Suppression of hippocampal synaptic plasticity during slow-wave sleep

B. Jones Leonard, B. L. McNaughton, C. A. Barnes

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

The influence of behavioral state on the induction of long-term enhancement (LTE) of hippocampal synapses was studied in chronically prepared animals. Perforant path evoked field potentials and EEG were recorded from fascia dentata during slow-wave sleep (SWS) and waking. LTE was strongly suppressed during SWS, suggesting that hippocampal information storage may be inactivated at certain phases of the sleep cycle. Normal LTE was observed in the same animals while awake.

Original languageEnglish (US)
Pages (from-to)174-177
Number of pages4
JournalBrain Research
Volume425
Issue number1
DOIs
StatePublished - Nov 3 1987
Externally publishedYes

Keywords

  • (LTP)
  • Behavioral state
  • Field potential
  • Hippocampus
  • Learning
  • Long-term potentiation
  • Long-term synaptic enhancement
  • Memory
  • Sleep

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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