Synthesis and structure-activity relationships of cytotoxic 7-hydroxy sterols

Carl E. Heltzel, A. A.Leslie Gunatilaka, David G.I. Kingston, Glenn A. Hofmann, Randall K. Johnson

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The cytotoxic sterols 1 and 2, previously isolated from Pseudobersama mossambicenis, have been synthesized in nine steps from stigmasterol, together with seven related sterols. Structure-activity relationships of these sterols in cytotoxicity and DNA-damaging assays are discussed.

Original languageEnglish (US)
Pages (from-to)620-628
Number of pages9
JournalJournal Of Natural Products
Volume57
Issue number5
DOIs
StatePublished - May 1 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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