Synthesis of [14C]-imexon

Bhumasamudram Jagadish, Bhashyam S. Iyengar, Anikó M. Sólyom, William A. Remers, Robert T Dorr, Jason Shin Yu, Surendra Gupta, Eugene A Mash

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A four-step synthesis of [14C]-imexon is described, starting from [14C]-phosgene. The overall yield is 27% and the specific activity is 55 mCi/mmol.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume48
Issue number3
DOIs
StatePublished - Mar 2005

Fingerprint

Phosgene
4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one

Keywords

  • Anticancer agent
  • Aziridine
  • Imexon
  • Sulfhydryl-binding

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Clinical Biochemistry
  • Molecular Medicine
  • Pharmacology

Cite this

Jagadish, B., Iyengar, B. S., Sólyom, A. M., Remers, W. A., Dorr, R. T., Yu, J. S., ... Mash, E. A. (2005). Synthesis of [14C]-imexon. Journal of Labelled Compounds and Radiopharmaceuticals, 48(3), 165-170. https://doi.org/10.1002/jlcr.911

Synthesis of [14C]-imexon. / Jagadish, Bhumasamudram; Iyengar, Bhashyam S.; Sólyom, Anikó M.; Remers, William A.; Dorr, Robert T; Yu, Jason Shin; Gupta, Surendra; Mash, Eugene A.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 48, No. 3, 03.2005, p. 165-170.

Research output: Contribution to journalArticle

Jagadish, B, Iyengar, BS, Sólyom, AM, Remers, WA, Dorr, RT, Yu, JS, Gupta, S & Mash, EA 2005, 'Synthesis of [14C]-imexon', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 48, no. 3, pp. 165-170. https://doi.org/10.1002/jlcr.911
Jagadish B, Iyengar BS, Sólyom AM, Remers WA, Dorr RT, Yu JS et al. Synthesis of [14C]-imexon. Journal of Labelled Compounds and Radiopharmaceuticals. 2005 Mar;48(3):165-170. https://doi.org/10.1002/jlcr.911
Jagadish, Bhumasamudram ; Iyengar, Bhashyam S. ; Sólyom, Anikó M. ; Remers, William A. ; Dorr, Robert T ; Yu, Jason Shin ; Gupta, Surendra ; Mash, Eugene A. / Synthesis of [14C]-imexon. In: Journal of Labelled Compounds and Radiopharmaceuticals. 2005 ; Vol. 48, No. 3. pp. 165-170.
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