Survival after myocardial infarction in rats: Captopril versus losartan

James J. Milavetz, Thomas E. Raya, Cynthia S. Johnson, Eugene Morkin, Steven Goldman

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Abstract

Objectives. This study sought to compare the effects of angiotensin-converting enzyme inhibition versus angiotensin II receptor blockade on survival in rats with myocardial infarction. Background. The effects of specific nonpeptide angiotensin receptor blocking agents on survival after myocardial infarction are unknown. Methods. Rats with a moderate to large myocardial infarction were treated with captopril (2 g/liter drinking water, n = 87) or losartan (2 g/liter drinking water, n = 96). Therapy was initiated immediately after coronary artery ligation and continued for 1 year. Results. Uncensored median survival in captopril-treated rats that survived at least 48 h was 201.5 days versus 236.0 days for losartan-treated rats (p = 0.066). Median survival censored for rats with lung infections was 201.5 days in captopril-treated rats versus 243.0 days for losartan-treated rats (p = 0.028). Conscious hemodynamic measurements and remodeling data obtained at 1 year in the surviving rats (n = 5 for captopril; n = 9 for losartan) revealed no differences in heart weight, left ventricular pressure, dP/dt, cardiac index, time constant of relaxation or any variable of left ventricular remodeling. The only differences (mean ± SD) were an increase in heart rate (293 ± 19 vs. 266 ± 15 beats/min, p < 0.05) and a decrease in peak developed pressure (153 ± 21 vs. 180 ± 16 mm Hg, p < 0.05) in the losartan-treated rats. Conclusions. We conclude that in this experimental model of heart failure, there was no difference betweeen survival after angiotensin II receptor blockade with losartan and with angiotensin-converting enzyme inhibition with captopril.

Original languageEnglish (US)
Pages (from-to)714-719
Number of pages6
JournalJournal of the American College of Cardiology
Volume27
Issue number3
DOIs
StatePublished - Mar 1 1996

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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