Synthesis of ethyl N-(diphenyl)methyl-1,2,3,4- tetrahydroisoquinoline-3-carboxylates

Eugene A Mash, Lawrence J. Williams, Steven S. Pfeiffer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A concise method for the synthesis of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives from α,α'-dibromo-o-xylenes via sequential C-alkylation and N-alkylation of a glycine anion is described.

Original languageEnglish (US)
Pages (from-to)6977-6980
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number40
DOIs
StatePublished - Oct 6 1997

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Alkylation
Glycine
Anions
Derivatives
diphenyl
1,2,3,4-tetrahydroisoquinoline carboxylic acid
1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
2-xylene

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis of ethyl N-(diphenyl)methyl-1,2,3,4- tetrahydroisoquinoline-3-carboxylates. / Mash, Eugene A; Williams, Lawrence J.; Pfeiffer, Steven S.

In: Tetrahedron Letters, Vol. 38, No. 40, 06.10.1997, p. 6977-6980.

Research output: Contribution to journalArticle

Mash, Eugene A ; Williams, Lawrence J. ; Pfeiffer, Steven S. / Synthesis of ethyl N-(diphenyl)methyl-1,2,3,4- tetrahydroisoquinoline-3-carboxylates. In: Tetrahedron Letters. 1997 ; Vol. 38, No. 40. pp. 6977-6980.
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