Syndrome of inappropriate antidiuretic hormone secretion caused by high-dose bolus interleukin-2 therapy for metastatic melanoma

Myke R. Green, Joseph E. Woolery, Emad Elquza

Research output: Contribution to journalArticle

4 Scopus citations


Melanoma is a relatively common cancer and is often associated with a dire prognosis once diagnosed as metastatic. Immunomodulatory therapy with high-dose bolus interleukin-2 may provide durable responses, albeit in a small subset of those afflicted with metastatic melanoma. High-dose interleukin-2 is well-known to cause substantial toxicities, both acute and delayed. We report on a single case of syndrome of inappropriate antidiuretic hormone secretion in a patient with metastatic melanoma with metastases to the lung and liver which was associated with high-dose bolus interleukin-2 therapy.

Original languageEnglish (US)
Pages (from-to)e159-e161
JournalAmerican journal of therapeutics
Issue number5
StatePublished - Sep 1 2011



  • interleukin-2
  • melanoma
  • syndrome of inappropriate antidiuretic hormone

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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