Synaptic clusters function as odor operators in the olfactory bulb

Michele Migliore, Francesco Cavarretta, Addolorata Marasco, Eleonora Tulumello, Michael L. Hines, Gordon M. Shepherd, John G Hildebrand

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

How the olfactory bulb organizes and processes odor inputs through fundamental operations of its microcircuits is largely unknown. To gain new insight we focus on odor-activated synaptic clusters related to individual glomeruli, which we call glomerular units. Using a 3Dmodel of mitral and granule cell interactions supported by experimental findings, combined with a matrix-based representation of glomerular operations, we identify the mechanisms for forming one or more glomerular units in response to a given odor, how and to what extent the glomerular units interfere or interact with each other during learning, their computational role within the olfactory bulb microcircuit, and how their actions can be formalized into a theoretical framework in which the olfactory bulb can be considered to contain "odor operators" unique to each individual. The results provide new and specific theoretical and experimentally testable predictions.

Original languageEnglish (US)
Pages (from-to)8499-8504
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number27
DOIs
StatePublished - Jul 7 2015

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Olfactory Bulb
Cell Communication
Learning
Odorants

Keywords

  • Granule cells
  • Mitral cells
  • Network self-organization
  • Odor coding
  • Olfactory bulb system

ASJC Scopus subject areas

  • General

Cite this

Synaptic clusters function as odor operators in the olfactory bulb. / Migliore, Michele; Cavarretta, Francesco; Marasco, Addolorata; Tulumello, Eleonora; Hines, Michael L.; Shepherd, Gordon M.; Hildebrand, John G.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 27, 07.07.2015, p. 8499-8504.

Research output: Contribution to journalArticle

Migliore, Michele ; Cavarretta, Francesco ; Marasco, Addolorata ; Tulumello, Eleonora ; Hines, Michael L. ; Shepherd, Gordon M. ; Hildebrand, John G. / Synaptic clusters function as odor operators in the olfactory bulb. In: Proceedings of the National Academy of Sciences of the United States of America. 2015 ; Vol. 112, No. 27. pp. 8499-8504.
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