Symptom experience associated with maintenance immunosuppression after heart transplantation

Patients' appraisal of side effects

Philip Moons, Sabina De Geest, Ivo L Abraham, Johan Van Cleemput, Johan Vanhaecke

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate symptom experience related to side effects of immunosuppressive therapy in heart transplant recipients. METHODS: This descriptive, cross-sectional study included 105 heart transplant recipients (90 men; 15 women) with a median age of 56 years. Maintenance immunosuppression consisted of triple therapy (cyclosporine, corticosteroids, azathioprine). Symptom frequency and symptom distress were assessed by an adapted version of the Transplant Symptom Frequency and Symptom Distress Scale, which includes 27 symptoms associated with side effects of immunosuppressive therapy. RESULTS: The most frequent symptom for both sexes was increased hair growth. Impotence and painful menstruation were experienced as the most distressing symptoms for men and women, respectively. Women reported a significantly higher level of symptom experience. The majority of the most frequent and most distressing symptoms were corticosteroid associated. CONCLUSIONS: Patients' Perception of side effects completes the symptomatologic profile of immunosuppressive therapy. A gender- specific evaluation is indicated because symptom experience differs between the sexes.

Original languageEnglish (US)
Pages (from-to)315-325
Number of pages11
JournalHeart and Lung: Journal of Acute and Critical Care
Volume27
Issue number5
DOIs
StatePublished - Sep 1998
Externally publishedYes

Fingerprint

Heart Transplantation
Immunosuppression
Immunosuppressive Agents
Maintenance
Adrenal Cortex Hormones
Dysmenorrhea
Azathioprine
Erectile Dysfunction
Therapeutics
Hair
Cyclosporine
Cross-Sectional Studies
Transplants
Growth
Transplant Recipients

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Critical Care and Intensive Care Medicine
  • Pulmonary and Respiratory Medicine

Cite this

Symptom experience associated with maintenance immunosuppression after heart transplantation : Patients' appraisal of side effects. / Moons, Philip; De Geest, Sabina; Abraham, Ivo L; Van Cleemput, Johan; Vanhaecke, Johan.

In: Heart and Lung: Journal of Acute and Critical Care, Vol. 27, No. 5, 09.1998, p. 315-325.

Research output: Contribution to journalArticle

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