Synthesis of a cyclic melanotropic peptide exhibiting both melanin-concentrating and -dispersing activities

Brian C. Wilkes, Victor J. Hruby, A. M.De L. Castrucci, Wade C. Sherbrooke, Mac E. Hadley

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

A putative melanin-concentrating hormone was synthesized. This peptide, H-Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-ValOH, stimulates melanin granule aggregation within teleost melanocytes at nanomolar concentrations as does the natural purified teleost pituitary preparation. In addition, this peptide stimulates melanin granule dispersion within melanocytes of frogs and lizards. The peptide has about one six-hundredth of the activity of amelanocyte-stimulating hormone on frog and lizard melanocytes and is a full agonist.

Original languageEnglish (US)
Pages (from-to)1111-1113
Number of pages3
JournalScience
Volume224
Issue number4653
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • General

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