time-domain and spectral-domain (SD) optical coherence tomography (OCT) throughout 104 weeks. Measurements of SHRM height and width in the fovea, within the center 1 mm2, or outside the center 1mm2 were obtained on SD OCT images at 56 (n = 76) and 104 (n = 66) weeks. Main Outcome Measures Presence of SHRM, as well as location and size, and associations with VA, scar, and GA. Results Among CATT participants, the percentage with SHRM at enrollment was 77{\%}, decreasing to 68{\%} at 4 weeks after treatment and to 54{\%} at 104 weeks. At 104 weeks, scar was present more often in eyes with persistent SHRM than in eyes with SHRM that resolved (64{\%} vs. 31{\%}; P <0.0001). Among eyes with detailed evaluation of SHRM at weeks 56 (n = 76) and 104 (n = 66), mean VA letter score was 73.5 (standard error [SE], 2.8), 73.1 (SE, 3.4), 65.3 (SE, 3.5), and 63.9 (SE, 3.7) when SHRM was absent, present outside the central 1 mm2, present within the central 1 mm2 but not the foveal center, or present at the foveal center (P = 0.02), respectively. When SHRM was present, the median maximum height under the fovea, within the central 1 mm2 including the fovea and anywhere within the scan, was 86 μm, 120 μm, and 122 μm, respectively. Visual acuity was decreased with greater SHRM height and width (P <0.05). Conclusions In eyes with neovascular age-related macular degeneration (AMD), SHRM is common and often persists after anti-vascular endothelial growth factor treatment. At 2 years, eyes with scar were more likely to have SHRM than other eyes. Greater SHRM dimensions were associated with worse VA. In eyes with neovascular AMD, SHRM is an important morphologic biomarker.",
author = "Willoughby, {Alex S.} and Ying, {Gui Shuang} and Toth, {Cynthia A.} and Maguire, {Maureen G.} and Burns, {Russell E.} and Grunwald, {Juan E.} and Ebenezer Daniel and Jaffe, {Glenn J.} and Williams, {David F.} and Sara Beardsley and Steven Bennett and Herbert Cantrill and Carmen Chan-Tram and Holly Cheshier and Kathyrn Damato and John Davies and Sundeep Dev and Julianne Enloe and Gennaro Follano and Peggy Gilbert and Jill Johnson and Tori Jones and Lisa Mayleben and Robert Mittra and Martha Moos and Ryan Neist and Neal Oestreich and Polly Quiram and Robert Ramsay and Edwin Ryan and Stephanie Schindeldecker and John Snater and Trenise Steele and Dwight Selders and Jessica Tonsfeldt and Shelly Valardi and Fish, {Gary Edd} and Aguado, {Hank A.} and Sally Arceneaux and Jean Arnwine and Kim Bell and Tina Bell and Bob Boleman and Patricia Bradley and David Callanan and Lori Coors and Jodi Creighton and Timothy Crew and Kimberly Cummings and Christopher Dock and Karen Duignan and Dwain Fuller and Keith Gray and Betsy Hendrix and Nicholas Hesse and Diana Jaramillo and Bradley Jost and Sandy Lash and Laura Lonsdale and Michael Mackens and Karin Mutz and Michael Potts and Brenda Sanchez and William Snyder and Wayne Solley and Carrie Tarter and Robert Wang and Patrick Williams and Perkins, {Stephen L.} and Nicholas Anderson and Ann Arnold and Paul Blais and Joseph Googe and Higdon, {Tina T.} and Cecile Hunt and Mary Johnson and James Miller and Misty Moore and Morris, {Charity K.} and Christopher Morris and Sarah Oelrich and Kristina Oliver and Vicky Seitz and Jerry Whetstone and Doft, {Bernard H.} and Jay Bedel and Robert Bergren and Ann Borthwick and Paul Conrad and Amanda Fec and Christina Fulwylie and Willia Ingram and Shawnique Latham and Gina Lester and Judy Liu and Louis Lobes and Lucko, {Nicole M.