Supplemental oxygen improves resolution of injury-induced pneumothorax

Dustin Zierold, Steven L. Lee, Sreekumar - Subramanian, Jeffrey J. Dubois

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background/Purpose: Traditionally, supplemental oxygen is administered to patients with asymptomatic pneumothorax to accelerate spontaneous resolution. However, this practice is based on models that did not include injury to the visceral pleura and ongoing pleural air leak. This study evaluated the effects of increased inspired oxygen concentration on pneumothorax resolution in a visceral pleural injury model. Methods: A total of 27 New Zealand white rabbits were divided randomly into 3 groups: room air (RA), 40% FIO 2 (40%), and 60% FIO 2 (60%). A complete unilateral pneumothorax was created in each animal by a thoracoscopically guided visceral pleural puncture. The animals were then housed in designated oxygen chambers, and observers were blinded to the inspired oxygen concentration. Cross table anteroposterior chest x-rays were obtained preoperatively, postoperatively, and twice a day until the pneumothorax resolved. Time to resolution between the 3 groups was analyzed with 1-way analysis of variance (ANOVA). Results: Twenty of 27 (74%) of the animals completed the study successfully. Mean time to resolution in the RA group (n = 7; 111.2 ± 30.8 hours) was longer than in the 40% group (n = 6; 71.8 ± 22.3 hours) and the 60% group (n=7; 39.4 ± 14.2 hours). The time to resolution also was longer in the 40% group than in the 60% group. Seven rabbits died before completion of the study of tension pneumothorax (3 of 7) or anesthetic complications (4 of 7). Conclusions: Supplemental oxygen improves resolution of injury-induced pneumothorax. The tradition of administering supplemental oxygen to patients with asymptomatic pneumothorax should be continued even if there is ongoing pleural air leak.

Original languageEnglish (US)
Pages (from-to)998-1001
Number of pages4
JournalJournal of Pediatric Surgery
Volume35
Issue number6
StatePublished - Jun 2000
Externally publishedYes

Fingerprint

Pneumothorax
Oxygen
Wounds and Injuries
Air
Rabbits
Pleura
Punctures
Anesthetics
Analysis of Variance
Thorax
X-Rays

Keywords

  • Asymptomatic pneumothorax
  • Pneumothorax management
  • Supplemental oxygen
  • Traumatic pneumothorax

ASJC Scopus subject areas

  • Surgery

Cite this

Supplemental oxygen improves resolution of injury-induced pneumothorax. / Zierold, Dustin; Lee, Steven L.; Subramanian, Sreekumar -; Dubois, Jeffrey J.

In: Journal of Pediatric Surgery, Vol. 35, No. 6, 06.2000, p. 998-1001.

Research output: Contribution to journalArticle

Zierold, Dustin ; Lee, Steven L. ; Subramanian, Sreekumar - ; Dubois, Jeffrey J. / Supplemental oxygen improves resolution of injury-induced pneumothorax. In: Journal of Pediatric Surgery. 2000 ; Vol. 35, No. 6. pp. 998-1001.
@article{4ef3df39b70a4a18b6698b33b0c6e2f6,
title = "Supplemental oxygen improves resolution of injury-induced pneumothorax",
abstract = "Background/Purpose: Traditionally, supplemental oxygen is administered to patients with asymptomatic pneumothorax to accelerate spontaneous resolution. However, this practice is based on models that did not include injury to the visceral pleura and ongoing pleural air leak. This study evaluated the effects of increased inspired oxygen concentration on pneumothorax resolution in a visceral pleural injury model. Methods: A total of 27 New Zealand white rabbits were divided randomly into 3 groups: room air (RA), 40{\%} FIO 2 (40{\%}), and 60{\%} FIO 2 (60{\%}). A complete unilateral pneumothorax was created in each animal by a thoracoscopically guided visceral pleural puncture. The animals were then housed in designated oxygen chambers, and observers were blinded to the inspired oxygen concentration. Cross table anteroposterior chest x-rays were obtained preoperatively, postoperatively, and twice a day until the pneumothorax resolved. Time to resolution between the 3 groups was analyzed with 1-way analysis of variance (ANOVA). Results: Twenty of 27 (74{\%}) of the animals completed the study successfully. Mean time to resolution in the RA group (n = 7; 111.2 ± 30.8 hours) was longer than in the 40{\%} group (n = 6; 71.8 ± 22.3 hours) and the 60{\%} group (n=7; 39.4 ± 14.2 hours). The time to resolution also was longer in the 40{\%} group than in the 60{\%} group. Seven rabbits died before completion of the study of tension pneumothorax (3 of 7) or anesthetic complications (4 of 7). Conclusions: Supplemental oxygen improves resolution of injury-induced pneumothorax. The tradition of administering supplemental oxygen to patients with asymptomatic pneumothorax should be continued even if there is ongoing pleural air leak.",
keywords = "Asymptomatic pneumothorax, Pneumothorax management, Supplemental oxygen, Traumatic pneumothorax",
author = "Dustin Zierold and Lee, {Steven L.} and Subramanian, {Sreekumar -} and Dubois, {Jeffrey J.}",
year = "2000",
month = "6",
language = "English (US)",
volume = "35",
pages = "998--1001",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Supplemental oxygen improves resolution of injury-induced pneumothorax

