Support vector machine for prediction of meiotic recombination hotspots and coldspots in Saccharomyces cerevisiae

Jianhong Weng, Tong Zhou, Xiao Sun, Zuhong Lu

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A method for predicting hotspots and coldspots using support vector machine (SVM) based on statistical learning theory is developed. This method is applied to published 303 hot and 48 cold open reading frames (ORFs) in Saccharomyces cerevisiae. The sequence features of general dinucleotide abundance and dinucleotide abundance based on codon usage are extracted, and then the data sets are classified with different parameters and kernel functions combined with the method of two-fold cross validation. The result indicates that 87.47% accuracy can be reached when classifying hot and cold ORF sequences with the kernel of radial basis function combined with dinucleotide abundance based on codon usage.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalJournal of Southeast University (English Edition)
Volume22
Issue number1
StatePublished - Mar 1 2006

Keywords

  • Coldspot
  • Dinucleotide abundance
  • Hotspot
  • Meiotic recombination
  • Support vector machine

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Support vector machine for prediction of meiotic recombination hotspots and coldspots in Saccharomyces cerevisiae'. Together they form a unique fingerprint.

  • Cite this