} and Holly Mechling and Lori Merlotti and Keith McBroom and Karl Olsen and Danielle Puskas and Pamela Rath and Maria Schmucker and Lynn Schueckler and Christina Schultz and Heather Shultz and David Steinberg and Avni Vyas and Kim Whale and Kimberly Yeckel and Orth, {David H.} and Arredondo, {Linda S.} and Susan Brown and Ciscato, {Barbara J.} and Civantos, {Joseph M.} and Celeste Figliulo and Sohail Hasan and Belinda Kosinski and Dan Muir and Kiersten Nelson and Kirk Packo and Pollack, {John S.} and Kourous Rezaei and Gina Shelton and Shannya Townsend-Patrick and Marian Walsh and {Richard McDonald}, H. and Nina Ansari and Amanda Bye and Fu, {Arthur D.} and Sean Grout and Chad Indermill and Johnson, {Robert N.} and {Michael Jumper}, J. and Silvia Linares and Lujan, {Brandon J.} and Ames Munden and Meredith Persons and Rosa Rodriguez and Rose, {Jennifer M.} and Brandi Teske and Yesmin Urias and Stephen Young and Dreyer, {Richard F.} and Howard Daniel and Michele Connaughton and Irvin Handelman and Stephen Hobbs and Christine Hoerner and Dawn Hudson and Marcia Kopfer and Michael Lee and Craig Lemley and Joe Logan and Colin Ma and Christophe Mallet and Amanda Milliron and Mark Peters and Harry Wohlsein and Pearlman, {Joel A.} and Margo Andrews and Melissa Bartlett and Nanette Carlson and Emily Cox and Robert Equi and Marta Gonzalez and Sophia Griffin and Fran Hogue and Lance Kennedy and Lana Kryuchkov and Carmen Lopez and Danny Lopez and Bertha Luevano and Erin McKenna and Arun Patel and Brian Reed and Nyla Secor and Sison, {Iris R.} and Tony Tsai and Nina Varghis and Brooke Waller and Robert Wendel and Reina Yebra and Roth, {Daniel B.} and Jane Deinzer and Howard Fine and Flory Green and Stuart Green and Bruce Keyser and Steven Leff and Amy Leviton and Amy Martir and Kristin Mosenthine and Starr Muscle and Linda Okoren and Sandy Parker and Jonathan Prenner and Nancy Price and Deana Rogers and Linda Rosas and Alex Schlosser and Loretta Studenko and Thea Tantum and Harold Wheatley and Trese, {Michael T.} and Thomas Aaberg and Denis Bezaire and Craig Bridges and Doug Bryant and Antonio Capone and Michelle Coleman and Christina Consolo and Cindy Cook and Candice Dulong and Bruce Garretson and Tracy Grooten and Julie Hammersley and Tarek Hassan and Heather Jessick and Nanette Jones and Crystal Kinsman and Jennifer Krumlauf and Sandy Lewis and Heather Locke and Alan Margherio and Debra Markus and Tanya Marsh and Serena Neal and Amy Noffke and Kean Oh and Clarence Pence and Lisa Preston and Paul Raphaelian and Regan, {Virginia R.} and Peter Roberts and Alan Ruby and Ramin Sarrafizadeh and Marissa Scherf and Sarita Scott and Scott Sneed and Lisa Staples and Brad Terry and Trese, {Matthew T.} and Joan Videtich and George Williams and Mary Zajechowski and Joseph, {Daniel P.} and Kevin Blinder and Lynda Boyd and Sarah Buckley and Meaghan Crow and Amanda Dinatale and Nicholas Engelbrecht and Bridget Forke and Dana Gabel and Gilbert Grand and Jennifer Grillion-Cerone and Nancy Holekamp and Charlotte Kelly and Ginny Nobel and Kelly Pepple and Matt Raeber and {Kumar Rao}, P. and Tammy Ressel and Steven Schremp and Merrilee Sgorlon and Shantia Shears and Matthew Thomas and Cathy Timma and Annette Vaughn and Carolyn Walters and Rhonda Weeks and Jarrod Wehmeier and Tim Wright and Berinstein, {Daniel M.} and Aida Ayyad and Barazi, {Mohammed K.} and Erica Bickhart and Tracey Brady and Lisa Byank and Alysia Cronise and Vanessa Denny and Courtney Dunn and Michael Flory and Robert Frantz and Garfinkel, {Richard A.} and William Gilbert and Lai, {Michael M.} and Alexander Melamud and Janine Newgen and Shamekia Newton and Debbie Oliver and Michael Osman and Reginald Sanders and {Von Fricken}, Manfred and Pravin Dugel and Sandra Arenas and Gabe Balea and Dayna Bartoli and John Bucci and Cornelius, {Jennifer A.