Synthesis of carbohydrate-based antibiotics

Chi Huey Wong, Marian C. Bryan, Paul T. Nyffeler, Haitian Liu, Eli Chapman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Tackling the problem of carbohydrate recognition is a subject of current interest. Our strategies in this regard include development of new methods for the synthesis of saccharides and sugar arrays for screening, design of D-peptides to target bacterial cell-surface sugars, preparation of mechanism-based inhibitors of the enzymes involved in the biosynthesis of saccharides and the synthesis of aminoglycoside mimetics to target RNA.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalPure and Applied Chemistry
Volume75
Issue number2-3
StatePublished - Feb 2003
Externally publishedYes

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Antibiotics
Carbohydrates
Sugars
Anti-Bacterial Agents
Biosynthesis
Aminoglycosides
Enzyme Inhibitors
RNA
Peptides
Screening
Enzymes

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Wong, C. H., Bryan, M. C., Nyffeler, P. T., Liu, H., & Chapman, E. (2003). Synthesis of carbohydrate-based antibiotics. Pure and Applied Chemistry, 75(2-3), 179-186.

Synthesis of carbohydrate-based antibiotics. / Wong, Chi Huey; Bryan, Marian C.; Nyffeler, Paul T.; Liu, Haitian; Chapman, Eli.

In: Pure and Applied Chemistry, Vol. 75, No. 2-3, 02.2003, p. 179-186.

Research output: Contribution to journalArticle

Wong, CH, Bryan, MC, Nyffeler, PT, Liu, H & Chapman, E 2003, 'Synthesis of carbohydrate-based antibiotics', Pure and Applied Chemistry, vol. 75, no. 2-3, pp. 179-186.
Wong CH, Bryan MC, Nyffeler PT, Liu H, Chapman E. Synthesis of carbohydrate-based antibiotics. Pure and Applied Chemistry. 2003 Feb;75(2-3):179-186.
Wong, Chi Huey ; Bryan, Marian C. ; Nyffeler, Paul T. ; Liu, Haitian ; Chapman, Eli. / Synthesis of carbohydrate-based antibiotics. In: Pure and Applied Chemistry. 2003 ; Vol. 75, No. 2-3. pp. 179-186.
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