Synthesis of 1,2,3,6-Tetrahydropyridines via Aminophosphate Enabled Anionic Cascade and Acid Catalyzed Cyclization Approaches

Pradipta Das, Jon T Njardarson

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Two new approaches for forming 1,2,3,6-tetrahydropyridines are reported. Both reactions employ a strategic phosphate substituent on the nitrogen atom. In the presence of an additional phosphate substituent (X = P = O(OEt)<inf>2</inf>) an anionic cascade can by triggered upon treatment with base. Alternatively, when X = H the same 1,2,3,6-tetrahydropyridine product can be accessed via an acid catalyzed cyclization.

Original languageEnglish (US)
Pages (from-to)4030-4033
Number of pages4
JournalOrganic Letters
Volume17
Issue number16
DOIs
StatePublished - Aug 13 2015

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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