Synthesis of (E)-5-methoxy-2-styryl-4-pyrones as potent growth-inhibitory agents against hepatocellular carcinoma cells

Yu Hua Chen, Pei Jung Lu, Christopher Hulme, Arthur Y. Shaw

Research output: Contribution to journalArticle

Abstract

The present study a series of (E)-5-methoxy-2-styryl-4H-pyran-4-ones 6a, 6b, 6c, 6d, 6e, 6f, 6g, 6h, 6i, 6j was synthesized and evaluated for growth inhibitory inhibition against carcinoma cells. The growth inhibition study of eight carcinoma cell lines was examined and demonstrated that SKHep cells exhibit significant structure-activity relationship in response to the tested compounds. Among them, 6f showed the most potent activity against SKHep, A549, AGS, and H460 cell lines with GI50 values of 0.17, 8.3, 3.6, 8.0 μM, respectively.

Original languageEnglish (US)
Pages (from-to)56-61
Number of pages6
JournalJournal of Heterocyclic Chemistry
Volume51
Issue number1
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Arbuzov reaction
  • Horner-Emmons reaction
  • carcinoma cells
  • growth-inhibitory agents
  • kojic acid

ASJC Scopus subject areas

  • Organic Chemistry

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