} and Scheleen Dickens and Don Doherty and Heather Dunlap and David Goldenberg and Karim Jamal and Norma Jimenez and Nicole Kavanagh and Derek Kunimoto and John Martin and Jessica Miner and Sarah Mobley and Donald Park and Edward Quinlan and Jack Sipperley and Carol Slagle and Danielle Smith and Miguelina Yafchak and Rohana Yager and Flaxel, {Christina J.} and Steven Bailey and Peter Francis and Chris Howell and Thomas Hwang and Shirley Ira and Michael Klein and Andreas Lauer and Teresa Liesegang and Ann Lundquist and Sarah Nolte and Nolte, {Susan K.} and Scott Pickell and Susan Pope and Joseph Rossi and Mitchell Schain and Peter Steinkamp and Toomey, {Maureen D.} and Debora Vahrenwald and Kelly West and Baker Hubbard and Stacey Andelman and Chris Bergstrom and Judy Brower and Blaine Cribbs and Linda Curtis and Jannah Dobbs and Lindreth Dubois and Jessica Gaultney and Deborah Gibbs and Debora Jordan and Donna Leef and Martin, {Daniel F.} and Robert Myles and Timothy Olsen and Bryan Schwent and Sunil Srivastava and Rhonda Waldron and Antoszyk, {Andrew N.} and Uma Balasubramaniam and Danielle Brooks and Justin Brown and David Browning and Loraine Clark and Sarah Ennis and Susannah Held and Helms, {Jennifer V.} and Jenna Herby and Angie Karow and Pearl Leotaud and Caterina Massimino and Donna McClain and Michael McOwen and Jennifer Mindel and Candace Pereira and Rachel Pierce and Michele Powers and Angela Price and Jason Rohrer and Jason Sanders and Avery, {Robert L.} and Kelly Avery and Jessica Basefsky and Liz Beckner and Alessandro Castellarin and Stephen Couvillion and Jack Giust and Matthew Giust and Maan Nasir and Dante Pieramici and Melvin Rabena and Sarah Risard and Robert See and Jerry Smith and Lisha Wan and Bakri, {Sophie J.} and Nakhleh Abu-Yaghi and Andrew Barkmeier and Karin Berg and Jean Burrington and Albert Edwards and Shannon Goddard and Shannon Howard and Raymond Iezzi and Denise Lewison and Thomas Link and McCannel, {Colin A.} and Joan Overend and John Pach and Margaret Ruszczyk and Ryan Shultz and Cindy Stephan and Diane Vogen and Bradford, {Reagan H.} and Vanessa Bergman and Russ Burris and Amanda Butt and Beth Daniels and Connie Dwiggins and Stephen Fransen and Tiffany Guerrero and Darin Haivala and Amy Harris and Sonny Icks and Ronald Kingsley and Lena Redden and Rob Richmond and Brittany Ross and Kammerin White and Misty Youngberg and Topping, {Trexler M.} and Sandy Chong and Mary Ciotti and Tina Cleary and Emily Corey and Dennis Donovan and Albert Frederick and Lesley Freese and Margaret Graham and Natalya Gud and Taneika Howard and Mike Jones and Michael Morley and Katie Moses and Jen Stone and Robin Ty and Torsten Wiegand and Lindsey Williams and Beth Winder and Awh, {Carl C.} and Michelle Amonette and Everton Arrindell and Dena Beck and Brandon Busbee and Amy Dilback and Sara Downs and Allison Guidry and Gary Gutow and Jackey Hardin and Sarah Hines and Emily Hutchins and Kim Lacivita and Ashley Lester and Larry Malott and Maryann McCain and Jayme Miracle and Kenneth Moffat and Lacy Palazzotta and Kelly Robinson and Peter Sonkin and Alecia Travis and Wallace, {Roy Trent} and Winters, {Kelly J.} and Julia Wray and Harris, {April E.} and Mari Bunnell and Katrina Crooks and Rebecca Fitzgerald and Cameron Javid and Corin Kew and Erica Kill and Patricia Kline and Janet Kreienkamp and Maricruz Martinez and {Ann Moore}, Roy and Egbert Saavedra and Luanne Taylor and Mark Walsh and Larry Wilson and Ciulla, {Thomas A.