[125I]SNF 8702: A selective radioligand for CCKB receptors

Jirina Slaninova, Richard J. Knapp, Steven J. Weber, Thomas P. Davis, Su Nan Fang, Victor J. Hruby, Henry I. Yamamura

Research output: Research - peer-reviewArticle

  • 1 Citations

Abstract

The CCK-8 analogue, SNF 8702, was radioiodinated. [125I]SNF 8702 showed high-affinity specific binding for both guinea pig and mouse brain tissues, whereas no specific binding was seen for guinea pig pancreatic tissue. The properties of the site labeled by [125I]SNF 8702 were characterized by binding inhibition studies for a series of CCKA and CCKB receptor ligands. The binding selectivity profile corresponded to that for the CCKB receptor. The labeled compound is stable for more than 6 weeks during storage at -20°C.

LanguageEnglish (US)
Pages221-224
Number of pages4
JournalPeptides
Volume16
Issue number2
DOIs
StatePublished - 1995

Fingerprint

SNF 8702
Tissue
Guinea Pigs
Sincalide
Brain
Ligands

Keywords

  • CCK receptors
  • Cholecystokinin
  • Radioiodinated cholecystokinin analogue
  • SNF 8702

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Slaninova, J., Knapp, R. J., Weber, S. J., Davis, T. P., Fang, S. N., Hruby, V. J., & Yamamura, H. I. (1995). [125I]SNF 8702: A selective radioligand for CCKB receptors. Peptides, 16(2), 221-224. DOI: 10.1016/0196-9781(94)00168-5

[125I]SNF 8702 : A selective radioligand for CCKB receptors. / Slaninova, Jirina; Knapp, Richard J.; Weber, Steven J.; Davis, Thomas P.; Fang, Su Nan; Hruby, Victor J.; Yamamura, Henry I.

In: Peptides, Vol. 16, No. 2, 1995, p. 221-224.

Research output: Research - peer-reviewArticle

Slaninova, J, Knapp, RJ, Weber, SJ, Davis, TP, Fang, SN, Hruby, VJ & Yamamura, HI 1995, '[125I]SNF 8702: A selective radioligand for CCKB receptors' Peptides, vol 16, no. 2, pp. 221-224. DOI: 10.1016/0196-9781(94)00168-5
Slaninova J, Knapp RJ, Weber SJ, Davis TP, Fang SN, Hruby VJ et al. [125I]SNF 8702: A selective radioligand for CCKB receptors. Peptides. 1995;16(2):221-224. Available from, DOI: 10.1016/0196-9781(94)00168-5
Slaninova, Jirina ; Knapp, Richard J. ; Weber, Steven J. ; Davis, Thomas P. ; Fang, Su Nan ; Hruby, Victor J. ; Yamamura, Henry I./ [125I]SNF 8702 : A selective radioligand for CCKB receptors. In: Peptides. 1995 ; Vol. 16, No. 2. pp. 221-224
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