Suppression of tissue levels of vitamin A, E, zinc and copper in murine aids

Yuejian Wang, Bailin Liang, Ronald R Watson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Female C57BL/6 mice were infected with LP-BM5 retrovirus, causing murine acquired immune deficiency syndrome (MAIDS) which is functionally similar to human AIDS. Because human immunodeficiency virus may compromise nutritional status and nutritional disorders have been found in AIDS patients, the influence of murine retrovirus infection on levels of important immune-related nutrients (vitamin A, E, zinc and copper) in the serum, liver, small intestine, spleen and thymus was determined in MAIDS. The levels of vitamin A, E and copper in the liver in MAIDS were significantly reduced compared to controls, whereas the level of zinc in the liver was not affected. Intestinal level of vitamin A was significantly reduced by retrovirus infection, whereas copper level in the small intestine was significantly increased compared to controls. Intestinal levels of zinc and vitamin E were not affected. The levels of vitamin A, E and zinc in the spleen in murine AIDS were significantly rebared compared to controls, whereas the splenic level of copper was not influenced. The levels of vitamin A, E and copper in the thymus in MAIDS were significantly lessened by retrovirus infection compared to controls, whereas thymic level of zinc was significantly elevated. The levels of vitamin A and E in the serum in MAIDS were significantly decreased by retrovirus infection compared to controls. The data indicated that retrovirus infection can directly cause malnutrition, possible via damaging gastrointestinal cells, thereby leading to malabsorption. Such malnutrition has the theoretical potential to accelerate development of AIDS via immunosuppression secondary to nutritional deficiency.

Original languageEnglish (US)
Pages (from-to)1031-1041
Number of pages11
JournalNutrition Research
Volume14
Issue number7
DOIs
StatePublished - 1994

Fingerprint

Murine Acquired Immunodeficiency Syndrome
Retroviridae Infections
Vitamin A
Vitamin E
Zinc
Copper
Malnutrition
Acquired Immunodeficiency Syndrome
Thymus Gland
Small Intestine
Liver
Spleen
Nutrition Disorders
Retroviridae
Nutritional Status
Serum
Inbred C57BL Mouse
Immunosuppression
HIV
Food

Keywords

  • Copper
  • Malnutrition
  • Murine AIDS
  • Vitamin A and E
  • Zinc

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Suppression of tissue levels of vitamin A, E, zinc and copper in murine aids. / Wang, Yuejian; Liang, Bailin; Watson, Ronald R.

In: Nutrition Research, Vol. 14, No. 7, 1994, p. 1031-1041.

Research output: Contribution to journalArticle

Wang, Yuejian ; Liang, Bailin ; Watson, Ronald R. / Suppression of tissue levels of vitamin A, E, zinc and copper in murine aids. In: Nutrition Research. 1994 ; Vol. 14, No. 7. pp. 1031-1041.
@article{e74358224e6949cc86c8f58af9b8c7ad,
title = "Suppression of tissue levels of vitamin A, E, zinc and copper in murine aids",
abstract = "Female C57BL/6 mice were infected with LP-BM5 retrovirus, causing murine acquired immune deficiency syndrome (MAIDS) which is functionally similar to human AIDS. Because human immunodeficiency virus may compromise nutritional status and nutritional disorders have been found in AIDS patients, the influence of murine retrovirus infection on levels of important immune-related nutrients (vitamin A, E, zinc and copper) in the serum, liver, small intestine, spleen and thymus was determined in MAIDS. The levels of vitamin A, E and copper in the liver in MAIDS were significantly reduced compared to controls, whereas the level of zinc in the liver was not affected. Intestinal level of vitamin A was significantly reduced by retrovirus infection, whereas copper level in the small intestine was significantly increased compared to controls. Intestinal levels of zinc and vitamin E were not affected. The levels of vitamin A, E and zinc in the spleen in murine AIDS were significantly rebared compared to controls, whereas the splenic level of copper was not influenced. The levels of vitamin A, E and copper in the thymus in MAIDS were significantly lessened by retrovirus infection compared to controls, whereas thymic level of zinc was significantly elevated. The levels of vitamin A and E in the serum in MAIDS were significantly decreased by retrovirus infection compared to controls. The data indicated that retrovirus infection can directly cause malnutrition, possible via damaging gastrointestinal cells, thereby leading to malabsorption. Such malnutrition has the theoretical potential to accelerate development of AIDS via immunosuppression secondary to nutritional deficiency.",
keywords = "Copper, Malnutrition, Murine AIDS, Vitamin A and E, Zinc",
author = "Yuejian Wang and Bailin Liang and Watson, {Ronald R}",
year = "1994",
doi = "10.1016/S0271-5317(05)80257-X",
language = "English (US)",
volume = "14",
pages = "1031--1041",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Suppression of tissue levels of vitamin A, E, zinc and copper in murine aids