} and Ellen Coyle and Tonya Harrington and Charlotte Harris and Cindi Hood and Ingrid Kerr and Raj Maturi and Dawn Moore and Stephanie Morrow and Jennifer Savage and Bethany Sink and Tom Steele and Neelam Thukral and Janet Wilburn and Walker, {Joseph P.} and Jennifer Banks and Debbie Ciampaglia and Danielle Dyshanowitz and Jennifer Frederick and {Tom Ghuman}, A. and Richard Grodin and Cheryl Kiesel and Eileen Knips and Jonathan McCue and Maria Ortiz and Crystal Peters and Paul Raskauskas and Etienne Schoeman and Ashish Sharma and Glenn Wing and Rebecca Youngblood and Chandra, {Suresh R.} and Michael Altaweel and Barbara Blodi and Kathryn Burke and Dietzman, {Kristine A.} and Justin Gottlieb and Gene Knutson and Denise Krolnik and {Michael Nork}, T. and Shelly Olson and John Peterson and Sandra Reed and Barbara Soderling and Guy Somers and Thomas Stevens and Angela Wealti and Srilaxmi Bearelly and Brenda Branchaud and Bryant, {Joyce W.} and Sara Crowell and Sharon Fekrat and Merritt Gammage and Cheala Harrison and Sarah Jones and Noreen McClain and Brooks McCuen and Prithvi Mruthyunjaya and Jeanne Queen and Neeru Sarin and Cindy Skalak and Marriner Skelly and Ivan Suner and Ronnie Tomany and Lauren Welch and Park, {Susanna S.} and Allison Cassidy and Karishma Chandra and Idalew Good and Katrina Imson and Sashi Kaur and Helen Metzler and Lawrence Morse and Ellen Redenbo and Marisa Salvador and David Telander and Mark Thomas and Cindy Wallace and Barr, {Charles C.} and Amanda Battcher and Michelle Bottorff and Mary Chasteen and Kelly Clark and Diane Denning and Debra Schoen and Amy Schultz and Evie Tempel and Lisa Wheeler and Whittington, {Greg K.} and Stone, {Thomas W.} and Todd Blevins and Michelle Buck and Lynn Cruz and Wanda Heath and Diana Holcomb and Rick Isernhagen and Terri Kidd and John Kitchens and Cathy Sears and Ed Slade and {Van Arsdall}, Jeanne and Brenda Vanhoose and Jenny Wolfe and William Wood and John Zilis and Carol Crooks and Larry Disney and Mimi Liu and Stephen Petty and Sandra Sall and Folk, {James C.} and Tracy Aly and Abby Brotherton and Douglas Critser and Hinz, {Connie J.} and Stefani Karakas and Valerie Kirschner and Cheyanne Lester and Cindy Montague and Stephen Russell and Heather Stockman and Barbara Taylor and Randy Verdick and Jean Walshire and Thompson, {John T.} and Barbara Connell and Maryanth Constantine and Davis, {John L.} and Gwen Holsapple and Lisa Hunter and Lenane, {C. Nicki} and Robin Mitchell and Leslie Russel and Raymond Sjaarda and Brown, {David M.} and Matthew Benz and Llewellyn Burns and Carranza, {Jolene G.} and Richard Fish and Debra Goates and Shayla Hay and Theresa Jeffers and Eric Kegley and Dallas Kubecka and Stacy McGilvra and Beau Richter and Veronica Sneed and Cary Stoever and Isabell Tellez and Tien Wong and Ivana Kim and Christopher Andreoli and Leslie Barresi and Sarah Brett and Charlene Callahan and Karen Capaccioli and William Carli and Matthew Coppola and Nicholas Emmanuel and Claudia Evans and Anna Fagan and Marcia Grillo and John Head and Troy Kieser and Elaine Lee and Ursula Lord and Edward Miretsky and Kate Palitsch and Todd Petrin and Liz Reader and Svetlana Reznichenko and Mary Robertson and Justin Smith and Demetrios Vavvas and John Wells and Cassie Cahill and {Lloyd Clark}, W. and Kayla Henry and David Johnson and Peggy Miller and Ladetrick Oliver and Robbin Spivey and Tiffany Swinford and Mallie Taylor and Michael Lambert and Kris Chase and Debbie Fredrickson and Joseph Khawly and Valerie Lazarte and Donald Lowd and Pam Miller and Arthur Willis and Ferrone, {Philip J.