31P-Nmr as a probe for drug-nucleic acid interactions

Frederick C. Seaman, Laurence H. Hurley

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The structural impact of covalent and noncovalent interactions of drugs with DNA is an important component for understanding the biochemical and biological consequences of DNA damage. Work in this laboratory has focused on a number of potentially therapeutically important drugs that distort DNA by unwinding, bending DNA into the major or minor groove. These lead to enhanced recognition of DNA by proteins involved in transcription and replication. In this paper, we will present the structures of one of these complexes and show how 31P-NMR can be used to monitor these distortive effects.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalPhosphorus, Sulfur and Silicon and Related Elements
Volume144-146
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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Keywords

  • Bizelesin
  • Drug-DNA
  • Ecteinascidin
  • P-NMR
  • Quinolone

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Inorganic Chemistry

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