Substance P and Inflammatory Pain: Getting It Wrong and Right Simultaneously

Edita Navratilova, Frank Porreca

Research output: Contribution to journalShort survey

5 Scopus citations

Abstract

How do neuropeptides participate in the classic neuroinflammatory sequelae of tissue injury that includes pain, immune cell infiltration, and swelling? In this issue of Neuron, Green et al. (2019) reveal that MrgprB2/MrgprX2 is a mast cell substance-P-specific receptor that critically links neural and immune systems and offers new approaches for neuroinflammatory therapeutics.

Original languageEnglish (US)
Pages (from-to)353-355
Number of pages3
JournalNeuron
Volume101
Issue number3
DOIs
StatePublished - Feb 6 2019

Keywords

  • MrgprB2 receptor
  • NK1 receptor
  • mast cells
  • neuroinflammation
  • pain
  • substance P

ASJC Scopus subject areas

  • Neuroscience(all)

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