} and Miguel Almonte and Rachel Arnott and Ingrid Aviles and Sheri Carbon and Michael Chitjian and Kristen Damore and Christin Elliott and David Fastenberg and Barry Golub and Kenneth Graham and Annmarie Lavorna and Laura Murphy and Amanda Palomo and Christina Puglisi and David Rhee and Juan Romero and Brett Rosenblatt and Glenda Salcedo and Marianne Schlameuss and Eric Shakin and Vasanti Sookhai and Richard Kaiser and Elizabeth Affel and Gary Brown and Christina Centinaro and Deborah Fine and Mitchell Fineman and Michele Formoso and Sunir Garg and Lisa Grande and Carolyn Herbert and Allen Ho and Jason Hsu and Maryann Jay and Lisa Lavetsky and Elaine Liebenbaum and Joseph Maguire and Julia Monsonego and Lucia O'Connor and Lisa Pierce and Carl Regillo and Maria Rosario and Marc Spirn and James Vander and Jennifer Walsh and Davidorf, {Frederick H.} and Amanda Barnett and Susie Chang and Christoforidis, {John B} and Joy Elliott and Heather Justice and Alan Letson and Kathryne McKinney and Jeri Perry and Salerno, {Jill A.} and Scott Savage and Stephen Shelley and Singerman, {Lawrence J.} and Joseph Coney and John Dubois and Kimberly Dubois and Gregg Greanoff and Dianne Himmelman and Mary Ilc and Elizabeth McNamara and Michael Novak and Scott Pendergast and Susan Rath and Sheila Smith-Brewer and Vivian Tanner and Weiss, {Diane E.} and Hernando Zegarra and Lawrence Halperin and Patricia Aramayo and Mandeep Dhalla and Brian Fernandez and Cindy Fernandez and Jaclyn Lopez and Monica Lopez and Jamie Mariano and Kellie Murphy and Clifford Sherley and Rita Veksler and Firas Rahhal and Razmig Babikian and David Boyer and Sepideh Hami and Jeff Kessinger and Janet Kurokouchi and Saba Mukarram and Sarah Pachman and Eric Protacio and Julio Sierra and Homayoun Tabandeh and Adam Zamboni and Michael Elman and Jennifer Belz and Tammy Butcher and Theresa Cain and Teresa Coffey and Dena Firestone and Nancy Gore and Pamela Singletary and Peter Sotirakos and Joann Starr and Meredith, {Travis A.} and Barnhart, {Cassandra J.} and Debra Cantrell and Ronalyn Esquejo-Leon and Odette Houghton and Harpreet Kaur and Fatoumatta Ndure and Ronald Glatzer and Leonard Joffe and Reid Schindler and Fine, {Stuart L.} and Marilyn Katz and Mary Brightwell-Arnold and Ruchira Glaser and Judith Hall and Sandra Harkins and Jiayan Huang and Alexander Khvatov and Kathy McWilliams and Ellen Peskin and Maxwell Pistilli and Susan Ryan and Allison Schnader and Jennifer Afrani-Sakyi and Brannon Balsley and Bennett, {Linda S.} and Adam Brooks and Adrienne Brower-Lingsch and Lori Bruce and Dee Busian and John Choong and Lindsey Cloaninger and DeCroos, {Francis Char} and Emily Dubois and Mays El-Dairi and Sarah Gach and Katelyn Hall and Terry Hawks and Chengchenh Huang and Cindy Heydary and Alexander Ho and Shashi Kini and Michelle McCall and Daaimah Muhammad and Jayne Nicholson and Pamela Rieves and Kelly Shields and Adam Specker and Sandra Stinnett and Sujatha Subramaniam and Patrick Tenbrink and Aaron Towe and Kimberly Welch and Natasha Williams and Katrina Winter and Ellen Young and Judith Alexander and Elisabeth Flannagan and Martin, {E. Revell} and Candace Parker and Krista Sepielli and Tom Shannon and Claressa Whearry and Maryann Redford and Kopfer, {Marcia R.} and Ferris, {Frederick L.} and Joan Dupont and Friedman, {Lawrence M.} and Bressler, {Susan B.} and Demets, {David L.} and Martin Friedlander and Johnson, {Mark W.} and Anne Lindblad and Losordo, {Douglas W.} and Miller, {Franklin G.}",
year = "2015",
month = "9",
day = "1",
doi = "10.1016/j.ophtha.2015.05.042",
language = "English (US)",
volume = "122",
pages = "1846--1853",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "9",

