Synthesis of 15N‐1 nicotinamide. A general, one step synthesis of 15N labeled pyridine heterocycles

Norman J. Oppenheimer, Terry O. Matsunaga, Bernard L. Kam

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A one step, high yield synthesis is reported of 15N‐1 nicotinamide from the reaction of 15N ammonia with 1‐N‐(2,4‐dinitrobenzene)‐3‐carbamoyl‐pyridinium chloride. This reaction represents a specific example of a general and facile method for the synthesis of a wide variety of 15N labeled pyridine heterocycles.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume15
Issue number1 S
DOIs
StatePublished - Oct 1978
Externally publishedYes

Keywords

  • N‐1 Nicotinamide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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