Synthesis of DNA oligomers possessing a covalently cross-linked Watson - Crick base pair model

Hong Yu Li, Yao Ling Qiu, Elisabeth Moyroud, Yoshito Kishi

Research output: Contribution to journalArticle

31 Scopus citations


Building bridges: A feasible solidphase synthesis of antiparallel n-, h-, and H-type DNA oligomers (see picture) has been demonstrated. The oligomers possess a CH2-bridged base-pair model that should be conformationally flexible, even after base pairing.

Original languageEnglish (US)
Pages (from-to)1471-1475
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number8
StatePublished - Apr 17 2001



  • Nucleosides
  • Nucleotides
  • Oligonucleotides
  • Solid-phase synthesis
  • Watson-Crick base pairs

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this