AU - Wang, Yuejian

AU - Liang, Bailin

AU - Watson, Ronald R

PY - 1994

Y1 - 1994

N2 - Female C57BL/6 mice were infected with LP-BM5 retrovirus, causing murine acquired immune deficiency syndrome (MAIDS) which is functionally similar to human AIDS. Because human immunodeficiency virus may compromise nutritional status and nutritional disorders have been found in AIDS patients, the influence of murine retrovirus infection on levels of important immune-related nutrients (vitamin A, E, zinc and copper) in the serum, liver, small intestine, spleen and thymus was determined in MAIDS. The levels of vitamin A, E and copper in the liver in MAIDS were significantly reduced compared to controls, whereas the level of zinc in the liver was not affected. Intestinal level of vitamin A was significantly reduced by retrovirus infection, whereas copper level in the small intestine was significantly increased compared to controls. Intestinal levels of zinc and vitamin E were not affected. The levels of vitamin A, E and zinc in the spleen in murine AIDS were significantly rebared compared to controls, whereas the splenic level of copper was not influenced. The levels of vitamin A, E and copper in the thymus in MAIDS were significantly lessened by retrovirus infection compared to controls, whereas thymic level of zinc was significantly elevated. The levels of vitamin A and E in the serum in MAIDS were significantly decreased by retrovirus infection compared to controls. The data indicated that retrovirus infection can directly cause malnutrition, possible via damaging gastrointestinal cells, thereby leading to malabsorption. Such malnutrition has the theoretical potential to accelerate development of AIDS via immunosuppression secondary to nutritional deficiency.

AB - Female C57BL/6 mice were infected with LP-BM5 retrovirus, causing murine acquired immune deficiency syndrome (MAIDS) which is functionally similar to human AIDS. Because human immunodeficiency virus may compromise nutritional status and nutritional disorders have been found in AIDS patients, the influence of murine retrovirus infection on levels of important immune-related nutrients (vitamin A, E, zinc and copper) in the serum, liver, small intestine, spleen and thymus was determined in MAIDS. The levels of vitamin A, E and copper in the liver in MAIDS were significantly reduced compared to controls, whereas the level of zinc in the liver was not affected. Intestinal level of vitamin A was significantly reduced by retrovirus infection, whereas copper level in the small intestine was significantly increased compared to controls. Intestinal levels of zinc and vitamin E were not affected. The levels of vitamin A, E and zinc in the spleen in murine AIDS were significantly rebared compared to controls, whereas the splenic level of copper was not influenced. The levels of vitamin A, E and copper in the thymus in MAIDS were significantly lessened by retrovirus infection compared to controls, whereas thymic level of zinc was significantly elevated. The levels of vitamin A and E in the serum in MAIDS were significantly decreased by retrovirus infection compared to controls. The data indicated that retrovirus infection can directly cause malnutrition, possible via damaging gastrointestinal cells, thereby leading to malabsorption. Such malnutrition has the theoretical potential to accelerate development of AIDS via immunosuppression secondary to nutritional deficiency.

KW - Copper

KW - Malnutrition

KW - Murine AIDS

KW - Vitamin A and E

KW - Zinc

UR - http://www.scopus.com/inward/record.url?scp=0028232940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028232940&partnerID=8YFLogxK

U2 - 10.1016/S0271-5317(05)80257-X

DO - 10.1016/S0271-5317(05)80257-X

M3 - Article

AN - SCOPUS:0028232940

VL - 14

SP - 1031

EP - 1041

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 7

ER -