Syntactic processing depends on dorsal language tracts

Stephen M Wilson, Sebastiano Galantucci, Maria Carmela Tartaglia, Kindle Rising, Dianne K. Patterson, Maya L. Henry, Jennifer M. Ogar, Jessica DeLeon, Bruce L. Miller, Maria Luisa Gorno-Tempini

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Frontal and temporal language areas involved in syntactic processing are connected by several dorsal and ventral tracts, but the functional roles of the different tracts are not well understood. To identify which white matter tract(s) are important for syntactic processing, we examined the relationship between white matter damage and syntactic deficits in patients with primary progressive aphasia, using multimodal neuroimaging and neurolinguistic assessment. Diffusion tensor imaging showed that microstructural damage to left hemisphere dorsal tracts-the superior longitudinal fasciculus including its arcuate component-was strongly associated with deficits in comprehension and production of syntax. Damage to these dorsal tracts predicted syntactic deficits after gray matter atrophy was taken into account, and fMRI confirmed that these tracts connect regions modulated by syntactic processing. In contrast, damage to ventral tracts-the extreme capsule fiber system or the uncinate fasciculus-was not associated with syntactic deficits. Our findings show that syntactic processing depends primarily on dorsal language tracts.

Original languageEnglish (US)
Pages (from-to)397-403
Number of pages7
JournalNeuron
Volume72
Issue number2
DOIs
StatePublished - Oct 20 2011

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Language
Primary Progressive Aphasia
Diffusion Tensor Imaging
Neuroimaging
Atrophy
Capsules
Magnetic Resonance Imaging
White Matter
Gray Matter

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wilson, S. M., Galantucci, S., Tartaglia, M. C., Rising, K., Patterson, D. K., Henry, M. L., ... Gorno-Tempini, M. L. (2011). Syntactic processing depends on dorsal language tracts. Neuron, 72(2), 397-403. https://doi.org/10.1016/j.neuron.2011.09.014

Syntactic processing depends on dorsal language tracts. / Wilson, Stephen M; Galantucci, Sebastiano; Tartaglia, Maria Carmela; Rising, Kindle; Patterson, Dianne K.; Henry, Maya L.; Ogar, Jennifer M.; DeLeon, Jessica; Miller, Bruce L.; Gorno-Tempini, Maria Luisa.

In: Neuron, Vol. 72, No. 2, 20.10.2011, p. 397-403.

Research output: Contribution to journalArticle

Wilson, SM, Galantucci, S, Tartaglia, MC, Rising, K, Patterson, DK, Henry, ML, Ogar, JM, DeLeon, J, Miller, BL & Gorno-Tempini, ML 2011, 'Syntactic processing depends on dorsal language tracts', Neuron, vol. 72, no. 2, pp. 397-403. https://doi.org/10.1016/j.neuron.2011.09.014
Wilson SM, Galantucci S, Tartaglia MC, Rising K, Patterson DK, Henry ML et al. Syntactic processing depends on dorsal language tracts. Neuron. 2011 Oct 20;72(2):397-403. https://doi.org/10.1016/j.neuron.2011.09.014
Wilson, Stephen M ; Galantucci, Sebastiano ; Tartaglia, Maria Carmela ; Rising, Kindle ; Patterson, Dianne K. ; Henry, Maya L. ; Ogar, Jennifer M. ; DeLeon, Jessica ; Miller, Bruce L. ; Gorno-Tempini, Maria Luisa. / Syntactic processing depends on dorsal language tracts. In: Neuron. 2011 ; Vol. 72, No. 2. pp. 397-403.
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