[125I]SNF 8702: A selective radioligand for CCKB receptors

Jirina Slaninova, Richard J. Knapp, Steven J. Weber, Thomas P. Davis, Su Nan Fang, Victor J. Hruby, Henry I. Yamamura

Research output: Contribution to journalArticle

1 Scopus citations


The CCK-8 analogue, SNF 8702, was radioiodinated. [125I]SNF 8702 showed high-affinity specific binding for both guinea pig and mouse brain tissues, whereas no specific binding was seen for guinea pig pancreatic tissue. The properties of the site labeled by [125I]SNF 8702 were characterized by binding inhibition studies for a series of CCKA and CCKB receptor ligands. The binding selectivity profile corresponded to that for the CCKB receptor. The labeled compound is stable for more than 6 weeks during storage at -20°C.

Original languageEnglish (US)
Pages (from-to)221-224
Number of pages4
Issue number2
StatePublished - 1995


  • CCK receptors
  • Cholecystokinin
  • Radioiodinated cholecystokinin analogue
  • SNF 8702

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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    Slaninova, J., Knapp, R. J., Weber, S. J., Davis, T. P., Fang, S. N., Hruby, V. J., & Yamamura, H. I. (1995). [125I]SNF 8702: A selective radioligand for CCKB receptors. Peptides, 16(2), 221-224. https://doi.org/10.1016/0196-9781(94)00168-5