Synthesis of Pyridodiindoles with Anticancer Activity by a Three-Component Cascade Condensation

Zhong Zhu Chen, Shi Qiang Li, Ya Jun Zhang, Dian Yong Tang, Jiang Ping Meng, Jie Lei, Hong Yu Li, Zhi Gang Xu

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A novel three-component cascade reaction was discovered and developed to synthesize pyridodiindoles with the assistance of microwave irradiation. A collection of pyridodiindoles was prepared by means of the mild reaction and simple operation procedure, which could be applicable to a broad scope of functional aldehydes. Screening demonstrated that compound 5g exhibited a good potency in HCT116 cell lines, and this work validated the feasibility of this novel reaction for generating promising bioactive compounds.

Original languageEnglish (US)
Pages (from-to)7811-7815
Number of pages5
JournalOrganic Letters
Volume20
Issue number24
DOIs
StatePublished - Dec 21 2018
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Chen, Z. Z., Li, S. Q., Zhang, Y. J., Tang, D. Y., Meng, J. P., Lei, J., Li, H. Y., & Xu, Z. G. (2018). Synthesis of Pyridodiindoles with Anticancer Activity by a Three-Component Cascade Condensation. Organic Letters, 20(24), 7811-7815. https://doi.org/10.1021/acs.orglett.8b03245