AU - Zierold, Dustin

AU - Lee, Steven L.

AU - Subramanian, Sreekumar -

AU - Dubois, Jeffrey J.

PY - 2000/6

Y1 - 2000/6

N2 - Background/Purpose: Traditionally, supplemental oxygen is administered to patients with asymptomatic pneumothorax to accelerate spontaneous resolution. However, this practice is based on models that did not include injury to the visceral pleura and ongoing pleural air leak. This study evaluated the effects of increased inspired oxygen concentration on pneumothorax resolution in a visceral pleural injury model. Methods: A total of 27 New Zealand white rabbits were divided randomly into 3 groups: room air (RA), 40% FIO 2 (40%), and 60% FIO 2 (60%). A complete unilateral pneumothorax was created in each animal by a thoracoscopically guided visceral pleural puncture. The animals were then housed in designated oxygen chambers, and observers were blinded to the inspired oxygen concentration. Cross table anteroposterior chest x-rays were obtained preoperatively, postoperatively, and twice a day until the pneumothorax resolved. Time to resolution between the 3 groups was analyzed with 1-way analysis of variance (ANOVA). Results: Twenty of 27 (74%) of the animals completed the study successfully. Mean time to resolution in the RA group (n = 7; 111.2 ± 30.8 hours) was longer than in the 40% group (n = 6; 71.8 ± 22.3 hours) and the 60% group (n=7; 39.4 ± 14.2 hours). The time to resolution also was longer in the 40% group than in the 60% group. Seven rabbits died before completion of the study of tension pneumothorax (3 of 7) or anesthetic complications (4 of 7). Conclusions: Supplemental oxygen improves resolution of injury-induced pneumothorax. The tradition of administering supplemental oxygen to patients with asymptomatic pneumothorax should be continued even if there is ongoing pleural air leak.

AB - Background/Purpose: Traditionally, supplemental oxygen is administered to patients with asymptomatic pneumothorax to accelerate spontaneous resolution. However, this practice is based on models that did not include injury to the visceral pleura and ongoing pleural air leak. This study evaluated the effects of increased inspired oxygen concentration on pneumothorax resolution in a visceral pleural injury model. Methods: A total of 27 New Zealand white rabbits were divided randomly into 3 groups: room air (RA), 40% FIO 2 (40%), and 60% FIO 2 (60%). A complete unilateral pneumothorax was created in each animal by a thoracoscopically guided visceral pleural puncture. The animals were then housed in designated oxygen chambers, and observers were blinded to the inspired oxygen concentration. Cross table anteroposterior chest x-rays were obtained preoperatively, postoperatively, and twice a day until the pneumothorax resolved. Time to resolution between the 3 groups was analyzed with 1-way analysis of variance (ANOVA). Results: Twenty of 27 (74%) of the animals completed the study successfully. Mean time to resolution in the RA group (n = 7; 111.2 ± 30.8 hours) was longer than in the 40% group (n = 6; 71.8 ± 22.3 hours) and the 60% group (n=7; 39.4 ± 14.2 hours). The time to resolution also was longer in the 40% group than in the 60% group. Seven rabbits died before completion of the study of tension pneumothorax (3 of 7) or anesthetic complications (4 of 7). Conclusions: Supplemental oxygen improves resolution of injury-induced pneumothorax. The tradition of administering supplemental oxygen to patients with asymptomatic pneumothorax should be continued even if there is ongoing pleural air leak.

KW - Asymptomatic pneumothorax

KW - Pneumothorax management

KW - Supplemental oxygen

KW - Traumatic pneumothorax

UR - http://www.scopus.com/inward/record.url?scp=0034039505&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034039505&partnerID=8YFLogxK

M3 - Article

C2 - 10873053

AN - SCOPUS:0034039505

VL - 35

SP - 998

EP - 1001

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 6

ER -