Synthesis and biological activity of analogs of fecapentaene-12

S. V. Govindan, David G I Kingston, Leslie Gunatilaka, Roger L. Van Tassell, Tracy D. Wilkins, P. P. De Wit, M. Van Der Steeg, A. Van Der Gen

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Analogs of the potent fecal mutagen fecapentaene-12 [1] have been prepared and tested both for mutagenicity and for their ability to serve as biological precursors of 1. It was found that mutagenicity in three different Salmonella tester strains TA96, TA100, and TA104, decreased rapidly as the number of conjugated double bonds was reduced. The aldehyde 8, analogous to the hydrolysis product of 1, showed only low mutagenicity, even in the aldehyde-sensitive strain TA104. None of the polyenes prepared was able to function as a direct biological precursor of of 1 under the conditions employed.

Original languageEnglish (US)
Pages (from-to)75-83
Number of pages9
JournalJournal of Natural Products
Volume50
Issue number1
StatePublished - 1987
Externally publishedYes

Fingerprint

mutagenicity
Bioactivity
Aldehydes
bioactive properties
Polyenes
aldehydes
Salmonella
synthesis
Mutagens
Hydrolysis
hydrolysis
1-(1-glycero)dodeca-1,3,5,7,9-pentaene

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Govindan, S. V., Kingston, D. G. I., Gunatilaka, L., Van Tassell, R. L., Wilkins, T. D., De Wit, P. P., ... Van Der Gen, A. (1987). Synthesis and biological activity of analogs of fecapentaene-12. Journal of Natural Products, 50(1), 75-83.

Synthesis and biological activity of analogs of fecapentaene-12. / Govindan, S. V.; Kingston, David G I; Gunatilaka, Leslie; Van Tassell, Roger L.; Wilkins, Tracy D.; De Wit, P. P.; Van Der Steeg, M.; Van Der Gen, A.

In: Journal of Natural Products, Vol. 50, No. 1, 1987, p. 75-83.

Research output: Contribution to journalArticle

Govindan, SV, Kingston, DGI, Gunatilaka, L, Van Tassell, RL, Wilkins, TD, De Wit, PP, Van Der Steeg, M & Van Der Gen, A 1987, 'Synthesis and biological activity of analogs of fecapentaene-12', Journal of Natural Products, vol. 50, no. 1, pp. 75-83.
Govindan SV, Kingston DGI, Gunatilaka L, Van Tassell RL, Wilkins TD, De Wit PP et al. Synthesis and biological activity of analogs of fecapentaene-12. Journal of Natural Products. 1987;50(1):75-83.
Govindan, S. V. ; Kingston, David G I ; Gunatilaka, Leslie ; Van Tassell, Roger L. ; Wilkins, Tracy D. ; De Wit, P. P. ; Van Der Steeg, M. ; Van Der Gen, A. / Synthesis and biological activity of analogs of fecapentaene-12. In: Journal of Natural Products. 1987 ; Vol. 50, No. 1. pp. 75-83.
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