Synonymous codon usage in genes coding for proteins with different folding types

Wanjun Gu, Jianmin Ma, Tong Zhou, Xiao Sun, Zuhong Lu

Research output: Contribution to journalConference article

Abstract

195 genes coding for proteins in four different folding types have been analyzed in terms of variance analysis, in which there are 50 genes coding for all alpha proteins, 66 entries for all beta proteins, 37 entries for alpha+beta proteins and 42 entries for alpha/beta proteins. We have observed that codon usage in different gene classes coding for differently folded proteins is significantly different. Similar to amino acid propensities in different protein classes, folding type specific proteins have specific codon usage patterns. With the help of codon usage pattern, we can improve the accuracy of prediction of protein folding type and further prediction of protein secondary structure.

Original languageEnglish (US)
Pages (from-to)2202-2203
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume3
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Protein folding type
  • Protein secondary structure prediction
  • Synonymous codon usage
  • Variance analysis

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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