Synthesis of indoline-piperidinones: Via a novel Ugi, ring expansion, pseudo -Dieckmann condensation and rearrangement cascade reaction

Jie Lei, Gui Ting Song, Ya Fei Luo, Dian Yong Tang, Wei Yan, Hong Yu Li, Zhong Zhu Chen, Zhi Gang Xu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

An Ugi, ring expansion, pseudo-Dieckmann condensation and rearrangement cascade reaction was discovered for the synthesis of indoline-piperidinones in one pot. A series of targeted compounds was prepared by means of a mild reaction and a simple operation procedure, which could be applicable to a broad scope of Ugi starting materials. This cascade reaction generates opportunities for the tailored synthesis of a wide range of indoline-piperidinone scaffolds through tuneable Ugi inputs.

Original languageEnglish (US)
Pages (from-to)737-741
Number of pages5
JournalOrganic Chemistry Frontiers
Volume7
Issue number5
DOIs
StatePublished - Mar 7 2020
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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