}

TY - JOUR

T1 - Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials

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AU - Dev, Sundeep

AU - Enloe, Julianne

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AU - Johnson, Jill

AU - Jones, Tori

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AU - Arnwine, Jean

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AU - Bell, Tina

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AU - Duignan, Karen

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AU - Jaramillo, Diana

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AU - Kaiser, Richard

AU - Affel, Elizabeth

AU - Brown, Gary

AU - Centinaro, Christina

AU - Fine, Deborah

AU - Fineman, Mitchell

AU - Formoso, Michele

AU - Garg, Sunir

AU - Grande, Lisa

AU - Herbert, Carolyn

AU - Ho, Allen

AU - Hsu, Jason

AU - Jay, Maryann

AU - Lavetsky, Lisa

AU - Liebenbaum, Elaine

AU - Maguire, Joseph

AU - Monsonego, Julia

AU - O'Connor, Lucia

AU - Pierce, Lisa

AU - Regillo, Carl

AU - Rosario, Maria

AU - Spirn, Marc

AU - Vander, James

AU - Walsh, Jennifer

AU - Davidorf, Frederick H.

AU - Barnett, Amanda

AU - Chang, Susie

AU - Christoforidis, John B

AU - Elliott, Joy

AU - Justice, Heather

AU - Letson, Alan

AU - McKinney, Kathryne

AU - Perry, Jeri

AU - Salerno, Jill A.

AU - Savage, Scott

AU - Shelley, Stephen

AU - Singerman, Lawrence J.

AU - Coney, Joseph

AU - Dubois, John

AU - Dubois, Kimberly

AU - Greanoff, Gregg

AU - Himmelman, Dianne

AU - Ilc, Mary

AU - McNamara, Elizabeth

AU - Novak, Michael

AU - Pendergast, Scott

AU - Rath, Susan

AU - Smith-Brewer, Sheila

AU - Tanner, Vivian

AU - Weiss, Diane E.

