Synthesis and characterization of copolymeric micelles loaded with Taxol® as potential drug delivery systems for cancer treatment

L. V. Tapia, J. S. Castro, C. A. Martinez, P. E. Garcia, C. A. Rodriguez, P. A. Deymier

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Taxol (Paclitaxel) is a very potent anticancer drug used in chemotherapy treatments. Due to its hydrophobic nature, toxic solubilizing agents are used to administer the drug via intravenously. However, this systemic administration is associated with toxic side effects and drug limited efficacy. An alternative to these problems are polymeric micelles. The effectiveness of this drug delivery system is related to its size, modification of pharmacokinetics, drug delivery control and toxicity reduction. In this study, micelles based on methoxy Poly(ethylene glycol)-block-Poly(ε-caprolactone) (mPEG-b-PCL) copolymer loaded with Taxol were synthesized thorough an uncommon method namely powder formulation, using tert-butanol as co-solvent, to our knowledge no reported previously for these micells. Taxol was conjugated to the hydrophobic block of mPEG-b-PCL copolymer. Characterization of this system was done by means of Fourier Transform Infrared Spectroscopy (FT-IR) and Field Emission Scanning Electron Microscopy (FESEM), observing good results as compared to previous reports.

Original languageEnglish (US)
Title of host publicationBiomaterials for Medical Applications
Pages67-72
Number of pages6
DOIs
StatePublished - Dec 1 2011
Event20th International Materials Research Congress, IMRC 2011 - Cancun, Mexico
Duration: Aug 14 2011Aug 19 2011

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1376
ISSN (Print)0272-9172

Other

Other20th International Materials Research Congress, IMRC 2011
CountryMexico
CityCancun
Period8/14/118/19/11

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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    Tapia, L. V., Castro, J. S., Martinez, C. A., Garcia, P. E., Rodriguez, C. A., & Deymier, P. A. (2011). Synthesis and characterization of copolymeric micelles loaded with Taxol® as potential drug delivery systems for cancer treatment. In Biomaterials for Medical Applications (pp. 67-72). (Materials Research Society Symposium Proceedings; Vol. 1376). https://doi.org/10.1557/opl.2012.283