Synthesis and evaluation of cholecystokinin trimers: A multivalent approach to pancreatic cancer detection and treatment

Nabila Brabez, Kevin L. Nguyen, Kara Saunders, Ryan Lacy, Liping Xu, Robert J. Gillies, Ronald M. Lynch, Gerard Chassaing, Solange Lavielle, Victor J. Hruby

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

In the quest for novel tools for early detection and treatment of cancer, we propose the use of multimers targeting overexpressed receptors at the cancer cell surface. Indeed, multimers are prone to create multivalent interactions, more potent and specific than their corresponding monovalent versions, thus enabling the potential for early detection. There is a lack of tools for early detection of pancreatic cancer, one of the deadliest forms of cancer, but CCK2-R overexpression on pancreatic cancer cells makes CCK based multimers potential markers for these cells. In this Letter, we describe the synthesis and evaluation of CCK trimers targeting overexpressed CCK2-R.

Original languageEnglish (US)
Pages (from-to)2422-2425
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number8
DOIs
StatePublished - Apr 15 2013

Keywords

  • CCK
  • Early detection
  • Multimers
  • Multivalent interactions
  • Pancreatic cancer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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