Surface analytical techniques in solid-state particle characterization for predicting performance in dry powder inhalers

Xiao Wu, Xiaojian Li, Heidi - Mansour

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The pulmonary route is of interest for both ef fective local therapy for respiratory and lung diseases, such as asthma, chronic obstructive pulmonary disease and cystic fibrosis, and systemic administration of drugs, such as proteins and peptides. Dry powder inhalers (DPIs) are devices through which a dry powder formulation of drug is delivered via the pulmonary route. The DPIs are highly efficient but complicated systems, the performance of which relies on many aspects, including aerodynamic diameter of the powder formulation, particle density, bulk density, surface morphology and composition, particle shape, interparticulate cohesive forces between drug particles and interparticulate adhesive forces between drug and carrier particles. Among them, surface morphology of both drug particles and carrier particles within the formulation is a very important factor in determining the interparticulate contact area and forces, aerosolization efficiency and subsequent lung deposition. Techniques that have been applied to study surface properties of solidstate particles in DPIs include atomic force microscopy, micro-and nanothermal analysis, inverse gas chromatography and X-ray photoelectron spectroscopy. This paper reviews different aspects of DPIs, with emphasis on their surface properties and influence on aerosol performance, and the techniques that are utilized to examine their surface properties.

Original languageEnglish (US)
Pages (from-to)3-19
Number of pages17
JournalKONA Powder and Particle Journal
Volume28
StatePublished - 2010
Externally publishedYes

Fingerprint

Powders
Pulmonary diseases
Surface properties
Pharmaceutical Preparations
Surface morphology
Drug Carriers
Aerosols
Surface structure
Gas chromatography
Peptides
Atomic force microscopy
Adhesives
Aerodynamics
X ray photoelectron spectroscopy
Proteins

Keywords

  • Inhalation aerosols
  • Interparticulate forces
  • Particle engineering
  • Pharmaceutical powders
  • Pulmonary drug delivery
  • Surface chemistry

ASJC Scopus subject areas

  • Materials Science(all)
  • Chemical Engineering(all)
  • Chemistry(all)
  • Engineering(all)

Cite this

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abstract = "The pulmonary route is of interest for both ef fective local therapy for respiratory and lung diseases, such as asthma, chronic obstructive pulmonary disease and cystic fibrosis, and systemic administration of drugs, such as proteins and peptides. Dry powder inhalers (DPIs) are devices through which a dry powder formulation of drug is delivered via the pulmonary route. The DPIs are highly efficient but complicated systems, the performance of which relies on many aspects, including aerodynamic diameter of the powder formulation, particle density, bulk density, surface morphology and composition, particle shape, interparticulate cohesive forces between drug particles and interparticulate adhesive forces between drug and carrier particles. Among them, surface morphology of both drug particles and carrier particles within the formulation is a very important factor in determining the interparticulate contact area and forces, aerosolization efficiency and subsequent lung deposition. Techniques that have been applied to study surface properties of solidstate particles in DPIs include atomic force microscopy, micro-and nanothermal analysis, inverse gas chromatography and X-ray photoelectron spectroscopy. This paper reviews different aspects of DPIs, with emphasis on their surface properties and influence on aerosol performance, and the techniques that are utilized to examine their surface properties.",
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AU - Li, Xiaojian

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N2 - The pulmonary route is of interest for both ef fective local therapy for respiratory and lung diseases, such as asthma, chronic obstructive pulmonary disease and cystic fibrosis, and systemic administration of drugs, such as proteins and peptides. Dry powder inhalers (DPIs) are devices through which a dry powder formulation of drug is delivered via the pulmonary route. The DPIs are highly efficient but complicated systems, the performance of which relies on many aspects, including aerodynamic diameter of the powder formulation, particle density, bulk density, surface morphology and composition, particle shape, interparticulate cohesive forces between drug particles and interparticulate adhesive forces between drug and carrier particles. Among them, surface morphology of both drug particles and carrier particles within the formulation is a very important factor in determining the interparticulate contact area and forces, aerosolization efficiency and subsequent lung deposition. Techniques that have been applied to study surface properties of solidstate particles in DPIs include atomic force microscopy, micro-and nanothermal analysis, inverse gas chromatography and X-ray photoelectron spectroscopy. This paper reviews different aspects of DPIs, with emphasis on their surface properties and influence on aerosol performance, and the techniques that are utilized to examine their surface properties.

AB - The pulmonary route is of interest for both ef fective local therapy for respiratory and lung diseases, such as asthma, chronic obstructive pulmonary disease and cystic fibrosis, and systemic administration of drugs, such as proteins and peptides. Dry powder inhalers (DPIs) are devices through which a dry powder formulation of drug is delivered via the pulmonary route. The DPIs are highly efficient but complicated systems, the performance of which relies on many aspects, including aerodynamic diameter of the powder formulation, particle density, bulk density, surface morphology and composition, particle shape, interparticulate cohesive forces between drug particles and interparticulate adhesive forces between drug and carrier particles. Among them, surface morphology of both drug particles and carrier particles within the formulation is a very important factor in determining the interparticulate contact area and forces, aerosolization efficiency and subsequent lung deposition. Techniques that have been applied to study surface properties of solidstate particles in DPIs include atomic force microscopy, micro-and nanothermal analysis, inverse gas chromatography and X-ray photoelectron spectroscopy. This paper reviews different aspects of DPIs, with emphasis on their surface properties and influence on aerosol performance, and the techniques that are utilized to examine their surface properties.

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KW - Interparticulate forces

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KW - Pharmaceutical powders

KW - Pulmonary drug delivery

KW - Surface chemistry

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