AU - Zegarra, Hernando

AU - Halperin, Lawrence

AU - Aramayo, Patricia

AU - Dhalla, Mandeep

AU - Fernandez, Brian

AU - Fernandez, Cindy

AU - Lopez, Jaclyn

AU - Lopez, Monica

AU - Mariano, Jamie

AU - Murphy, Kellie

AU - Sherley, Clifford

AU - Veksler, Rita

AU - Rahhal, Firas

AU - Babikian, Razmig

AU - Boyer, David

AU - Hami, Sepideh

AU - Kessinger, Jeff

AU - Kurokouchi, Janet

AU - Mukarram, Saba

AU - Pachman, Sarah

AU - Protacio, Eric

AU - Sierra, Julio

AU - Tabandeh, Homayoun

AU - Zamboni, Adam

AU - Elman, Michael

AU - Belz, Jennifer

AU - Butcher, Tammy

AU - Cain, Theresa

AU - Coffey, Teresa

AU - Firestone, Dena

AU - Gore, Nancy

AU - Singletary, Pamela

AU - Sotirakos, Peter

AU - Starr, Joann

AU - Meredith, Travis A.

AU - Barnhart, Cassandra J.

AU - Cantrell, Debra

AU - Esquejo-Leon, Ronalyn

AU - Houghton, Odette

AU - Kaur, Harpreet

AU - Ndure, Fatoumatta

AU - Glatzer, Ronald

AU - Joffe, Leonard

AU - Schindler, Reid

AU - Fine, Stuart L.

AU - Katz, Marilyn

AU - Brightwell-Arnold, Mary

AU - Glaser, Ruchira

AU - Hall, Judith

AU - Harkins, Sandra

AU - Huang, Jiayan

AU - Khvatov, Alexander

AU - McWilliams, Kathy

AU - Peskin, Ellen

AU - Pistilli, Maxwell

AU - Ryan, Susan

AU - Schnader, Allison

AU - Afrani-Sakyi, Jennifer

AU - Balsley, Brannon

AU - Bennett, Linda S.

AU - Brooks, Adam

AU - Brower-Lingsch, Adrienne

AU - Bruce, Lori

AU - Busian, Dee

AU - Choong, John

AU - Cloaninger, Lindsey

AU - DeCroos, Francis Char

AU - Dubois, Emily

AU - El-Dairi, Mays

AU - Gach, Sarah

AU - Hall, Katelyn

AU - Hawks, Terry

AU - Huang, Chengchenh

AU - Heydary, Cindy

AU - Ho, Alexander

AU - Kini, Shashi

AU - McCall, Michelle

AU - Muhammad, Daaimah

AU - Nicholson, Jayne

AU - Rieves, Pamela

AU - Shields, Kelly

AU - Specker, Adam

AU - Stinnett, Sandra

AU - Subramaniam, Sujatha

AU - Tenbrink, Patrick

AU - Towe, Aaron

AU - Welch, Kimberly

AU - Williams, Natasha

AU - Winter, Katrina

AU - Young, Ellen

AU - Alexander, Judith

AU - Flannagan, Elisabeth

AU - Martin, E. Revell

AU - Parker, Candace

AU - Sepielli, Krista

AU - Shannon, Tom

AU - Whearry, Claressa

AU - Redford, Maryann

AU - Kopfer, Marcia R.

AU - Ferris, Frederick L.

AU - Dupont, Joan

AU - Friedman, Lawrence M.

AU - Bressler, Susan B.

AU - Demets, David L.

AU - Friedlander, Martin

AU - Johnson, Mark W.

AU - Lindblad, Anne

AU - Losordo, Douglas W.

