Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation

Frank P. Zemlan, Ole J. Thienhaus, H. Bruce Bosmann

Research output: Contribution to journalArticlepeer-review

156 Scopus citations

Abstract

Activity of the free radical scavenging enzyme, superoxide dismutase (SOD-1), was determined in fibroblast cell lines derived from familial Alzheimer's patients, trisomy 21 patients and normal controls. In the present study, SOD-1 activity was significantly elevated by 30% in Alzheimer's cell lines when compared to normal euploid cell lines. As SOD-1 activity is known to be elevated about 50% in trisomy 21 patients, these cell lines were included as a control for tissue culture and assay conditions. In the present study, SOD-1 activity was significantly increased by 42±11% in trisomy 21 patients. The elevation in SOD-1 activity observed in the familial Alzheimer's patients supports the theory that paired helical filaments are synthesized in Alzheimer's disease by free radical hydroxylation of proline residues in paired helical filament precursor protein(s).

Original languageEnglish (US)
Pages (from-to)160-162
Number of pages3
JournalBrain Research
Volume476
Issue number1
DOIs
StatePublished - Jan 2 1989
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Free radical
  • Neurodegenerative disorder
  • Paired helical filament
  • Senile plaques
  • Superoxide dismutase

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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