Synthesis of 15N-1 nicotinamide. A general, one step synthesis of 15N labeled pyridine heterocycles

N. J. Oppenheimer, Terry O Matsunaga, B. L. Kam

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13 Scopus citations


A one step, high yield synthesis is reported of 15N-1 nicotinamide from the reaction of 15N ammonia with 1-N-(2,4-dinitrobenzene)-3-carbamoyl-pyridinium chloride. This reaction represents a specific example of a general and facile method for the synthesis of a wide variety of 15N labeled pyridine heterocycles.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
VolumeVOL. 15
Publication statusPublished - 1978
Externally publishedYes


ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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