AU - Miller, Franklin G.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Purpose To evaluate the association of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA), and scar in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Design Prospective cohort study within a randomized clinical trial. Participants The 1185 CATT participants. Methods Masked readers graded scar and GA on fundus photography and fluorescein angiography and graded SHRM on time-domain and spectral-domain (SD) optical coherence tomography (OCT) throughout 104 weeks. Measurements of SHRM height and width in the fovea, within the center 1 mm2, or outside the center 1mm2 were obtained on SD OCT images at 56 (n = 76) and 104 (n = 66) weeks. Main Outcome Measures Presence of SHRM, as well as location and size, and associations with VA, scar, and GA. Results Among CATT participants, the percentage with SHRM at enrollment was 77%, decreasing to 68% at 4 weeks after treatment and to 54% at 104 weeks. At 104 weeks, scar was present more often in eyes with persistent SHRM than in eyes with SHRM that resolved (64% vs. 31%; P <0.0001). Among eyes with detailed evaluation of SHRM at weeks 56 (n = 76) and 104 (n = 66), mean VA letter score was 73.5 (standard error [SE], 2.8), 73.1 (SE, 3.4), 65.3 (SE, 3.5), and 63.9 (SE, 3.7) when SHRM was absent, present outside the central 1 mm2, present within the central 1 mm2 but not the foveal center, or present at the foveal center (P = 0.02), respectively. When SHRM was present, the median maximum height under the fovea, within the central 1 mm2 including the fovea and anywhere within the scan, was 86 μm, 120 μm, and 122 μm, respectively. Visual acuity was decreased with greater SHRM height and width (P <0.05). Conclusions In eyes with neovascular age-related macular degeneration (AMD), SHRM is common and often persists after anti-vascular endothelial growth factor treatment. At 2 years, eyes with scar were more likely to have SHRM than other eyes. Greater SHRM dimensions were associated with worse VA. In eyes with neovascular AMD, SHRM is an important morphologic biomarker.

AB - Purpose To evaluate the association of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA), and scar in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Design Prospective cohort study within a randomized clinical trial. Participants The 1185 CATT participants. Methods Masked readers graded scar and GA on fundus photography and fluorescein angiography and graded SHRM on time-domain and spectral-domain (SD) optical coherence tomography (OCT) throughout 104 weeks. Measurements of SHRM height and width in the fovea, within the center 1 mm2, or outside the center 1mm2 were obtained on SD OCT images at 56 (n = 76) and 104 (n = 66) weeks. Main Outcome Measures Presence of SHRM, as well as location and size, and associations with VA, scar, and GA. Results Among CATT participants, the percentage with SHRM at enrollment was 77%, decreasing to 68% at 4 weeks after treatment and to 54% at 104 weeks. At 104 weeks, scar was present more often in eyes with persistent SHRM than in eyes with SHRM that resolved (64% vs. 31%; P <0.0001). Among eyes with detailed evaluation of SHRM at weeks 56 (n = 76) and 104 (n = 66), mean VA letter score was 73.5 (standard error [SE], 2.8), 73.1 (SE, 3.4), 65.3 (SE, 3.5), and 63.9 (SE, 3.7) when SHRM was absent, present outside the central 1 mm2, present within the central 1 mm2 but not the foveal center, or present at the foveal center (P = 0.02), respectively. When SHRM was present, the median maximum height under the fovea, within the central 1 mm2 including the fovea and anywhere within the scan, was 86 μm, 120 μm, and 122 μm, respectively. Visual acuity was decreased with greater SHRM height and width (P <0.05). Conclusions In eyes with neovascular age-related macular degeneration (AMD), SHRM is common and often persists after anti-vascular endothelial growth factor treatment. At 2 years, eyes with scar were more likely to have SHRM than other eyes. Greater SHRM dimensions were associated with worse VA. In eyes with neovascular AMD, SHRM is an important morphologic biomarker.

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U2 - 10.1016/j.ophtha.2015.05.042

DO - 10.1016/j.ophtha.2015.05.042

M3 - Article

VL - 122

SP - 1846

EP - 1853

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 9

ER -