Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids

Francis N. Murigi, Gary S. Nichol, Eugene A Mash

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Abstract

(Chemical Equation Presented) The conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids, were prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L-phenylalanine. Absolute configurations were assigned by X-ray crystallographic analysis.

Original languageEnglish (US)
Pages (from-to)1293-1296
Number of pages4
JournalJournal of Organic Chemistry
Volume75
Issue number4
DOIs
Publication statusPublished - Feb 19 2010

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ASJC Scopus subject areas

  • Organic Chemistry

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