Synthesis of taxol from baccatin III via an oxazoline intermediate

David G.I. Kingston, Ashok G. Chaudhary, A. A.Leslie Gunatilaka, Mark L. Middleton

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Taxol (1) can be prepared in good yield by coupling the oxazoline carboxylic acid 5 with 7-(triethylsilyl)baccatin III, followed by hydrolysis. The oxazolines 7 and 8 can also be prepared directly from taxol.

Original languageEnglish (US)
Pages (from-to)4483-4484
Number of pages2
JournalTetrahedron Letters
Volume35
Issue number26
DOIs
StatePublished - Jun 27 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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