Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33

Elizabeth E. Sugg, Jennifer E. Shook, Mariangela Serra, Murray Korc, Henry I. Yamamura, Thomas F. Burks, Victor J Hruby

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Abstract

Two analogues of [Nle28,31]-CCK26-33 containing an N-terminal acetyl or N-terminal hydroxysulfonyl moiety were prepared and characterized. Both analogues were equipotent to native CCK26-33 in four bioassays, demonstrating that N-terminal sulfation of CCK26-33 analogues is compatible with full biological activity.

Original languageEnglish (US)
Pages (from-to)1623-1629
Number of pages7
JournalLife Sciences
Volume39
Issue number18
DOIs
StatePublished - Nov 3 1986

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Bioassay
Bioactivity
Biological Assay

ASJC Scopus subject areas

  • Pharmacology

Cite this

Sugg, E. E., Shook, J. E., Serra, M., Korc, M., Yamamura, H. I., Burks, T. F., & Hruby, V. J. (1986). Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33. Life Sciences, 39(18), 1623-1629. https://doi.org/10.1016/0024-3205(86)90158-X

Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33. / Sugg, Elizabeth E.; Shook, Jennifer E.; Serra, Mariangela; Korc, Murray; Yamamura, Henry I.; Burks, Thomas F.; Hruby, Victor J.

In: Life Sciences, Vol. 39, No. 18, 03.11.1986, p. 1623-1629.

Research output: Contribution to journalArticle

Sugg, EE, Shook, JE, Serra, M, Korc, M, Yamamura, HI, Burks, TF & Hruby, VJ 1986, 'Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33', Life Sciences, vol. 39, no. 18, pp. 1623-1629. https://doi.org/10.1016/0024-3205(86)90158-X
Sugg EE, Shook JE, Serra M, Korc M, Yamamura HI, Burks TF et al. Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33. Life Sciences. 1986 Nov 3;39(18):1623-1629. https://doi.org/10.1016/0024-3205(86)90158-X
Sugg, Elizabeth E. ; Shook, Jennifer E. ; Serra, Mariangela ; Korc, Murray ; Yamamura, Henry I. ; Burks, Thomas F. ; Hruby, Victor J. / Synthesis and biological evaluation of Nα-hydroxysulfonyl-[Nle28,31]-CCK26-33. In: Life Sciences. 1986 ; Vol. 39, No. 18. pp. 1623-1629.
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