Subthalamic nucleus deep brain stimulation improves deglutition in Parkinson's disease

Michelle R. Ciucci, Julie M. Barkmeier-Kraemer, Scott J Sherman

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Relatively little is known about the role of the basal ganglia in human deglutition. Deep brain stimulation (DBS) affords us a model for examining deglutition in humans with known impairment of the basal ganglia. The purpose of this study was to examine the effects of subthalamic nuclei (STN) DBS on the oral and pharyngeal stages of deglutition in individuals with Parkinson's Disease (PD). It was hypothesized that DBS would be associated with improved deglutition. Within participant, comparisons were made between DBS in the ON and OFF conditions using the dependent variables: pharyngeal transit time, maximal hyoid bone excursion, oral total composite score, and pharyngeal total composite score. Significant improvement occurred for the pharyngeal composite score and pharyngeal transit time in the DBS ON condition compared with DBS OFF. Stimulation of the STN may excite thalamocortical or brainstem targets to sufficiently overcome the bradykinesia/hypokinesia associated with PD and return some pharyngeal stage motor patterns to performance levels approximating those of "normal" deglutition. However, the degree of hyoid bone excursion and oral stage measures did not improve, suggesting that these motor acts may be under the control of different sensorimotor pathways within the basal ganglia.

Original languageEnglish (US)
Pages (from-to)676-683
Number of pages8
JournalMovement Disorders
Volume23
Issue number5
DOIs
StatePublished - Apr 15 2008

Fingerprint

Subthalamic Nucleus
Deep Brain Stimulation
Deglutition
Parkinson Disease
Oral Stage
Basal Ganglia
Hyoid Bone
Hypokinesia
Brain Stem

Keywords

  • Deep brain stimulation
  • Deglutition
  • Dysphagia
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Subthalamic nucleus deep brain stimulation improves deglutition in Parkinson's disease. / Ciucci, Michelle R.; Barkmeier-Kraemer, Julie M.; Sherman, Scott J.

In: Movement Disorders, Vol. 23, No. 5, 15.04.2008, p. 676-683.

Research output: Contribution to journalArticle

Ciucci, Michelle R. ; Barkmeier-Kraemer, Julie M. ; Sherman, Scott J. / Subthalamic nucleus deep brain stimulation improves deglutition in Parkinson's disease. In: Movement Disorders. 2008 ; Vol. 23, No. 5. pp. 676-683.
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