Surface activation of blood coagulation, fibrinolysis and kinin formation

Ronald L Heimark, Kotoku Kurachi, Kazuo Fujikawa, Earl W. Davie

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

The activation of plasma prekallikrein by single-chain factor XII has been studied in the presence of high molecular weight kininogen and kaolin. The data indicate that factor XII can initiate blood coagulation, fibrinolysis or kinin generation in the presence of kaolin and does so by converting prekallikrein to kallikrein. An enzyme cascade is then generated leading to the formation of fibrin, plasmin or bradykinin in three closely related physiological events.

Original languageEnglish (US)
Pages (from-to)456-460
Number of pages5
JournalNature
Volume286
Issue number5772
DOIs
StatePublished - 1980
Externally publishedYes

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Prekallikrein
Factor XII
Kaolin
Kinins
Blood Coagulation
Fibrinolysis
High Molecular Weight Kininogens
Kallikreins
Fibrinolysin
Bradykinin
Fibrin
Enzymes

ASJC Scopus subject areas

  • General

Cite this

Surface activation of blood coagulation, fibrinolysis and kinin formation. / Heimark, Ronald L; Kurachi, Kotoku; Fujikawa, Kazuo; Davie, Earl W.

In: Nature, Vol. 286, No. 5772, 1980, p. 456-460.

Research output: Contribution to journalArticle

Heimark, RL, Kurachi, K, Fujikawa, K & Davie, EW 1980, 'Surface activation of blood coagulation, fibrinolysis and kinin formation', Nature, vol. 286, no. 5772, pp. 456-460. https://doi.org/10.1038/286456a0
Heimark, Ronald L ; Kurachi, Kotoku ; Fujikawa, Kazuo ; Davie, Earl W. / Surface activation of blood coagulation, fibrinolysis and kinin formation. In: Nature. 1980 ; Vol. 286, No. 5772. pp. 456-460.
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