Synthesis and Akt inhibitory properties of a 1D-3,4-dideoxyphosphatidylinositol ether lipid

Youhong Hu, Emmanuelle J. Meuillet, Lixin Qiao, Margaret M. Berggren, Garth Powis, Alan P. Kozikowski

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

1D-3,4-Dideoxyphosphatidylinositol ether lipid 2, a PI analog, was synthesized through a sequence of protection/deprotection protocols and two Barton deoxygenation reactions, starting from L-(-)-quebrachitol. DDPIEL is 18-fold more potent than its monodeoxy counterpart DPIEL in the inhibition of PI3-K.

Original languageEnglish (US)
Pages (from-to)7415-7418
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number39
DOIs
StatePublished - Sep 23 2000

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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