Synthesis of highly functionalized chiral 3,3′-disubstituted oxindoles via an organocatalytic enantioselective Michael addition of nitroalkanes to indolylidenecyanoacetates

Lu Liu, Deyan Wu, Shu Zheng, Tengfei Li, Xiangmin Li, Sinan Wang, Jian Li, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

An efficient bifunctional cinchona alkaloid derived thiourea-promoted enantioselective conjugate addition of nitroalkanes to indolylidenecyanoacetates has been developed under neat conditions. The process leads to synthetically interesting densely functionalized 3,3′-disubstituted oxindoles with creation of up to three stereogenic centers.

Original languageEnglish (US)
Pages (from-to)134-137
Number of pages4
JournalOrganic Letters
Volume14
Issue number1
DOIs
StatePublished - Jan 6 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Synthesis of highly functionalized chiral 3,3′-disubstituted oxindoles via an organocatalytic enantioselective Michael addition of nitroalkanes to indolylidenecyanoacetates'. Together they form a unique fingerprint.

Cite this