Sultam thiourea inhibition of West Nile virus

Eric Barklis, Amelia Still, Mohammad I. Sabri, Alec J. Hirsch, Janko Nikolich-Zugich, James Brien, Tenzin Choesang Dhenub, Isabel Scholz, Ayna Alfadhli

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.

Original languageEnglish (US)
Pages (from-to)2642-2645
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

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West Nile virus
Thiourea
Virus Replication
Replicon
naphthosultone

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Barklis, E., Still, A., Sabri, M. I., Hirsch, A. J., Nikolich-Zugich, J., Brien, J., ... Alfadhli, A. (2007). Sultam thiourea inhibition of West Nile virus. Antimicrobial Agents and Chemotherapy, 51(7), 2642-2645. https://doi.org/10.1128/AAC.00007-07

Sultam thiourea inhibition of West Nile virus. / Barklis, Eric; Still, Amelia; Sabri, Mohammad I.; Hirsch, Alec J.; Nikolich-Zugich, Janko; Brien, James; Dhenub, Tenzin Choesang; Scholz, Isabel; Alfadhli, Ayna.

In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 7, 07.2007, p. 2642-2645.

Research output: Contribution to journalArticle

Barklis, E, Still, A, Sabri, MI, Hirsch, AJ, Nikolich-Zugich, J, Brien, J, Dhenub, TC, Scholz, I & Alfadhli, A 2007, 'Sultam thiourea inhibition of West Nile virus', Antimicrobial Agents and Chemotherapy, vol. 51, no. 7, pp. 2642-2645. https://doi.org/10.1128/AAC.00007-07
Barklis, Eric ; Still, Amelia ; Sabri, Mohammad I. ; Hirsch, Alec J. ; Nikolich-Zugich, Janko ; Brien, James ; Dhenub, Tenzin Choesang ; Scholz, Isabel ; Alfadhli, Ayna. / Sultam thiourea inhibition of West Nile virus. In: Antimicrobial Agents and Chemotherapy. 2007 ; Vol. 51, No. 7. pp. 2642-2645.
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