Survival in Patients with Advanced Non-cystic Fibrosis Bronchiectasis Versus Cystic Fibrosis on the Waitlist for Lung Transplantation

Don Hayes, Benjamin T. Kopp, Joseph D. Tobias, Frederick W. Woodley, Heidi - Mansour, Dmitry Tumin, Stephen E. Kirkby

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Survival in non-cystic fibrosis (CF) bronchiectasis is not well studied. Methods: The United Network for Organ Sharing database was queried from 1987 to 2013 to compare survival in adult patients with non-CF bronchiectasis to patients with CF listed for lung transplantation (LTx). Each subject was tracked from waitlist entry date until death or censoring to determine survival differences between the two groups. Results: Of 2112 listed lung transplant candidates with bronchiectasis (180 non-CF, 1932 CF), 1617 were used for univariate Cox and Kaplan–Meier survival function analysis, 1173 for multivariate Cox models, and 182 for matched-pairs analysis based on propensity scores. Compared to CF, patients with non-CF bronchiectasis had a significantly lower mortality by univariate Cox analysis (HR 0.565; 95 % CI 0.424, 0.754; p 

Original languageEnglish (US)
Pages (from-to)933-938
Number of pages6
JournalLung
Volume193
Issue number6
DOIs
StatePublished - Dec 1 2015

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Keywords

  • Bronchiectasis
  • Cystic fibrosis
  • Non-cystic fibrosis
  • Survival

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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