Sunburns and Risk of Cutaneous Melanoma: Does Age Matter? A Comprehensive Meta-Analysis

Leslie K Dennis, Marta J. Vanbeek, Laura E. Beane Freeman, Brian J. Smith, Deborah V. Dawson, Julie A. Coughlin

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Purpose: Sunburns are an important risk factor for melanoma and those occurring in childhood are often cited as posing the greatest risk. We conducted a meta-analysis to quantify the magnitude of association for melanoma and sunburns during childhood, adolescence, adulthood and over a lifetime. Methods: After reviewing over 1300 article titles and evaluating 270 articles in detail, we pooled odds ratios from 51 independent study populations for "ever" sunburned and risk of cutaneous melanoma. Among these, 26 studies reported results from dose-response analyses. Dose-response analyses were examined using both fixed-effects models and Bayesian random-effects models. Results: An increased risk of melanoma was seen with increasing number of sunburns for all time-periods (childhood, adolescence, adulthood, and lifetime). In an attempt to understand how risk between life-periods compares, we also report these same linear models on a scale of five sunburns per decade for each life-period. The magnitude of risk for five sunburns per decade is highest for adult and lifetime sunburns. Conclusions: Overall, these results show an increased risk of melanoma with increasing number of sunburns during all life-periods, not just childhood. Prevention efforts should focus on reducing sunburns during all life-periods.

Original languageEnglish (US)
Pages (from-to)614-627
Number of pages14
JournalAnnals of Epidemiology
Volume18
Issue number8
DOIs
StatePublished - Aug 2008
Externally publishedYes

Fingerprint

Sunburn
Meta-Analysis
Melanoma
Skin
Linear Models
Odds Ratio

Keywords

  • Adolescent
  • Adult
  • Child
  • Intermittent Sun Exposure
  • Melanoma
  • Meta-Analysis
  • Odds Ratio
  • Sun Sensitivity
  • Sunburn

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Dennis, L. K., Vanbeek, M. J., Beane Freeman, L. E., Smith, B. J., Dawson, D. V., & Coughlin, J. A. (2008). Sunburns and Risk of Cutaneous Melanoma: Does Age Matter? A Comprehensive Meta-Analysis. Annals of Epidemiology, 18(8), 614-627. https://doi.org/10.1016/j.annepidem.2008.04.006

Sunburns and Risk of Cutaneous Melanoma : Does Age Matter? A Comprehensive Meta-Analysis. / Dennis, Leslie K; Vanbeek, Marta J.; Beane Freeman, Laura E.; Smith, Brian J.; Dawson, Deborah V.; Coughlin, Julie A.

In: Annals of Epidemiology, Vol. 18, No. 8, 08.2008, p. 614-627.

Research output: Contribution to journalArticle

Dennis, LK, Vanbeek, MJ, Beane Freeman, LE, Smith, BJ, Dawson, DV & Coughlin, JA 2008, 'Sunburns and Risk of Cutaneous Melanoma: Does Age Matter? A Comprehensive Meta-Analysis', Annals of Epidemiology, vol. 18, no. 8, pp. 614-627. https://doi.org/10.1016/j.annepidem.2008.04.006
Dennis, Leslie K ; Vanbeek, Marta J. ; Beane Freeman, Laura E. ; Smith, Brian J. ; Dawson, Deborah V. ; Coughlin, Julie A. / Sunburns and Risk of Cutaneous Melanoma : Does Age Matter? A Comprehensive Meta-Analysis. In: Annals of Epidemiology. 2008 ; Vol. 18, No. 8. pp. 614-627.
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