Sulfhemoglobinemia after dermal application of DMSO

Jefferey L Burgess, Albert P. Hamner, William O. Robertson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A 43-y-old Caucasian female applied 4 ounces of dimethyl sulfoxide (DMSO) to her lower abdomen for treatment of interstitial cystitis. Within 24 h she developed fatigue, cyanosis and dyspnea with mild exertion. She sought medical attention 10 d later, at which time initial laboratory tests revealed a methemoglobin level of 47%. Two doses of 1 mg methylene blue/kg iv were given without significant improvement in either her cyanosis or methemoglobin level. Repeat analysis the day following admission using an outside lab demonstrated a sulfhemoglobin level of 6.2% and a methemoglobin level of <0.1%. No prior reports have associated sulfhemoglobin formation with DMSO application. Carbon monoxide-oximetry may falsely identify sulfhemoglobin as methemoglobin; sulfhemoglobinemia should be considered in cases of methemoglobinemia refractory to methylene blue therapy.

Original languageEnglish (US)
Pages (from-to)87-89
Number of pages3
JournalVeterinary and Human Toxicology
Volume40
Issue number2
StatePublished - 1998
Externally publishedYes

Fingerprint

Sulfhemoglobinemia
Sulfhemoglobin
Methemoglobin
methylene blue
dimethyl sulfoxide
Dimethyl Sulfoxide
methemoglobinemia
cystitis
Skin
Cyanosis
carbon monoxide
Methylene Blue
dyspnea
abdomen
Methemoglobinemia
Interstitial Cystitis
therapeutics
Oximetry
Carbon Monoxide
dosage

ASJC Scopus subject areas

  • veterinary(all)
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Sulfhemoglobinemia after dermal application of DMSO. / Burgess, Jefferey L; Hamner, Albert P.; Robertson, William O.

In: Veterinary and Human Toxicology, Vol. 40, No. 2, 1998, p. 87-89.

Research output: Contribution to journalArticle

Burgess, JL, Hamner, AP & Robertson, WO 1998, 'Sulfhemoglobinemia after dermal application of DMSO', Veterinary and Human Toxicology, vol. 40, no. 2, pp. 87-89.
Burgess, Jefferey L ; Hamner, Albert P. ; Robertson, William O. / Sulfhemoglobinemia after dermal application of DMSO. In: Veterinary and Human Toxicology. 1998 ; Vol. 40, No. 2. pp. 87-89.
@article{d6cc45b33cfb4d01b47625654740167c,
title = "Sulfhemoglobinemia after dermal application of DMSO",
abstract = "A 43-y-old Caucasian female applied 4 ounces of dimethyl sulfoxide (DMSO) to her lower abdomen for treatment of interstitial cystitis. Within 24 h she developed fatigue, cyanosis and dyspnea with mild exertion. She sought medical attention 10 d later, at which time initial laboratory tests revealed a methemoglobin level of 47{\%}. Two doses of 1 mg methylene blue/kg iv were given without significant improvement in either her cyanosis or methemoglobin level. Repeat analysis the day following admission using an outside lab demonstrated a sulfhemoglobin level of 6.2{\%} and a methemoglobin level of <0.1{\%}. No prior reports have associated sulfhemoglobin formation with DMSO application. Carbon monoxide-oximetry may falsely identify sulfhemoglobin as methemoglobin; sulfhemoglobinemia should be considered in cases of methemoglobinemia refractory to methylene blue therapy.",
author = "Burgess, {Jefferey L} and Hamner, {Albert P.} and Robertson, {William O.}",
year = "1998",
language = "English (US)",
volume = "40",
pages = "87--89",
journal = "Veterinary and Human Toxicology",
issn = "0145-6296",
publisher = "Comparative Toxicology Laboratories",
number = "2",

}

TY - JOUR

T1 - Sulfhemoglobinemia after dermal application of DMSO

AU - Burgess, Jefferey L

AU - Hamner, Albert P.

AU - Robertson, William O.

PY - 1998

Y1 - 1998

N2 - A 43-y-old Caucasian female applied 4 ounces of dimethyl sulfoxide (DMSO) to her lower abdomen for treatment of interstitial cystitis. Within 24 h she developed fatigue, cyanosis and dyspnea with mild exertion. She sought medical attention 10 d later, at which time initial laboratory tests revealed a methemoglobin level of 47%. Two doses of 1 mg methylene blue/kg iv were given without significant improvement in either her cyanosis or methemoglobin level. Repeat analysis the day following admission using an outside lab demonstrated a sulfhemoglobin level of 6.2% and a methemoglobin level of <0.1%. No prior reports have associated sulfhemoglobin formation with DMSO application. Carbon monoxide-oximetry may falsely identify sulfhemoglobin as methemoglobin; sulfhemoglobinemia should be considered in cases of methemoglobinemia refractory to methylene blue therapy.

AB - A 43-y-old Caucasian female applied 4 ounces of dimethyl sulfoxide (DMSO) to her lower abdomen for treatment of interstitial cystitis. Within 24 h she developed fatigue, cyanosis and dyspnea with mild exertion. She sought medical attention 10 d later, at which time initial laboratory tests revealed a methemoglobin level of 47%. Two doses of 1 mg methylene blue/kg iv were given without significant improvement in either her cyanosis or methemoglobin level. Repeat analysis the day following admission using an outside lab demonstrated a sulfhemoglobin level of 6.2% and a methemoglobin level of <0.1%. No prior reports have associated sulfhemoglobin formation with DMSO application. Carbon monoxide-oximetry may falsely identify sulfhemoglobin as methemoglobin; sulfhemoglobinemia should be considered in cases of methemoglobinemia refractory to methylene blue therapy.

UR - http://www.scopus.com/inward/record.url?scp=0031894209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031894209&partnerID=8YFLogxK

M3 - Article

C2 - 9554060

AN - SCOPUS:0031894209

VL - 40

SP - 87

EP - 89

JO - Veterinary and Human Toxicology

JF - Veterinary and Human Toxicology

SN - 0145-6296

IS - 2

ER -