Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-Amino-3, 3-diarylpropionic acids

J. Lin, S. Liao, V. J. Hruby

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A series of optically pure, conformationally constrained, and highly hydrophobic unusual aromatic amino acids, 2-amino-3,3-diarylpropionic acids, were synthesized via asymmetric 1,4-Michael addition reaction/azidation reactions in seven steps with overall yields of 20-30%.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalJournal of Peptide Research
Volume65
Issue number1
DOIs
StatePublished - Jan 1 2005

Keywords

  • Aromatic amino acids
  • Asymmetric synthesis
  • Conformationally constrained amino acids

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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