Synaptic dynamics at the neuromuscular junction

Mechanisms and models

D. C. Van Essen, Herman Gordon, J. M. Soha, S. E. Fraser

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

During development, the neuromuscular junction passes through a stage of extensive polyinnervation followed by a period of wholesale synapse elimination. In this report we discuss mechanisms and interactions that could mediate many of the key aspects of these important developmental events. Our emphasis is on (1) establishing an overall conceptual framework within which the role of many distinct cellular interactions and molecular factors can be evaluated, and (2) generating computer simulations that systematically test the adequacy of different models in accounting for a wide range of biological data. Our analysis indicates that several relatively simple mechanisms are each capable of explaining a variety of experimental observations. On the other hand, no one mechanism can account for the full spectrum of experimental results. Thus, it is important to consider models that are based on interactions among multiple mechanisms. A potentially powerful combination is one based on (1) a scaffold wthin the basal lamina or in the post-synaptic membrane which is induced by nerve terminals and which serves to stabilize terminals by a positive feedback mechanism; (2) a sprouting factor whose release by muscle fibers is down-regulated by activity and perhaps other factors; and (3) an intrinsic tendency of motor neurons to withdraw some connections while allowing others to grow.

Original languageEnglish (US)
Pages (from-to)223-249
Number of pages27
JournalJournal of Neurobiology
Volume21
Issue number1
StatePublished - 1990
Externally publishedYes

Fingerprint

Synaptic Membranes
Neuromuscular Junction
Motor Neurons
Basement Membrane
Computer Simulation
Synapses
Muscles

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Van Essen, D. C., Gordon, H., Soha, J. M., & Fraser, S. E. (1990). Synaptic dynamics at the neuromuscular junction: Mechanisms and models. Journal of Neurobiology, 21(1), 223-249.

Synaptic dynamics at the neuromuscular junction : Mechanisms and models. / Van Essen, D. C.; Gordon, Herman; Soha, J. M.; Fraser, S. E.

In: Journal of Neurobiology, Vol. 21, No. 1, 1990, p. 223-249.

Research output: Contribution to journalArticle

Van Essen, DC, Gordon, H, Soha, JM & Fraser, SE 1990, 'Synaptic dynamics at the neuromuscular junction: Mechanisms and models', Journal of Neurobiology, vol. 21, no. 1, pp. 223-249.
Van Essen, D. C. ; Gordon, Herman ; Soha, J. M. ; Fraser, S. E. / Synaptic dynamics at the neuromuscular junction : Mechanisms and models. In: Journal of Neurobiology. 1990 ; Vol. 21, No. 1. pp. 223-249.
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