Sucralfate reduces the gastrointestinal absorption of norfloxacin

S. H. Parpia, David E. Nix, L. G. Hejmanowski, H. R. Goldstein, J. H. Wilton, J. J. Schentag

Research output: Contribution to journalArticle

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Abstract

The effect of sucralfate on the bioavailability of norfloxacin after single 400-mg doses of norfloxacin was evaluated in eight healthy males. Subjects received each of the following treatments in random sequence: (i), norfloxacin, 400 mg alone; (ii) sucralfate, 1 g, concurrently with norfloxacin, 400 mg; and (iii) sucralfate, 1 g, followed by norfloxacin, 400 mg, 2 h later. One day before administration of treatments 2 and 3, 1 g of sucralfate was given at 7 a.m., 11 a.m., 5 p.m., and 10 p.m. Blood samples were collected immediately before the norfloxacin dose and at 0.25, 0.5, 0.75, 1.0, 1.5, 2, 3, 4, 6, 8, 12, and 24 h postdose. Urine was collected in divided intervals: from 0 to 12, from 12 to 24, and from 24 to 48 h. Norfloxacin concentrations in plasma and urine were determined by high-performance liquid chromatography. Mean area under the plasma concentration-versus-time curve extrapolated to infinity decreased significantly (P < 0.001) after norfloxacin was given with and 2 h after sucralfate. The relative bioavailabilities were 1.8% when norfloxacin was taken with sucralfate and 56.6% when it was taken 2 h after sucralfate. After norfloxacin was given alone, the mean norfloxacin concentrations in urine collected during intervals of 0 to 12, 12 to 24, and 24 to 28 h were 118.9 ± 72.3, 18.8 ± 12.5, and 2.4 ± 2.2 μg/ml, respectively. After norfloxacin was given with sucralfate, however, the mean norfloxacin concentrations in urine collected during the same time intervals were 6.8 ± 4.7, 1.8 ± 1.4, and 0 ± 0 μg/ml, respectively. Because of low pH and relatively high magnesium concentration in urine, susceptibilities of bacteria in urine are 8- to 32-fold lower than in broth. This fact, in combination with the reduced bioavailability of norfloxacin in the presence of sucralfate or antacids, is likely to result in treatment failure. The effect of sucralfate given after norfloxacin was not examined, nor was the effect of sucralfate given more than 2 h before norfloxacin. Administration of norfloxacin with sucralfate should therefore be avoided.

Original languageEnglish (US)
Pages (from-to)99-102
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume33
Issue number1
StatePublished - 1989
Externally publishedYes

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Sucralfate
Norfloxacin
Urine
Biological Availability
Gastrointestinal Absorption
Antacids

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Parpia, S. H., Nix, D. E., Hejmanowski, L. G., Goldstein, H. R., Wilton, J. H., & Schentag, J. J. (1989). Sucralfate reduces the gastrointestinal absorption of norfloxacin. Antimicrobial Agents and Chemotherapy, 33(1), 99-102.

Sucralfate reduces the gastrointestinal absorption of norfloxacin. / Parpia, S. H.; Nix, David E.; Hejmanowski, L. G.; Goldstein, H. R.; Wilton, J. H.; Schentag, J. J.

In: Antimicrobial Agents and Chemotherapy, Vol. 33, No. 1, 1989, p. 99-102.

Research output: Contribution to journalArticle

Parpia, SH, Nix, DE, Hejmanowski, LG, Goldstein, HR, Wilton, JH & Schentag, JJ 1989, 'Sucralfate reduces the gastrointestinal absorption of norfloxacin', Antimicrobial Agents and Chemotherapy, vol. 33, no. 1, pp. 99-102.
Parpia SH, Nix DE, Hejmanowski LG, Goldstein HR, Wilton JH, Schentag JJ. Sucralfate reduces the gastrointestinal absorption of norfloxacin. Antimicrobial Agents and Chemotherapy. 1989;33(1):99-102.
Parpia, S. H. ; Nix, David E. ; Hejmanowski, L. G. ; Goldstein, H. R. ; Wilton, J. H. ; Schentag, J. J. / Sucralfate reduces the gastrointestinal absorption of norfloxacin. In: Antimicrobial Agents and Chemotherapy. 1989 ; Vol. 33, No. 1. pp. 99-102.
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