99mtc glucarate high-resolution imaging of drug sensitive and drug resistant human breast cancer xenografts in scid mice

Zhonglin Liu, Gail D. Stevenson, Harrison H. Barrett, George A. Kastis, Michel Bettan, Lars R. Furenlid, Donald W. Wilson, James M. Woolfenden, Koon Yan Pak

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Previous studies have showed that 99mTc labelled glucarate (GLA) might be an agent for non-invasive detection of breast tumours. In xenografted BT20 breast tumours, GLA was found to have higher uptake than 99mTc sestamibi (MIBI). It is unclear whether GLA can localize in all cell line breast cancer xenografts, as well as breast tumours with multidrug resistance (MDR). The present study aimed to investigate the properties of GLA in detecting drug sensitive and drug resistant MCF7 breast cancer xenografts in mice by using dynamic single photon emission computed tomography (SPECT) imaging.

Original languageEnglish (US)
Pages (from-to)711-720
Number of pages10
JournalNuclear Medicine Communications
Volume25
Issue number7
DOIs
StatePublished - Jul 2004

Keywords

  • Breast cancer
  • High-resolution SPECT
  • Multidrug resistant
  • SCID mice
  • Tc glucarate
  • Tc sestamibi

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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