Sultam thiourea inhibition of West Nile virus

Eric Barklis, Amelia Still, Mohammad I. Sabri, Alec J. Hirsch, Janko Nikolich-Zugich, James Brien, Tenzin Choesang Dhenub, Isabel Scholz, Ayna Alfadhli

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.

Original languageEnglish (US)
Pages (from-to)2642-2645
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number7
DOIs
StatePublished - Jul 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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  • Cite this

    Barklis, E., Still, A., Sabri, M. I., Hirsch, A. J., Nikolich-Zugich, J., Brien, J., Dhenub, T. C., Scholz, I., & Alfadhli, A. (2007). Sultam thiourea inhibition of West Nile virus. Antimicrobial Agents and Chemotherapy, 51(7), 2642-2645. https://doi.org/10.1128/AAC.00007-07