Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid

Y. Hu, Emmanuelle Meuillet, L. Qiao, M. M. Berggren, G. Powis, A. P. Kozikowski

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

1D-3,4-Dideoxyphosphatidylinositol ether lipid 2, a PI analog, was synthesized through a sequence of protection/deprotection protocols and two Barton deoxygenation reactions, starting from L-(-)-quebrachitol. DDPIEL is 18-fold more potent than its monodeoxy counterpart DPIEL in the inhibition of PI3-K. (C) 2000 Published by Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)7415-7418
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number39
StatePublished - Sep 23 2000

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Ether
Lipids
quebrachitol

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Hu, Y., Meuillet, E., Qiao, L., Berggren, M. M., Powis, G., & Kozikowski, A. P. (2000). Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid. Tetrahedron Letters, 41(39), 7415-7418.

Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid. / Hu, Y.; Meuillet, Emmanuelle; Qiao, L.; Berggren, M. M.; Powis, G.; Kozikowski, A. P.

In: Tetrahedron Letters, Vol. 41, No. 39, 23.09.2000, p. 7415-7418.

Research output: Contribution to journalArticle

Hu, Y, Meuillet, E, Qiao, L, Berggren, MM, Powis, G & Kozikowski, AP 2000, 'Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid', Tetrahedron Letters, vol. 41, no. 39, pp. 7415-7418.
Hu Y, Meuillet E, Qiao L, Berggren MM, Powis G, Kozikowski AP. Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid. Tetrahedron Letters. 2000 Sep 23;41(39):7415-7418.
Hu, Y. ; Meuillet, Emmanuelle ; Qiao, L. ; Berggren, M. M. ; Powis, G. ; Kozikowski, A. P. / Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid. In: Tetrahedron Letters. 2000 ; Vol. 41, No. 39. pp. 7415-7418.
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